Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

Feng, Feiling; Liu, X X; Sun, Yunbo; Zhang, P; Sun, Shiqun; Zhang, B; Wang, Xiaotian; Lu, Lijun

doi:10.4238/2014.september.26.14

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Previous studies have reported that cytokine genes contribute to susceptibility of TB, such as interferon-1β, interleukin (IL)-3, IL-6, IL-10, and IL-12B IL-17 as well as IL-18 (Selvaraj et al, 2008;Abhimanyu et al, 2011;Meenakshi et al, 2013;Feng et al, 2014;Tiwari et al, 2014;Zhang et al, 2014). However, the results have been inconsistent.…”

Section: Introducioncontrasting

confidence: 40%

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Shi¹,

Zhang²

2015

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism. The genotype distributions of IL-17 rs2275913 were found to be in Hardy-Weinberg equilibrium in the controls, while the IL-17 rs3748067 and rs763780 were not. Based on unconditional logistic regression, individuals carrying the AA genotype and GA + AA genotype of rs2275913 were more likely to have a significantly increased risk of TB compared to subjects with the GG genotype. The ORs (95%CI) for the AA genotype and GA + AA genotype were 2.20 (1.35-3.60) and 1.52 (1.11-2.09), respectively. The CC genotype and TC + CC genotype of rs763780 were associated with increased risk of TB when compared with the TT genotype. The ORs (95%CI) for the CC genotype and TC + CC genotype were 1.99 (1.05-3.87) and 1.58 (1.07-2.33), respectively. In conclusion, rs763780 may play a critical role in the etiology of TB.

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Section: Introducioncontrasting

confidence: 40%

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Shi¹,

Zhang²

2015

Genet. Mol. Res.

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“…Among the included publications, eight evaluated the association between the IL-6 (−174G/C) polymorphism and tuberculosis risk, with 959 cases and 1608 controls; 7 , 18 , 25 – 30 three focused on IL-6 (−572C/G) polymorphism, including 686 cases and 725 controls. 17 , 32 , 33 One article assessed both IL-6 (−174G/C) and (−572C/G) with 495 cases and 358 cases, 18 and it was treated as two independent studies in the present meta-analysis. Consequently, 13 studies were available for analyzing the association between IL-6 gene polymorphism and tuberculosis risk, nine (8 publications) of them were conducted in Asians, 17 , 18 , 25 , 27 , 29 , 30 , 32 , 33 while two were in Caucasians, 26 , 28 and two were in Latinos.…”

Section: Resultsmentioning

confidence: 99%

“…17 , 32 , 33 One article assessed both IL-6 (−174G/C) and (−572C/G) with 495 cases and 358 cases, 18 and it was treated as two independent studies in the present meta-analysis. Consequently, 13 studies were available for analyzing the association between IL-6 gene polymorphism and tuberculosis risk, nine (8 publications) of them were conducted in Asians, 17 , 18 , 25 , 27 , 29 , 30 , 32 , 33 while two were in Caucasians, 26 , 28 and two were in Latinos. 7 , 31 Ten studies (9 publications) recruited pulmonary tuberculosis patient, 17 , 18 , 25 , 27 – 32 three investigated other types of tuberculosis such as tuberculous pleurisy, renal tuberculosis, tuberculous lymphadenitis, and central nervous system tuberculosis.…”

Section: Resultsmentioning

confidence: 99%

Association between the <em>IL-6</em> gene polymorphism and tuberculosis risk: a meta-analysis

Wang

Pang

Zeng

et al. 2017

IDR

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BackgroundThe gene polymorphism of interleukin-6 (IL-6) has been shown to be implicated in tuberculosis susceptibility in many studies, but with conflicting results. This study aimed to provide more accurate estimation of the relationship between IL-6 gene polymorphism and tuberculosis risk through a meta-analysisMethodA literature search was performed in PubMed, EMBASE, and other databases. Data were retrieved, and pooled odds ratio (OR) with 95% CI were calculated. Statistical analyses were performed by using STATA 12.0.ResultsTwelve publications with 2635 cases and 3049 controls were included. The pooled analysis demonstrated significant evidence of association between IL-6 (−174G/C) and low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.693, 95% CI 0.581–0.826, p<0.001). Subgroup analysis got similar results for IL-6 (−174G/C) in Asians and Latinos, but the significance did not exist in Caucasians. IL-6 (−572C/G) polymorphism was also associated with low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.719, 95% CI 0.577–0.896, p=0.003). No publication bias was detected in either of the polymorphisms.ConclusionIn summary, IL-6 −572 C/G polymorphism may be associated with a decreased risk of tuberculosis, and C allele is the protective factor against tuberculosis for IL-6 −174G/C among Asians and Latinos, but not in Caucasian population.

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“…In addition, expression of miR-31 expression was negatively correlated with serum levels of the innate immunity cytokines IL-6, TNF-α, NF-κB, and IFN-γ. IL-6 is secreted by Toll-like receptor 2-expressing cells during early MtB infection, and is involved in anti-tuberculosis immunity (Feng et al, 2014). TNF-α increases the capacity of macrophages to phagocytose and stimulates macrophages apoptosis, which leads to increased presentation of mycobacterial antigens by dendritic cells (Cavalcanti et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients

Jx¹,

Xu²,

Han³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the diagnostic values of microRNA-31 in peripheral blood mononuclear cells (PBMCs) for pediatric pulmonary tuberculosis in Chinese patients. Sixty-five children with TB were selected for this study, which was conducted at the Department of Infectious Diseases People's Hospital of Laiwu City between December 2013 and December 2014. Sixty healthy children, selected in parallel, served as the control group. Real-time PCR was used to detect miR-31 expression in PBMCs. Serum levels of IL-6, TNF-α, NF-κB, and IFN-γ was detected by ELISA. ROC curve was employed to evaluate the diagnostic value of miR-31 in pediatric TB. Results show that expression of miRNA-31 in pediatric TB patients was significantly lower than that in normal children (0.48 ± 0.15 vs 1.23 ± 0.36, P < 0.05). By contrast, serum levels of the innate immune response cytokines, IL-6, TNF-α, NF-κB, and IFN-γ, were significantly higher in pediatric TB patients compared with normal children (P < 0.05). Furthermore, miRNA-31 expression was negatively correlated with serum levels of IL-6 (t = 69.91, P < 0.001), TNF-α (t = 10.96, P < 0.001), NF-κB (t = 39.94, P < 0.001), and IFN -γ (t = 37.94, P < 0.001). The cut-off threshold of miR-31 for pediatric TB diagnosis is 0.835 with a sensitivity of 98.5% and a (2015) specificity of 86.7%. Therefore, miR-31 has the potential to be a diagnostic marker in pediatric TB patients.

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Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

Cited by 7 publications

References 17 publications

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Association between the <em>IL-6</em> gene polymorphism and tuberculosis risk: a meta-analysis

Diagnostic values of microRNA-31 in peripheral blood mononuclear cells for pediatric pulmonary tuberculosis in Chinese patients

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