Independent Determinants of Second Derivative of the Finger Photoplethysmogram among Various Cardiovascular Risk Factors in Middle-Aged Men

Otsuka, Toshiaki; Kawada, Tomoyuki; Katsumata, Masao; Ibuki, Chikao; Kusama, Yoshiki

doi:10.1291/hypres.30.1211

Cited by 29 publications

(32 citation statements)

References 41 publications

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“…Age and hypertension are common factors affecting the c/a and HRV indices of HF. The current results showing relationships between age and SDPTG indices are consistent with the findings of previous studies 4,15) . In the present study, the b/a increased pendent determinants of the c/a.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, the importance of the cardiac parasympathetic activity has been emphasized due to its ability to antagonize arrhythmogenic sympathetic hyperactivity, which leads to sudden cardiac death after myocardial infarction 23) . We also found that the DBP was an independent determinant of the d/a, in accordance with previous findings showing that the d/a reflects peripheral vascular resistance 2,15) . In a previous study 24) , we evaluated SDPTG indices (b/a, d/a and the aging index [AGI]) in response to tracheal intubation in patients ≥ 40 years of age in the with age, while the d/a decreased with age, suggesting that stiffness of large arteries increases, while peripheral vascular resistance or the left ventricular afterload increases with age.…”

Section: Discussionsupporting

confidence: 92%

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Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

Kohjitani

Miyata

Iwase

et al. 2014

JAT

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A multivariate regression analysis showed that the LF, HF and heart rate were independent determinants of the c/a. Furthermore, the c/a values were significantly lower in the patients with hypertension, diabetes mellitus and hyperlipidemia than in those without these diseases, and a reduced c/a was significantly associated with increased serum triglyceride and total cholesterol concentrations. Conclusions: These findings suggest that a decrease in c/a is associated with a reduced baroreflex response of the peripheral vasomotor activity and a decreased cardiac parasympathetic activity. Furthermore, a decrease in c/a was found to be associated with atherosclerosis-based conditions, such as hypertension, diabetes mellitus and hyperlipidemia. J Atheroscler Thromb, 2014; 21:501-508.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

Kohjitani

Miyata

Iwase

et al. 2014

JAT

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“…The details of this procedure are described elsewhere [8]. Namely, the SDPTG consists of 4 waves in systole ("a," "b," "c," and "d" waves) and 1 wave in diastole ("e" wave).…”

Section: Methodsmentioning

confidence: 99%

Factor Structure of Indices of the Second Derivative of the Finger Photoplethysmogram with Metabolic Components and Other Cardiovascular Risk Indicators

Kawada

Otsuka

2013

Diabetes Metab J

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BackgroundThe second derivative of the finger photoplethysmogram (SDPTG) is an indicator of arterial stiffness. The present study was conducted to clarify the factor structure of indices of the SDPTG in combination with components of the metabolic syndrome (MetS), to elucidate the significance of the SDPTG among various cardiovascular risk factors.MethodsThe SDPTG was determined in the second forefinger of the left hand in 1,055 male workers (mean age, 44.2±6.4 years). Among 4 waves of SDPTG components, the ratios of the height of the "a" wave to that of the "b" and "d" waves were expressed as b/a and d/a, and used as SDPTG indices for the analysis.ResultsPrincipal axis factoring analysis was conducted using age, SDPTG indices, components of MetS, and the serum levels of C-reactive protein (CRP) and uric acid. Three factors were extracted, and the SDPTG indices were categorized in combination with age as the third factor. Metabolic components and the SDPTG indices were independently categorized. These three factors explained 44.4% of the total variation. Multiple logistic regression analysis revealed age, d/a, serum uric acid, serum CRP, and regular exercise as independent determinants of the risk of MetS. The odds ratios (95% confidence intervals) were 1.08 (1.04 to 1.11), 0.10 (0.01 to 0.73), 1.24 (1.06 to 1.44), 3.59 (2.37 to 5.42), and 0.48 (0.28 to 0.82), respectively.ConclusionThe SDPTG indices were categorized in combination with age, and they differed in characteristics from components of MetS or inflammatory markers. In addition, this cross-sectional study also revealed decrease of the d/a as a risk factor for the development of MetS.

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“…It is noninvasive and easy for patients to undergo, and we consider that SDPTG is a good parameter of arterial stiffness. Some SDPTG quantifiers were found to be closely correlated with ascending aortic augmentation index, age, and other atherosclerotic risk factors 14–17. The SSE-supplemented group showed significant reduction in vascular age, as estimated by SDPTG-AI at four weeks, and showed a lower vascular age than that of the placebo group at 12 weeks.…”

Section: Discussionmentioning

confidence: 96%

“…Noninvasive pulse wave analysis methods, such as pulse wave velocity, augmentation index, and second derivative of the fingertip photoplethysmogram (SDPTG) have been developed to measure arterial stiffness. These methods have been postulated to predict cardiovascular events 10–17. Several clinical studies have reported the use of drugs for the treatment of arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

Effects of safflower seed extract on arterial stiffness

Suzuki¹,

Tsubaki²,

Fujita³

et al. 2010

VHRM

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Safflower seed extract (SSE) contains characteristic polyphenols and serotonin derivatives (N-( p-coumaroyl) serotonin and N-feruloylserotonin), which are reported to inhibit oxidation of low-density lipoprotein (LDL), formation of atherosclerotic plaques, and improve arterial stiffness as assessed by pulse wave analysis in animal models. The effects of long-term supplementation with SSE on arterial stiffness in human subjects were evaluated. This doubleblind, placebo-controlled study was conducted in 77 males (35–65 years) and 15 postmenopausal females (55–65 years) with high-normal blood pressure or mild hypertension who were not undergoing treatment. Subjects received SSE (70 mg/day as serotonin derivatives) or placebo for 12 weeks, and pulse wave measurements, ie, second derivative of photoplethysmogram (SDPTG), augmentation index, and brachial-ankle pulse wave velocity (baPWV) were conducted at baseline, and at weeks 4, 8, and 12. Vascular age estimated by SDPTG aging index improved in the SSE-supplemented group when compared with the placebo group at four (P = 0.0368) and 12 weeks (P = 0.0927). The trend of augmentation index reduction (P = 0.072 versus baseline) was observed in the SSE-supplemented group, but reduction of baPWV by SSE supplementation was not observed. The SSE-supplemented group also showed a trend towards a lower malondialdehyde-modified-LDL autoantibody titer at 12 weeks from baseline. These results suggest long-term ingestion of SSE in humans could help to improve arterial stiffness.

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Independent Determinants of Second Derivative of the Finger Photoplethysmogram among Various Cardiovascular Risk Factors in Middle-Aged Men

Cited by 29 publications

References 41 publications

Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

Associations between the Autonomic Nervous System and the Second Derivative of the Finger Photoplethysmogram Indices

Factor Structure of Indices of the Second Derivative of the Finger Photoplethysmogram with Metabolic Components and Other Cardiovascular Risk Indicators

Effects of safflower seed extract on arterial stiffness

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