1983
DOI: 10.1016/s0140-6736(83)91395-8
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Incubation Period and Other Features of Food-Borne and Water-Borne Outbreaks of Typhoid Fever in Relation to Pathogenesis and Genetics of Resistance

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Cited by 27 publications
(15 citation statements)
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“…Typhoid fever is a disease which requires new approaches for chemotherapy to overcome the problems of drug resistance and high relapse rates with this illness in different parts of the world (3,11,21,25,43). Plasmid-mediated resistance to chloramphenicol, ampicillin, and other agents presently used to treat systemic salmonellosis is an ever-present problem.…”
Section: Discussionmentioning
confidence: 99%
“…Typhoid fever is a disease which requires new approaches for chemotherapy to overcome the problems of drug resistance and high relapse rates with this illness in different parts of the world (3,11,21,25,43). Plasmid-mediated resistance to chloramphenicol, ampicillin, and other agents presently used to treat systemic salmonellosis is an ever-present problem.…”
Section: Discussionmentioning
confidence: 99%
“…Thus in water-borne outbreaks of typhoid fever with low attack rates and long incubations the oral infective dose has been estimated as less than 1000 bacteria.329 33 A possible reason why S. typhi can commonly infect from such small doses may be that it has a specific ability to colonise the human throat and thence seed large numbers of bacteria into the stomach and intestine.…”
Section: Size Of Oral Infective Dosementioning
confidence: 99%
“…The incubation period for S. typhi is usually between 5 and 21 days 4 but up to 60 days has been described 5 . One study, giving a low dose of the Quailes strain of S. typhi in milk to 1886 inmate volunteers showed incubation periods varying from 3 to 41 days, with an attack rate of 35% 8 . The incubation period is dependent on the inoculating dose, the virulence of the individual strain and host factors.…”
Section: Discussionmentioning
confidence: 99%