Indaziflam: a new cellulose‐biosynthesis‐inhibiting herbicide provides long‐term control of invasive winter annual grasses

Sebastian, Derek J.; Fleming, Margaret B.; Patterson, Eric; Sebastian, James R.; Nissen, Scott J.

doi:10.1002/ps.4594

Cited by 50 publications

(93 citation statements)

References 58 publications

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“…These herbicides can suppress invasive annual grasses for 1 to 3 yr. However, these herbicides can damage desired annual forage grasses growing with invasive annual grasses (Jeffries et al 2016;Kyser et al 2007), and with the possible exception of indaziflam (Sebastian et al 2016b(Sebastian et al , 2017a, the damage risks extend to perennial forage grasses as well (Lym and Kirby 1991;Monaco et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Timing Aminopyralid to Prevent Seed Production Controls Medusahead (Taeniatherum caput-medusae) and Increases Forage Grasses

Rinella

Davy²,

Kyser

et al. 2018

Invasive plant sci. manag.

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Exotic annual grasses such as medusahead [Taeniatherum caput-medusae (L.) Nevski] and downy brome (Bromus tectorum L.) dominate millions of hectares of grasslands in the western United States. Applying picloram, aminopyralid, and other growth regulator herbicides at late growth stages reduces seed production of most exotic annual grasses. In this study, we applied aminopyralid to T. caput-medusae to determine how reducing seed production in the current growing season influenced cover in the subsequent growing season. At eight annual grassland sites, we applied aminopyralid at 55, 123, and 245 g ae ha −1 in spring just before T. caput-medusae heading. The two higher rates were also applied pre-emergence (PRE) in fall to allow comparisons with this previously tested timing. When applied in spring during the roughly 10-d period between the flag leaf and inflorescence first becoming visible, just 55 g ae ha −1 of aminopyralid greatly limited seed production and subsequently reduced T. caput-medusae cover to nearly zero. Fall aminopyralid applications were less effective against T. caput-medusae, even at a rate of 245 g ae ha −1 . The growing season of application, fall treatments, but not spring treatments, sometimes reduced cover of desirable winter annual forage grasses. The growing season after application, both spring and fall treatments tended to increase forage grasses, though spring treatments generally caused larger increases. Compared with other herbicide treatment options, preheading aminopyralid treatments are a relatively inexpensive, effective approach for controlling T. caput-medusae and increasing forage production.

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Section: Introductionmentioning

confidence: 99%

Timing Aminopyralid to Prevent Seed Production Controls Medusahead (Taeniatherum caput-medusae) and Increases Forage Grasses

Rinella

Davy²,

Kyser

et al. 2018

Invasive plant sci. manag.

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“…Fluorescence microscopy confirmed the inhibition of cellulose biosynthesis following indaziflam treatment, as well as aberrant root and cell morphology. Indaziflam increases the density of large cellulose synthase particles at the plasma membrane and reduces particle velocity, resulting in the inhibition of polymerization …”

Section: Chiral Herbicidesmentioning

confidence: 99%

“…As the strongest innovative alkylazine herbicide, indaziflam has broad control of both grasses and broadleaf weeds (application rates of ∼ 50–75 g ha −1 ) that are resistant to other herbicidal modes of action. Its increased activity on monocotyledonous weeds provides a new alternative strategy for the long‐term control of multiple invasive winter annual grasses . To date, there is no evidence of any cross‐resistance.…”

Section: Chiral Herbicidesmentioning

confidence: 99%

“…Indaziflam increases the density of large cellulose synthase particles at the plasma membrane and reduces particle velocity, resulting in the inhibition of polymerization. 37 A useful synthesis with enantioselective access to the trans-(1R,2S)-indanylamine has been established, involving a novel dynamic kinetic resolution followed by a nucleophilic substitution reaction (Fig. S4).…”

Section: Cellulose Biosynthesis Inhibitorsmentioning

confidence: 99%

“…Its increased activity on monocotyledonous weeds provides a new alternative strategy for the long-term control of multiple invasive winter annual grasses. 37 To date, there is no evidence of any cross-resistance.…”

Section: Cellulose Biosynthesis Inhibitorsmentioning

confidence: 99%

See 2 more Smart Citations

Current status of chirality in agrochemicals

Jeschke

2018

Pest Management Science

147

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The agrochemical industry is searching continuously for new pesticides to develop products that have optimal efficacy, lower application rates in the field, increased selectivity, favourable toxicological and environmental safety, enhanced user friendliness and better economic viability. One strategy by which to achieve these ambitious goals makes use of the unique properties of molecules containing asymmetric centres. In the past, many natural products and their congeners have been a source of inspiration in the design of new active ingredients, and the molecular structures of the resulting compounds have become increasingly complex; some 30% contain fragments with asymmetric centres. However, despite enormous progress in catalytic asymmetric processes over the past decade, few agrochemicals are produced in an enantiomerically pure or enriched form on an industrial scale. Since 2007, ∼ 43% of the 44 products launched (insecticides, acaricides, fungicides, nematicides and herbicides) contain one or more asymmetric centres in the molecule (∼ 47%) and most have been launched as racemic mixtures of enantiomers or diastereomers. This review provides an overview of the current status of chiral agrochemicals launched over the past 10 years and describes the inherently connected challenges of modern agricultural chemistry by managing important aspects resulting from the stereochemistry of these innovative products. © 2018 Society of Chemical Industry.

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Herbicide effects on the establishment of a native bunchgrass in annual grass invaded areas: Indaziflam versus imazapic

Terry

Madsen

Gill

et al. 2021

Ecol Sol and Evidence

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1. Annual grass invasion is transforming the western United States and driving a need for restoration techniques that can both reduce exotic annual grass abundance and allow revegetation of native species. Pre-emergent herbicides can provide control of annual grasses, but when applied concurrently with direct seeding efforts, the herbicide can also impact seeded species. Indaziflam is a relatively new herbicide that may provide extended control of exotic annual grasses, but little is known about its effects when applied at the time of seeding. 2. In this study, we compared indaziflam to imazapic, a popular herbicide used in restoration efforts, to understand how indaziflam affects plant establishment of a native species, bluebunch wheatgrass Pseudoroegneria spicata (Pursh) Á. Löve. We created furrows on half our treatments to limit herbicide concentrations and potentially create a safe-site for seeding bluebunch wheatgrass. 3. During the 2-year study, indaziflam provided consistent control of the annual weed, downy brome Bromus tectorum L., whereas imazapic control decreased sharply with time. Indaziflam and imazapic decreased bluebunch wheatgrass seedling emergence by 96% and 46%, and 2-year plant density by 91% and 65%, respectively, compared to non-herbicide treatments. Both herbicides reduced aboveground biomass of bluebunch wheatgrass by over 85% 2 years after seeding/herbicide application. 4. Furrow treatments mitigated imazapic's effect on bluebunch wheatgrass, but did not limit the impacts by indaziflam. 5. Herbicide can be used in conjunction with direct seeding efforts, but mitigation of the effects to native seeds will depend on herbicide specifics such as mode of action and soil mobility.

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Indaziflam: a new cellulose‐biosynthesis‐inhibiting herbicide provides long‐term control of invasive winter annual grasses

Cited by 50 publications

References 58 publications

Timing Aminopyralid to Prevent Seed Production Controls Medusahead (Taeniatherum caput-medusae) and Increases Forage Grasses

Timing Aminopyralid to Prevent Seed Production Controls Medusahead (Taeniatherum caput-medusae) and Increases Forage Grasses

Current status of chirality in agrochemicals

Herbicide effects on the establishment of a native bunchgrass in annual grass invaded areas: Indaziflam versus imazapic

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