Independent effects of blood pressure and parathyroid hormone on aortic pulse wave velocity in untreated Chinese patients

Abstract

Arterial stiffness, as assessed by PWV, independently increased both with BP and with PTH, but BP remains the main driver of arterial stiffening.

Serum levels of sclerostin as a potential biomarker in central arterial stiffness among hypertensive patients

“…One systematic review found that in approximately 90% of the studies, age and BP were consistently independently associated with cfPWV values, whereas DM was associated with cfPWV values in 52% of the studies [ 25 ]. A study found that BP was positively associated with the cfPWV values and was regarded as the main driver of arterial stiffening in 1052 untreated patients [ 26 ]. Similarly, we found that hypertensive patients with high arterial stiffness were older, presented with higher SBPs, and had a higher incidence of DM.…”

“…PTH was associated with an increased risk of nonfatal atherosclerotic disease in two prospective, community-based studies focusing on elderly patients [ 35 ]. Moreover, a recent study found that PTH had both a direct and a BP-mediated indirect effect on the cfPWV values [ 26 ]. In our study, elevated iPTH levels revealed a significant association with high arterial stiffness and iPTH levels was also positively associated with cfPWV values in patients with hypertension.…”

Association of pulse wave velocity with single nucleotide polymorphisms related to parathyroid hormone

“…In pathway analysis, the association of PWV with PTH did not run via serum or urinary calcium, but had both a direct hormone-dependent and blood-pressure mediated component. There was no association between cfPWV and serum 25-hydroxy-vitamin D [1].…”

“…The current study builds on our own observations [1] and the GWAS study [2]. We investigated whether in untreated Chinese patients, arterial stiffness, as exemplified by pulse wave velocity (PWV) in elastic and muscular segments of the arterial tree, was associated with rs6127099 or rs4074995 and might contribute to the blood pressure independent association between cfPWV and PTH as reported previously [1].…”

“…We recently demonstrated in 1052 untreated Chinese patients referred for ambulatory blood pressure monitoring that carotid-femoral pulse wave velocity (cfPWV) was independently associated with both blood pressure and the serum level of parathyroid hormone (PTH) [1]. Per 1-SD increment in the systolic or diastolic 24 h blood pressure, cfPWV was 0.40 m/s or 0.23 m/s faster.…”