Due to the spread of multiple variants of COVID-19, the influence of humidity and temperature on their transmission and spread is a matter of scientific investigation. This research investigates the connection of relative humidity and daily high temperature with the quantity of daily definite COVID-19 cases in Punjab, Pakistan from March 11, 2020 to June 30, 2020. Generalized Additive Model (GAM) was applied to measure the said association. In this study, the interaction of relative humidity and temperature were discussed and the results indicated that the growth in humidity and temperature leads to a decline in the daily occurrence of cases. On the basis of the findings, the development and implementation of a proficient and effective health care information system are recommended so that the frequency and transmission of COVID-19 can be curtailed.Keywords: COVID-19, Generalized Additive Model, humidity, temperatureJelCode: C140, I120, I180, Q24