Incremental value of normal adenosine perfusion cardiac magnetic resonance: Long-term outcome

Sozzi, Fabiola B.; Iacuzio, Laura; Civaia, Filippo; Canetta, Ciro; Berthier, F.; Rusek, Stephane; Rossi, P; Lombardi, Federico; Dreyfus, Gilles; Dor, Vincent

doi:10.1016/j.ahj.2015.03.001

Cited by 7 publications

(2 citation statements)

References 39 publications

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“…Exploring predictors of all-cause mortality, we unexpectedly found that stress-induced perfusion abnormalities at CMR are not independently correlated with prognosis. This finding was quite unpredicted if we consider (1) the good sensitivity and specificity shown by SPCMR for ischemia detection, also in comparison with established imaging techniques like single photon emission tomography [ 10 ]; (2) the results of a recent publication demonstrating the utility of SPCMR to reclassify patient risk beyond standard clinical variables (in particular those at moderate/high pretest risk) [ 14 ]; (3) numerous publications, summarized in recent meta-analyses [ 9 , 15 ], showing a significant prognostic value of SPCMR.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling

Catalano

Moro

Mori

et al. 2018

BioMed Research International

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Aims Cardiovascular magnetic resonance (CMR) permits a comprehensive evaluation of stable coronary artery disease (CAD). We sought to assess whether, in a large contemporaneous population receiving optimal medical therapy, CMR independently predicts prognosis beyond conventional cardiovascular risk factors (RF). Methods We performed a single centre, observational prospective study that enrolled 465 CAD patients (80% males; 63±11 years), optimally treated with ACE-inhibitors/ARB, aspirin, and statins (76-85%). Assessments included conventional evaluation (clinical history, atherosclerosis RF, electrocardiography, and echocardiography) and a comprehensive CMR with LV dimensions/function, late gadolinium enhancement (LGE), and stress perfusion CMR (SPCMR). Results During a median follow-up of 62 months (IQR 23-74) there were 50 deaths and 92 major adverse cardiovascular events (MACE). CMR variables improved multivariate model prediction power of mortality and MACE over traditional RF alone (F-test p<0.05 and p<0.001, respectively). LGE was an independent prognostic factor of mortality (hazard ratio [95% CI]: 3.4 [1.3−8.8]); moreover, LGE (3.3 [1.7−6.3]) and SPCMR (2.1 [1.4−3.2]) were the best predictors of MACE. Conclusion LGE is an independent noninvasive marker of mortality in the long term in patients with stable CAD and optimized medical therapy. Furthermore, LGE and SPCMR independently predict MACE beyond conventional risk stratification.

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Section: Discussionmentioning

confidence: 99%

Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling

Catalano

Moro

Mori

et al. 2018

BioMed Research International

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“…Many studies have been published regarding the assessment of prognosis with stress-CMR [ 94 , 95 ]. Sozzi et al, showed that among 326 consecutive patients with normal adenosine stress perfusion CMR the event rate was low and prognosis excellent over a 5.5-year period [ 96 ]. Kelle et al found that, in a large cohort of patients with negative dobutamine stress, the annual cardiac event rate was 1.1% while the hazard ratio associated with a positive test was 3.3 [ 97 ].…”

Section: Prognosismentioning

confidence: 99%

Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease

Baritussio

Scatteia

Bucciarelli-Ducci

2017

Int J Cardiovasc Imaging

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Cardiovascular magnetic resonance (CMR) is a multi-parametric, multi-planar, non-invasive imaging technique, which allows accurate determination of biventricular function and precise myocardial tissue characterization in a one-stop-shop technique, free from the use of ionizing radiations. Though CMR has been increasingly applied over the last two decades in every-day clinical practice, its widest application has been in the assessment of ischemic cardiomyopathy.

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Myokardiale Perfusionsdiagnostik der koronaren Herzerkrankung

2015

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Incremental value of normal adenosine perfusion cardiac magnetic resonance: Long-term outcome

Cited by 7 publications

References 39 publications

Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling

Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic Value to Conventional Risk Profiling

Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease

Myokardiale Perfusionsdiagnostik der koronaren Herzerkrankung

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