Association between the &lt;em&gt;IL-6&lt;/em&gt; gene polymorphism and tuberculosis risk: a meta-analysis

Wang, Hao; Pang, Caishuang; Zeng, Ni; Wan, Chun; Shen, Yongchun; Wen, Fuqiang

doi:10.2147/idr.s144296

Cited by 10 publications

(12 citation statements)

References 36 publications

(55 reference statements)

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“…More studies should be performed to investigate the mechanism of how IL-6 polymorphism regulates IL-6 production and plays a role in tuberculosis susceptibility. 6 The current study has not supported a role for IL-6 gene polymorphism in patient susceptibility to MDR pulmonary tuberculosis, since contrasting both genetic allelic variation in MDR TB group against both control and drug-sensitive TB patients has failed to show statistical significance. In accordance with these findings, Milano found no significant association between susceptibility to MDR TB and genotype or allelic polymorphism associating IL-6 (-572G/C) gene locus.…”

Section: Discussioncontrasting

confidence: 67%

“…Therefore, GG genotype may be associated with less risk of pulmonary TB in comparison with GC and CC genotypes. In accordance with these findings, Wang 6 in their meta-analysis have found that genotype GG is associated with significantly more susceptibility to pulmonary TB than both GC and CC genotypes. In agreement with the finding of the current study, it has been shown than genotype CC is associated with less risk of pulmonary tuberculosis.…”

Section: Discussionmentioning

confidence: 59%

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The Role of IL-6 Gene Polymorphism in Multidrug-Resistant Tuberculosis Patients in Iraq

Flaifel¹,

Al-Azawi²

2020

ijddt

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Background: Tuberculosis (TB) remains to be a leading cause of morbidity and mortality in developing countries, and the incidence of the disease is increasing in developed. One-third of the world’s population is infected by Mycobacterium tuberculosis (Mtb). Still, only about 5% of infected individuals develop the disease within the first year of infection, and another 5% develop the disease later in life. Aim of the study: Is to investigate the relationship between the levels of Interleukin 6 (IL-6) and detection of multidrug-resistant tuberculosis (MDR-TB) in Al-Diwaniyah population. Patients and methods: The current study included 120 patients with tuberculosis who were classified into two groups. The first group included 60 TB patients who were sensitive to anti TB drugs and 60 patients with multi-drug resistance (MDR) based on gene Xpert. The study also included 60 healthy individuals serving as a control group. Demographic characteristics of study and control groups were retrieved. IL-6 (-572G/C) genotype polymorphism was carried out using polymerase chain reaction (PCR) and according to the instruction of the providing company. Serum level of IL-6 was also measured by ELISA according to the instruction of the providing company. Results: It has been observed that genotype CC was more frequent in sensitive TB patients than both MDR TB patients and control subjects, 73.3 % versus 60 % and 61.7 %, respectively. Serum IL-6 level was significantly higher in MDR TB patients than in control group (p = 0.007), and there was no significant difference in its level between sensitive and MDR TB patients (p = 0.284). Conclusion: IL-6 gene polymorphism is not associated with multidrug resistance in TB patients; however, Serum IL-6 level was significantly higher in MDR TB patients than in the control group.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 59%

The Role of IL-6 Gene Polymorphism in Multidrug-Resistant Tuberculosis Patients in Iraq

Flaifel¹,

Al-Azawi²

2020

ijddt

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“…First, it may be due to a different genetic background, such as frequencies of the AA genotype at rs3805246. Also, different environmental factors can potentially induce various gene modifications [ 22 , 23 ]. Furthermore, gene SNPs differ in individual populations, regions, and races or ethnicities [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population

Chen

Zhao

Wu³

et al. 2021

Med Sci Monit

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Background The Gab1 gene has an important role in cell proliferation in meningioma via various signaling pathways. However, the relationship between polymorphisms of the Gab1 gene and meningioma remains unknown. In this study, we aimed to investigate the plausible association of single-nucleotide polymorphisms (SNPs) of the Gab1 gene and meningioma risk in a northern Chinese Han population. Material/Methods This case-control study included 205 patients with meningioma and 297 healthy controls. Four loci of the Gab1 gene were genotyped using the multiplex snapshot technique. The odds ratio (OR) and 95% confidence interval (CI) were calculated by chi-squared and logistic regression analysis. The distributions of Gab1 SNP genotypes and allele frequencies were compared between patients with meningioma and healthy controls and among patients stratified by clinical phenotypes. Results The allelic frequency distributions of G at rs3805236 and C at rs1397529 were significantly higher in patients with meningioma than in healthy controls. The frequency of the rs3805236-GG and rs1397529-AC genotypes were significantly higher in patients with meningioma than in controls. Furthermore, there was a statistically significant difference between the genotypes of patients versus healthy individuals at rs1397529, according to stratification by dural invasion. The allelic frequency distributions of alleles or genotypes at rs3805246 and rs3828512 were not different in patients with meningioma and healthy controls. Conclusions The Gab1 gene rs3805236A>G and rs1397529A>C SNPs increased the risk of meningioma in the northern Chinese Han population. Furthermore, rs1397529A>C may be related to enhanced dural invasion in patients with meningioma.

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“…Nevertheless, the previous study has provided important clues that the host genetics was indispensable for the development of TB [8]. Previous studies had reported that genetic variation of cytokines would be involved in the susceptibility to TB, such as interleukin 6 [9], interleukin 10 [10], and interleukin 17 [11]. Meanwhile, genetic polymorphism of the vitamin D receptor was also reported in association with TB [12].…”

Section: Introductionmentioning

confidence: 99%

A Common Variant of ASAP1 Is Associated with Tuberculosis Susceptibility in the Han Chinese Population

et al. 2019

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Background. ASAP1 (also known as AMAP1 or DDEF1) encodes an Arf GTPase-activating protein (Arf GAP), a multifunctional scaffold protein that induces hydrolysis of GTP bound to the ADP-ribosylation factor (Arf) family GTP-binding proteins. Reduction of ASAP1 expression in vitro was related to suppression of cell migration and invasiveness. The genetic variant rs4733781 of the ASAP1 gene was revealed as a significant locus for tuberculosis (TB) susceptibility, but the results still need to be validated. Methods. Blood samples from a total of 1914 active TB and healthy controls (HC) were collected to evaluate rs4733781 and the risk of TB. Meanwhile, a total of 48 noninfected HC, latent TB-infected (LTBI) controls, and active TB were collected to assay ASAP1 expression difference among the three groups. The QuantiFERON-TB Gold In-Tube was adopted to identify noninfected HC and LTBI. Results. The genetic variant of rs4733781 was found to be significantly associated with TB, and the A allele of rs4733781 (C>A) was 0.38 and 0.43 among TB cases and HC, respectively (P=0.0035). Meanwhile, the peripheral blood monocyte RNA fold changes for the ASAP1 gene among the 16 HC, 16 LTBI, and 16 active TB were 1.088±0.4919, 2.237±0.6505, and 10.12±10.98 (F=9.559, P=0.0003), respectively, and the expression of ASAP1 was increased by 2.06-fold (P<0.0001) and 9.30-fold (P<0.0052) for LTBI and active TB, when compared to the HC. Conclusions. Our data indicated that the A allele of rs4733781 for the ASAP1 gene was in association with a decreased risk of TB. But not only that, the overexpression of the ASAP1 gene among LTBI and TB was related to the progression of TB, which further implies that the expression of ASAP1 would be a potential biomarker for LTBI and TB diagnoses.

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Association between the <em>IL-6</em> gene polymorphism and tuberculosis risk: a meta-analysis

Cited by 10 publications

References 36 publications

The Role of IL-6 Gene Polymorphism in Multidrug-Resistant Tuberculosis Patients in Iraq

The Role of IL-6 Gene Polymorphism in Multidrug-Resistant Tuberculosis Patients in Iraq

Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population

A Common Variant of ASAP1 Is Associated with Tuberculosis Susceptibility in the Han Chinese Population

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