Indel mutation of the ADD1/SREBP-1c gene in the South Anatolian Red and East Anatolian Red cattle breeds

ÖZTABAK, KEMAL ÖZDEM; AKAD, IRAZ AKIŞ; Gürsel, Feraye Esen; Ateş, Atila; YARDİBİ, HASRET; HOŞTÜRK, GÜLHAN TÜRKAY

doi:10.3906/vet-1111-24

Cited by 3 publications

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“…(2007) identified an interesting 84 bp insertion/deletion polymorphism (84 bp‐indel; rs133958066) of intron 5 of SREBP1 , which was associated with higher monounsaturated FA (MUFA) content and lower melting point of intramuscular fat. This polymorphism has been widely investigated in cattle breeds such as Holstein‐Friesian, Hereford and Angus, as well as in Bos indicus and other local breeds (Kaneda et al., 2011; Öztabak et al., 2013; Proskura, 2013). The 84 bp‐indel has also been associated with growth traits (Huang et al., 2011) and milk production (Proskura et al., 2017), while some other studies have investigated its association with FA composition of backfat and muscle (Barton et al., 2010; Han et al., 2013; Lee et al., 2013; Matsuhashi et al., 2011; Xu et al., 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Hoashi et al (2007) identified an interesting 84 bp insertion/deletion polymorphism (84 bp-indel; rs133958066) of intron 5 of SREBP1, which was associated with higher monounsaturated FA (MUFA) content and lower melting point of intramuscular fat. This polymorphism has been widely investigated in cattle breeds such as Holstein-Friesian, Hereford and Angus, as well as in Bos indicus and other local breeds (Kaneda et al, 2011;Öztabak et al, 2013;Proskura, 2013).…”

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confidence: 99%

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Effect of a genetic polymorphism in SREBP1 on fatty acid composition and related gene expression in subcutaneous fat tissue of beef cattle breeds

Gamarra

Aldai

Arakawa

et al. 2021

Animal Science Journal

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It is widely recognized the beneficial effects of unsaturated fatty acids (UFA) in human health, which has been also emphasized by the World Health Organization (Burlingame et al., 2009;Vannice & Rasmussen, 2014). Thus, enhancing the UFA profile in animal-derived products improves the nutritional quality of them (Brooks et al., 2011).In terms of polyunsaturated fatty acids (PUFA), n-3, and n-6 are the most common, being linoleic (18:2n-6) and α-linolenic (18:3n-3) acids the most abundant. However, humans are unable to synthesize them and, therefore, they are considered essential dietary fatty acids (FA).Lipogenesis is nutritionally controlled at the transcriptional level by a common family of transcription factors designated sterol regulatory element binding proteins (SREBPs;. These transcription factors have an important role in controlling around 30 genes affecting the synthesis of FAs, triacylglycerols, and glycerophospholipids (Shimomura et al., 1997;Zimin et al., 2009), and are considered also master regulators of cholesterogenesis (Eberlé et al., 2004).

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of a genetic polymorphism in SREBP1 on fatty acid composition and related gene expression in subcutaneous fat tissue of beef cattle breeds

Gamarra

Aldai

Arakawa

et al. 2021

Animal Science Journal

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Genetic analysis of milk production and lactation period in Holstein cows according to BTN1A1 Gene Polymorphism

Senekal,

Al-Waith,

Al-Anbari

et al. 2023

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The results showed that the Holstein BTN1A1gene has two alleles (A allele ) which is superior to the second allele (B allele )in the two values of the substitution effect and the average effect of the allele, and the homo genotype AA over the hetero genotype AB was successful in the breeding value of the two traits. It was also revealed through the new equations that the gene is responsible for the characteristic of milk production of the total output and the amount of 37725 Iraqi dinars of the full value of the milk price, and it also affects by ±7.24 days of the length of the milking season, which is estimated at 3583.8 Iraqi dinars. It is responsible for the inheritance of 70.09 kg of total milk production for 6.35 days/season length, reflecting the product's price value.The possibility of adopting the BTN1A1 gene within the selection programs to improve some productive traits, as well as the possibility of conducting a comparison between genes on the basis of the new equations, determining their contribution to the studied traits, and choosing the most influential gene to be an effective marker in the selection of quantitative traits. Keywords: Genetic analysis, Milk production, length of lactation, Holstein cows, BTN1A1 gene

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Polymorphism in the SREBP-1 gene is associated with milk production traits of Jersey cattle

PROSKURA

Dybus

Zaborski

et al. 2017

Indian J of Anim Sci

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The sterol regulatory element-binding protein-1 (SREBP- 1) gene has been indicated to be linked to milk production traits in cattle, especially to milk fat yield and fatty acid composition. The transcription factor encoded by this gene is involved in the regulation of fat metabolism, so it is supposed that the variability of the SREBP-1 gene could influence these traits. The aim of this study was to analyze the association between the 84-bp insertion/deletion polymorphism of the SREBP-1 gene and milk production traits in Jersey cattle. The study found significant associations of the SREBP-1 gene polymorphism with fat content in the first lactation and protein content in the first three lactations analyzed both individually and together. In all cases, the LL genotype was linked to the higher value of the analyzed traits.

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Indel mutation of the ADD1/SREBP-1c gene in the South Anatolian Red and East Anatolian Red cattle breeds

Cited by 3 publications

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Effect of a genetic polymorphism in SREBP1 on fatty acid composition and related gene expression in subcutaneous fat tissue of beef cattle breeds

Effect of a genetic polymorphism in SREBP1 on fatty acid composition and related gene expression in subcutaneous fat tissue of beef cattle breeds

Genetic analysis of milk production and lactation period in Holstein cows according to BTN1A1 Gene Polymorphism

Polymorphism in the SREBP-1 gene is associated with milk production traits of Jersey cattle

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