1967
DOI: 10.1001/archneur.1967.00470230044005
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Independence of Blood and Cerebrospinal Fluid Lactate

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Cited by 145 publications
(53 citation statements)
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“…The rostrocaudal gradient (RCG) of lactate was 0.82. We verified the earlier studies of Posner and Plum who found almost equal CSF lactate levels between the cisterns and lumbar thecal sac, and that of Vamosi et al who, similarly to us, found higher lumbar lactate levels when compared to cisternal levels [20,21].…”
Section: Discussionsupporting
confidence: 92%
“…The rostrocaudal gradient (RCG) of lactate was 0.82. We verified the earlier studies of Posner and Plum who found almost equal CSF lactate levels between the cisterns and lumbar thecal sac, and that of Vamosi et al who, similarly to us, found higher lumbar lactate levels when compared to cisternal levels [20,21].…”
Section: Discussionsupporting
confidence: 92%
“…The concentration of LA in brain is dependent directly upon its rate of production. There is evidence, from patients and animal studies, that blood and CSF lactate concentrations are largely independent of each other (13,33). This is a very important characteristic of LA and offers an advantage over CSF glucose determination since CSF glucose is related to blood glucose.…”
Section: Figure 1 Csf Lactic Acid (Mmol/l) Concentration In the Studimentioning
confidence: 99%
“…Most patients with bacterial meningitis have concentrations above 3.5 mmol/L, with some values )11 mmol/L (100 mg/dL) (13,(20)(21)(22)31).…”
Section: Figure 1 Csf Lactic Acid (Mmol/l) Concentration In the Studimentioning
confidence: 99%
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“…It has previously been demonstrated lactate cannot easily cross the bloodbrain barrier (Hertz andDienel, 2002 andAuer, 1986), infusing lactate intravenously does not increase CSF lactate (Alexander et al, 1962) and levels of blood and CSF lactate are regulated independently (Posner and Plum, 1967). However, others have documented that the blood-brain barrier is permeable to lactate (Dalsgaard et al, 2004, Smith et al, 2003and Oldendorf, 1973 and the lactate transporter MCT1 is expressed on endothelial cells (Gerhart et al, 1997).…”
Section: From the Bloodmentioning
confidence: 99%