Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease

Baritussio, Anna; Scatteia, Alessandra; Bucciarelli-Ducci, Chiara

doi:10.1007/s10554-017-1116-0

Cited by 34 publications

(39 citation statements)

References 102 publications

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“…MRM quantification revealed differences in T2 and T2* values between chronic and acute infarct samples. Haematoxylin-eosin staining revealed a heterogeneous tissue composition (oedema, necrosis, and inflammatory infiltrate) in the acute phase 2 , which may explain the high intra- and inter-sample heterogeneity detected in the acute infarct model. In contrast, as found in previous studies 16–18 , in chronic infarct samples oedema had already vanished and a homogeneous scar with high collagen content (as shown from picrosirius red stain) had substituted most of the damaged tissue.…”

Section: Discussionmentioning

confidence: 94%

“…Delayed enhancement cardiovascular magnetic resonance (MR) is the most used imaging technique for comprehensive non-invasive assessment of the structural consequences of myocardial infarction (MI) in patients 1 . However, limitations to the use of contrast in cardiovascular MR include the risk of side effects and the length of the studies 2 . Therefore, it seems important to advance towards contrast agent-free, histologically-validated cardiovascular MR biomarkers.…”

Section: Introductionmentioning

confidence: 99%

“…T1-weighted images show the cardiac anatomic structure, T1 values rise with increased extracellular volume, while T2-weighted images are related with the magnitude of the myocardial oedema 3,4 . Novel sequences recently incorporated into the clinical armamentarium are designed to indirectly evaluate fibrotic tissue (T1-post contrast and extracellular volume fraction), the presence of oedema during the acute post-MI phase (T1-mapping 5,6 ), and the extent of haemorrhage in the infarcted area (T2*-mapping 2 ). Despite the benefits provided by endogenous contrast in T1, T2, and T2* images and the design of new sequences, gadolinium-enhanced cardiac MR remains the routine tool in Post-Infarction imaging.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic resonance microscopy and correlative histopathology of the infarcted heart

Perez-Terol

Ríos‐Navarro

Dios

et al. 2019

Sci Rep

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Delayed enhancement cardiovascular magnetic resonance (MR) is the gold-standard for non-invasive assessment after myocardial infarction (MI). MR microscopy (MRM) provides a level of detail comparable to the macro objective of light microscopy. We used MRM and correlative histopathology to identify infarct and remote tissue in contrast agent-free multi-sequence MRM in swine MI hearts. One control group (n = 3 swine) and two experimental MI groups were formed: 90 min of ischemia followed by 1 week (acute MI = 6 swine) or 1 month (chronic MI = 5 swine) reperfusion. Representative samples of each heart were analysed by contrast agent-free multi-sequence (T1-weighting, T2-weighting, T2*-weighting, T2-mapping, and T2*-mapping). MRM was performed in a 14-Tesla vertical axis imager (Bruker-AVANCE 600 system). Images from MRM and the corresponding histopathological stained samples revealed differences in signal intensities between infarct and remote areas in both MI groups (p-value < 0.001). The multivariable models allowed us to precisely classify regions of interest (acute MI: specificity 92% and sensitivity 80%; chronic MI: specificity 100% and sensitivity 98%). Probabilistic maps based on MRM images clearly delineated the infarcted regions. As a proof of concept, these results illustrate the potential of MRM with correlative histopathology as a platform for exploring novel contrast agent-free MR biomarkers after MI.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Magnetic resonance microscopy and correlative histopathology of the infarcted heart

Perez-Terol

Ríos‐Navarro

Dios

et al. 2019

Sci Rep

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“…The role of CMR for imaging ischemic heart disease was reviewed [64,65]. Incomplete coverage of the left ventricle using three short axis slices was not found adversely affect diagnostic accuracy compared with a whole heart assessment but may fail to detect apical ischemia and underestimate the extent and severity of perfusion defects [66].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Cardiovascular imaging 2018 in the International Journal of Cardiovascular Imaging

Reiber

Pereira

Bezerra

et al. 2019

Int J Cardiovasc Imaging

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“…The severity of myocardial infarction (MI) is a determining factor of left ventricular (LV) dysfunction and long-term remodeling in post-ST-segment-elevation MI (STEMI) patients undergoing primary percutaneous https://doi.org/10.3348/kjr.2019.0969 kjronline.org size, microvascular obstruction [MVO], transmurality, and myocardium rescue), the most appropriate parameter is still not definitively agreed on (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Radiomics of Non-Contrast-Enhanced T1 Mapping: Diagnostic and Predictive Performance for Myocardial Injury in Acute ST-Segment-Elevation Myocardial Infarction

Takata

et al. 2021

Korean J Radiol

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Objective: To evaluate the feasibility of texture analysis on non-contrast-enhanced T1 maps of cardiac magnetic resonance (CMR) imaging for the diagnosis of myocardial injury in acute myocardial infarction (MI). Materials and Methods: This study included 68 patients (57 males and 11 females; mean age, 55.7 ± 10.5 years) with acute ST-segment-elevation MI who had undergone 3T CMR after a percutaneous coronary intervention. Forty patients of them also underwent a 6-month follow-up CMR. The CMR protocol included T2-weighted imaging, T1 mapping, rest first-pass perfusion, and late gadolinium enhancement. Radiomics features were extracted from the T1 maps using open-source software. Radiomics signatures were constructed with the selected strongest features to evaluate the myocardial injury severity and predict the recovery of left ventricular (LV) longitudinal systolic myocardial contractility. Results: A total of 1088 segments of the acute CMR images were analyzed; 103 (9.5%) segments showed microvascular obstruction (MVO), and 557 (51.2%) segments showed MI. A total of 640 segments were included in the 6-month follow-up analysis, of which 160 (25.0%) segments showed favorable recovery of LV longitudinal systolic myocardial contractility. Combined radiomics signature and T1 values resulted in a higher diagnostic performance for MVO compared to T1 values alone (area under the curve [AUC] in the training set; 0.88, 0.72, p = 0.031: AUC in the test set; 0.86, 0.71, p = 0.002). Combined radiomics signature and T1 values also provided a higher predictive value for LV longitudinal systolic myocardial contractility recovery compared to T1 values (AUC in the training set; 0.76, 0.55, p < 0.001: AUC in the test set; 0.77, 0.60, p < 0.001). Conclusion: The combination of radiomics of non-contrast-enhanced T1 mapping and T1 values could provide higher diagnostic accuracy for MVO. Radiomics also provides incremental value in the prediction of LV longitudinal systolic myocardial contractility at six months.

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Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease

Cited by 34 publications

References 102 publications

Magnetic resonance microscopy and correlative histopathology of the infarcted heart

Magnetic resonance microscopy and correlative histopathology of the infarcted heart

Cardiovascular imaging 2018 in the International Journal of Cardiovascular Imaging

Radiomics of Non-Contrast-Enhanced T1 Mapping: Diagnostic and Predictive Performance for Myocardial Injury in Acute ST-Segment-Elevation Myocardial Infarction

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