Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations

Abstract

ObjectiveRheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations.MethodsAssociation analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls.ResultsIn unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16–1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19–1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65–0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected.ConclusionThe independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.

HLA-DPB1 rs9277535 polymorphism is associated with rheumatoid arthritis risk in a Chinese Han population

“…Moreover, Furukawa et al . identified an association between DPB102:01 and ACPA (+) RA in Japanese populations [ 17 ]. In addition, O'Brien et al reported that the A allele at rs9277535 was associated with decreased HLA-DPB1 mRNA levels in the normal human liver [ 18 ].…”

Frequency distribution of HLA class I and II alleles in Greek population and their significance in orchestrating the National Donor Registry Program

“…Therefore, the precise determination of an individual's HLA class I and II gene polymorphisms with the use of the NGS approach is considered more efficient compared to the previously used HLA typing methods (Hosomichi et al, 2015;Sanchez-Mazas and Meyer, 2014). As a consequence, this information could be used for better donor-recipient matching, thus reducing the percentage of transplantation failure (Hosomichi et al, 2015) and in disease association studies (Akassou & Bakri, 2018;Augusto & Hollenbach, 2022;Aureli et al, 2015;Fakhkhari et al, 2023;Furukawa et al, 2018;Gough & Simmonds, 2007;McCanlies et al, 2003;Mounzer et al, 2019;Takeno, 2022). This, in turn, may benefit the increase of the available transplant number, worldwide, which can further assist in shortening the recipients' waiting lists (Mangum & Caywood, 2022;Sheldon & Poulton, 2006).…”