Independent Lineage of Lymphocytic Choriomeningitis Virus in Wood Mice (<i>Apodemus sylvaticus</i>), Spain

Ledesma, Juan; Fedele, Cesare Giovanni; Carro, Francisco; Lledó, Lourdes; Sánchez-Seco, María Paz; Tenorio, Antonio; Soriguer, Ramón C.; Saz, José Vicente; Domínguez, G.; Rosas, María F.; Barandika, Jesús F.; Gegúndez, María Isabel

doi:10.3201/eid1510.090563

Cited by 34 publications

(34 citation statements)

References 14 publications

(16 reference statements)

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“…We have confirmed herein that wood mice from Austria are susceptible to LCMV or closely related arenaviruses, as has already been shown for wood mice from Spain (Ledesma et al 2009). In contrast to previous investigations in Europe (KallioKokko et al 2006), we did not find hints for LCMV infection in yellow-necked field mice, bank voles, and common voles.…”

Section: Discussionsupporting

confidence: 89%

Multiple Infections of Rodents with Zoonotic Pathogens in Austria

Schmidt

Eßbauer

Mayer‐Scholl

et al. 2014

Vector-Borne and Zoonotic Diseases

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Rodents are important reservoirs for a large number of zoonotic pathogens. We examined the occurrence of 11 viral, bacterial, and parasitic agents in rodent populations in Austria, including three different hantaviruses, lymphocytic choriomeningitis virus, orthopox virus, Leptospira spp., Borrelia spp., Rickettsia spp., Bartonella spp., Coxiella burnetii, and Toxoplasma gondii. In 2008, 110 rodents of four species (40 Clethrionomys glareolus, 29 Apodemus flavicollis, 26 Apodemus sylvaticus, and 15 Microtus arvalis) were trapped at two rural sites in Lower Austria. Chest cavity fluid and samples of lung, spleen, kidney, liver, brain, and ear pinna skin were collected. We screened selected tissue samples for hantaviruses, lymphocytic choriomeningitis virus, orthopox viruses, Leptospira, Borrelia, Rickettsia, Bartonella spp., C. burnetii, and T. gondii by RT-PCR/PCR and detected nucleic acids of Tula hantavirus, Leptospira spp., Borrelia afzelii, Rickettsia spp., and different Bartonella species. Serological investigations were performed for hantaviruses, lymphocytic choriomeningitis virus, orthopox viruses, and Rickettsia spp. Here, Dobrava-Belgrade hantavirus-, Tula hantavirus-, lymphocytic choriomeningitis virus-, orthopox virus-, and rickettsia-specific antibodies were demonstrated. Puumala hantavirus, C. burnetii, and T. gondii were neither detected by RT-PCR/PCR nor by serological methods. In addition, multiple infections with up to three pathogens were shown in nine animals of three rodent species from different trapping sites. In conclusion, these results show that rodents in Austria may host multiple zoonotic pathogens. Our observation raises important questions regarding the interactions of different pathogens in the host, the countermeasures of the host's immune system, the impact of the host-pathogen interaction on the fitness of the host, and the spread of infectious agents among wild rodents and from those to other animals or humans.

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Section: Discussionsupporting

confidence: 89%

Multiple Infections of Rodents with Zoonotic Pathogens in Austria

Schmidt

Eßbauer

Mayer‐Scholl

et al. 2014

Vector-Borne and Zoonotic Diseases

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“…1) in fall 2008 were seropositive. Our results are in line with the earlier findings of LCMV-like antibodies in a number of rodent species in Europe without sympatric Mus species , Tagliapietra et al 2009, and thus support the circulation of multiple LCMV-like strains (see Ledesma et al 2009). …”

Section: Discussionsupporting

confidence: 82%

“…However, high seroprevalence in other mice and vole species (including field voles) , Blasdell et al 2008, Tagliapietra et al 2009), and the identification of an independent genetic lineage in wood mice (Ledesma et al 2009), has led to the suggestion of spillover and/or the circulation of multiple related and cross-reactive arenaviruses.…”

Section: Introductionmentioning

confidence: 99%

Food resources and intestinal parasites as limiting factors for boreal vole populations during winter

Forbes

Stuart

Mappes

et al. 2014

Ecology

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Processes limiting the growth of cyclic vole populations have stimulated considerable research and debate over several decades. In Fennoscandia, the peak density of cyclic vole populations occurs in fall, and is followed by a severe winter decline. Food availability and intestinal parasites have been demonstrated to independently and synergistically limit wildlife populations. The purpose of this study was to directly compare competing food and parasite hypotheses on the limitation of overwintering high‐density vole populations. Moreover, we evaluated the ability of food limitation and nematode infection to interact and thereby intensify population declines. A two‐factor experiment with food supplementation and antihelminthic medication was conducted on replicated, enclosed field vole (Microtus agrestis) populations in central Finland over one full boreal winter. Population abundance, survival, and demographic attributes were monitored through live trapping. Vole feces were concurrently examined for the eggs of Heligmosomidae nemadotes and oocysts of eimerian coccidians. We found that vole density declined in all treatment groups throughout winter. However, food supplementation mitigated this decline through positive effects on reproduction, and voles in food‐supplemented populations were generally in better physiological condition than non‐supplemented voles. Food supplementation and antihelminthic treatment reduced the prevalence of Heligmosomidae nematodes, while neither food nor medication affected the prevalence of eimerians, or infection intensity of either parasite group. Although food supplementation and antihelminthic medication aided in the clearance of Heligmosomidae nematodes, their prevalence did not influence vole population growth, and this parasite group is therefore unlikely to contribute to the cyclic winter decline of boreal vole populations. Instead food resources acting alone were the primary factor limiting vole population growth.

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“…The L segment encodes the viral RNA-dependent RNA polymerase (L) and the small zinc finger-like protein (Z). The main natural reservoir of LCMV is the common house mouse, Mus musculus, but other rodent species can be alternative reservoirs (3,4). LCMV has been shown to circulate among both its natural host and humans on the European, Asian, and American continents.…”

mentioning

confidence: 99%

Evidence of Lymphocytic Choriomeningitis Virus (LCMV) in Domestic Mice in Gabon: Risk of Emergence of LCMV Encephalitis in Central Africa

N’Dilimabaka

Berthet

Rougeron

et al. 2015

J Virol

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e Lymphocytic choriomeningitis virus (LCMV) can cause acute fatal disease on all continents but was never detected in Africa. We report the first detection of LCMV RNA in a common European house mouse (Mus musculus domesticus) in Africa. Phylogenetic analyses show a close relationship with North American strains. These findings suggest that there is a risk of the appearance of LCMV acute encephalitis cases. This is a perfect example of virus dissemination by its natural host that may have dramatic public health consequences.

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Independent Lineage of Lymphocytic Choriomeningitis Virus in Wood Mice (Apodemus sylvaticus), Spain

Cited by 34 publications

References 14 publications

Multiple Infections of Rodents with Zoonotic Pathogens in Austria

Multiple Infections of Rodents with Zoonotic Pathogens in Austria

Food resources and intestinal parasites as limiting factors for boreal vole populations during winter

Evidence of Lymphocytic Choriomeningitis Virus (LCMV) in Domestic Mice in Gabon: Risk of Emergence of LCMV Encephalitis in Central Africa

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