Independent influences of body mass and gastric volumes on satiation in humans

Delgado-Aros, Sílvia; Cremonini, Filippo; Castillo, Janet E.; Chial, Heather J.; Burton, Duane D.; Ferber, Irene; Camilleri, Michael

doi:10.1053/j.gastro.2003.11.007

Cited by 141 publications

(117 citation statements)

References 51 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Each of these attributes has been associated with weaker effects on appetite and dietary compensation. [52][53][54][55][56][57][58][59] The absolute and relative importance of these properties, and others, has not been established, but warrant exploration. In summary, the present trial supports an independent effect of food rheology on energy intake.…”

Section: Discussionmentioning

confidence: 99%

Effects of food form on appetite and energy intake in lean and obese young adults

et al. 2007

View full text Add to dashboard Cite

Objective: To investigate the independent effect of food form on appetite and energy intake in lean and obese adults using high carbohydrate, fat or protein food stimuli. Design: Crossover dietary challenge with matched beverage and solid food forms: high carbohydrate (watermelon and watermelon juice); high protein (cheese and milk); high fat (coconut meat and coconut milk). Results: Regardless of the predominant energy source, the beverage food form elicited a weaker compensatory dietary response than the matched solid food form. Thus, total daily energy intake was significantly higher by 12.4, 19 and 15% on days the beverage forms of the high-carbohydrate, -fat and -protein foods were ingested, respectively. This was due more to a weak effect on satiety than satiation. The obese participants had higher energy intake at the lunch, including the beverage highprotein load, but overall differences between lean and obese participants were small and not systematic. Conclusion: Food rheology exerts an independent effect on energy intake. Dietary compensation for beverages is weaker than for solid food forms of comparable nutrient content. Thus, they pose a greater risk for promoting positive energy balance.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of food form on appetite and energy intake in lean and obese young adults

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Subsequent open-label human studies and three small randomized trials have reported conflicting results, with some studies finding little or no body weight loss after gastric BTA injection [5][6][7][8][9][10], and one randomized controlled trial showing statistically significant decreases in gastric emptying and body weight [11]. These trials differed in BTA dose (100 to 300 U in Botox formulation equivalents) and location of injections (antrum alone vs. antrum, body, and cardia).…”

Section: Introductionmentioning

confidence: 99%

Endoscopic Ultrasound-Guided Gastric Botulinum Toxin Injections in Obese Subjects: A Pilot Study

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…Insulin was measured by a two-site immunoenzymatic assay performed on an Access automated immunoassay system (Beckman Instruments, Chaska, MN, USA). 8 Insulin intra-assay coefficients of variation are 2% at 6.75 uU ml À1 and 2.6% at 116 uU ml À1 . Insulin interassay coefficients of variation are 3.9% at 12.7 uU ml À1 , 3.9% at 48.8 uU ml À1 and 4.6% at 121 uU ml À1 .…”

Section: Study Design and Protocolmentioning

confidence: 95%

“…8 Glucose was measured using a glucose oxidase method (Yellow Springs Instrument, Yellow Springs, OH, USA). Insulin was measured by a two-site immunoenzymatic assay performed on an Access automated immunoassay system (Beckman Instruments, Chaska, MN, USA).…”

Section: Study Design and Protocolmentioning

confidence: 99%

“…Gender, age and body mass index were included in the analysis as potential confounding variables on the basis of previous reports. 8 To evaluate the effect of DGE at 15 and 60 min after initiation of meal ingestion on caloric intake and postprandial symptoms, respectively, we used multiple (linear) regression modeling. GE parameters were entered in the models as the principal independent variables, and gender, age, BMI and baseline variables were explored as covariates.…”

Section: Eating Attitude Test (Eat-26)mentioning

confidence: 99%

See 1 more Smart Citation

Meal size can be decreased in obese subjects through pharmacological acceleration of gastric emptying (The OBERYTH trial)

Torra

Ilzarbe

Malagelada³

et al. 2010

Int J Obes

View full text Add to dashboard Cite

Background: Entry of nutrients into the small intestine activates neuro-hormonal signals that regulate food intake through induction of satiation. Objective: To evaluate whether caloric intake can be decreased by pharmacologically accelerating gastric emptying (GE) of nutrients into the small intestine. Methods: Subjects were tested in 2 days, at baseline (day1) and after randomly receiving, in a double-blind manner, a 1 h infusion of erythromycin (3 mg Kg À1 , to accelerate GE) or placebo (day 2). Ad libitum caloric intake and postprandial gastrointestinal symptoms were evaluated using a validated nutrient drink test, simultaneously measuring gastric by scintigraphy. Plasma levels of satiation factors were also measured to evaluate their role in the modification of caloric intake and postprandial symptoms. Acceleration of GE was assessed as the difference in percentage emptied between day 2 and day 1 (DGE). The effects of DGE on caloric intake and symptoms were evaluated using multiple (lineal) regression. Results: Among 30 overweight/obese subjects (24F and 6 M), 15 received erythromycin and 15 placebo. The overall median age was 36 years (IQR: 30-42) and body mass index was 30 Kg m À2 (IQR: 27-36). Subjects receiving erythromycin on day 2 presented accelerated GE as compared with placebo (P ¼ 0.0002). DGE at 15 min after initiating eating had a significant effect on prospective caloric intake (P ¼ 0.004). From the best-fitted regression model (R 2 ¼ 81%, Po0.0001), a 10% increase in GE at 15 min induced on an average a 135±43.5 Kcal decrease in caloric intake. Postprandial increase in cholecystokinin (CCK) (P ¼ 0.03) and insulin (P ¼ 0.02) was associated with decreased caloric intake. Acceleration of GE at 60 min after initiating eating increased postprandial symptom scores measured 30 min after the completion of food consumption (P ¼ 0.01). Postprandial increase in CCK (P ¼ 0.002) and PP (P ¼ 0.02) was associated with postprandial symptoms. Conclusion: Meal size can be reduced in overweight/obese subjects by pharmacologically accelerating GE. This may be a reasonable target in obesity management.

show abstract

Independent influences of body mass and gastric volumes on satiation in humans

Cited by 141 publications

References 51 publications

Effects of food form on appetite and energy intake in lean and obese young adults

Effects of food form on appetite and energy intake in lean and obese young adults

Endoscopic Ultrasound-Guided Gastric Botulinum Toxin Injections in Obese Subjects: A Pilot Study

Meal size can be decreased in obese subjects through pharmacological acceleration of gastric emptying (The OBERYTH trial)

Contact Info

Product

Resources

About