HLA-DPB1 rs9277535 polymorphism is associated with rheumatoid arthritis risk in a Chinese Han population

Yang, Zhicheng; Liu, Weixi; Yan, Ting; Liu, Ruiping

doi:10.18632/aging.202864

Cited by 3 publications

(1 citation statement)

References 23 publications

(24 reference statements)

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“…Rheumatoid arthritis (RA) is a common autoimmune disease, which is characterized by chronic synovitis and mainly damages synovial joints [ 1 , 2 ]. According to statistics, its incidence in China ranges between 0.2% and 0.4%.…”

Section: Introductionmentioning

confidence: 99%

Changes of DCE‐MRI Parameters in Patients with Rheumatoid Arthritis before and after Therapy and Their Value for the Efficacy Evaluation of Patients

Chen

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the changes of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters in patients with rheumatoid arthritis (RA) before and after therapy and their value for the efficacy evaluation of patients. Methods. Totally, 90 patients with RA confirmed in our hospital between January 2018 and January 2020 were enrolled. All of them were examined with a Siemens Magnetom Avanto 1.5T imaging system, and data about the rate of enhancement in early stage (REE) and steep slope maximum (SSmax) were obtained. Then, the disease activity score in 28 joints (DAS-28), REE, and SSmax were analyzed, and the associations of SSmax and REE with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and DAS-28 were investigated. Additionally, the patients were assigned to the acute-stage group and the chronic-stage group according to their time-signal intensity curves after therapy, and the two groups were compared in SSmax, REE, ESR, CRP, and DAS-28. Corresponding receiver operating characteristic (ROC) curves were drawn for the analysis of potential markers for efficacy improvement in patients. Results. After therapy, REE, SSmax, ESR, DAS-28, and CRP in the synovium of all patients declined greatly (all P < 0.05 ), with higher levels observed in the acute-stage group than those in the chronic-stage group (all P < 0.05 ). SSmax and REE of patients were positively bound up with their ESR, CRP, and DAS-28 (all P < 0.05 ). Additionally, according to ROC curve-based analysis, both SSmax and REE can be adopted as biological indexes for distinguishing between patients at the acute phase from those at the chronic stage, and joint detection of them can boost the sensitivity of DAS-28. Conclusion. The SSmax and REE levels in RA patients after treatment were significantly decreased, and the levels in patients in the chronic phase were lower than those in patients in the acute phase. SSmax and REE are highly expressed in RA patients, and the combined detection can enhance the value of DAS-28 in the assessment of RA, and it is worthy of clinical promotion.

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Section: Introductionmentioning

confidence: 99%

Changes of DCE‐MRI Parameters in Patients with Rheumatoid Arthritis before and after Therapy and Their Value for the Efficacy Evaluation of Patients

Chen

2021

Evidence-Based Complementary and Alternative Medicine

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Study of some genetic and molecular markers for some rheumatoid arthritis patients in Iraq.

Talib Al-Safi,

T. Qasim

2023

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Rheumatoid arthritis is an autoimmune disorder, and genetic factors strongly contribute to a genetic predisposition to developing the disease. This study evaluated the genetic and molecular indicators of some Iraqi patients with rheumatoid arthritis. The study included (100) patients with rheumatoid arthritis with (100) healthy individuals who attended Al-Hussain General Teaching Hospital, Department of Arthritis and Joints Centre, al Blood Bank in Baghdad for the period from the beginning of January 2022 until the end of March 2022. The patients were diagnosed under the supervision of medical committees specialized in joint diseases. The human leukocyte antigen is one of the essential genetic factors in regulating the immune response, as these antigens contribute to the susceptibility to disease. Human leukocyte antigen (HLA) class II (Class-II- HLA-DR, -DQ) was genotyped using lymphocytotoxicity assay and PCR-SSP method. The results showed that there was a significant increase in the recurrence of human leukocyte antigens (DR4 R53) in rheumatoid arthritis patients compared to the healthy ones, as well as an increase in the recurrence of human leukocyte antigens (HLA-DQ3) with a significant difference in rheumatoid arthritis patients compared to the healthy ones. Regarding HLA-DRB1 and -DQB1 alleles, it was found that there was a significant increase in the frequency of HLA-DRB1*04 (01-22, not 0415) compared to healthy controls, while the percentage of HLA-DRB1*0701 alleles was less frequent in patients compared to healthy controls. Moreover, the frequency of HLADQB1*03(02,07) alleles was high in the patients compared to the healthy ones, while HLA-DQB1*0303 showed a highly significant difference in the healthy group compared to the patients. Keywords: Rheumatoid arthritis, genetic factors, HLA-DRB1, -DQB1 alleles, PCR.

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Treatment of shallow and deep white spot lesions with three different mouthwashes evaluated by laser fluorescence (an in vitro study)

Ali Abdul Hadi,

Faisal Alhuwaiz

2023

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This research aims to find how three different types of mouthwashes affect the depth of artificial white spot lesions. Teeth with various depths of white spot lesions were immersed in either splat mouthwash, Biorepair mouthwash, Sensodyne mouthwash, or artificial saliva (control)twice daily for one minute for 4 weeks and 8 weeks at 37°C. After this immersion procedure, lesion depth was measured using a diagnosed pen score. A one-way analysis of variance, Dunnett T3 and Tukey's post hoc α = .05 were used to analyze the testing data. Splat mouthwash enhanced the WSL remineralization and made the lowest ΔF compared with other mouthwashes in shallow and deep enamel after 4 and 8 weeks of treatment. In the repair groups, after 4 weeks of treatment, significant recovery was observed in shallow enamel. Further improvement in shallow WSL after 8 weeks of treatment with biorepair mouthwash was observed compared to Sensodyne and the control group. Splat mouthwash is more effective than other mouthwashes in remineralizing two depths of WSLs at different time points. Keywords: DIAGNOdent pen, Shallow enamel, Deep enamel, white spot lesion.

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HLA-DPB1 rs9277535 polymorphism is associated with rheumatoid arthritis risk in a Chinese Han population

Cited by 3 publications

References 23 publications

Changes of DCE‐MRI Parameters in Patients with Rheumatoid Arthritis before and after Therapy and Their Value for the Efficacy Evaluation of Patients

Changes of DCE‐MRI Parameters in Patients with Rheumatoid Arthritis before and after Therapy and Their Value for the Efficacy Evaluation of Patients

Study of some genetic and molecular markers for some rheumatoid arthritis patients in Iraq.

Treatment of shallow and deep white spot lesions with three different mouthwashes evaluated by laser fluorescence (an in vitro study)

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