Increasing the noninvasive management of rhesus isoimmunization

Papantoniou, Nikolaos; Anastasakis, Eleftherios; Marinopoulos, Spyridon S; Mesogitis, S.; Antsaklis, Aris

doi:10.1016/j.ijgo.2007.11.021

Cited by 8 publications

(6 citation statements)

References 17 publications

(19 reference statements)

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“…This knowledge allowed us to modulate modern management of the Rh-affected pregnancies with the determination of fetal RhD genotype with the use of cellfree fetal DNA and the follow-up of antigen-positive fetuses [33,60,77] . The latter is successfully carried out with the use of Doppler, evaluating the peak systolic velocity in the middle cerebral artery (MCA-PSV), which is considered to be the most reliable tool to provide sensitive prediction of the severity of fetal anemia.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic management of fetal anemia: review of standard practice and alternative treatment options

Παπαντωνίου

Sifakis

Antsaklis

2012

Journal of Perinatal Medicine

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Fetal anemia, mainly due to red cell alloimmunization, is still a signifi cant cause of fetal and neonatal mortality and morbidity. The focus of current clinical research has shifted from an invasive approach to non-invasive management and treatment of affected pregnancies, and the progress in this fi eld is associated with a major improvement in perinatal outcome. During the last 50 years, intrauterine red cells transfusion (IUT), fi rst via the intraperitoneal route and later directly to fetal circulation, is the standard practice in most centers, with survival rates that exceed 90 % , particularly if anemia is diagnosed early and treated in a timely manner. In addition, plasmapheresis and intravenous administration of highdose immunoglobulin have been implicated in the treatment of pregnancies complicated with early-onset severe red cell alloimmunization, alone or in combination with IUTs before the 20 th week of pregnancy, but there are still issues to be clarifi ed further. This review article aims to provide an overview of the current standard therapeutic management and alternative treatment modalities in pregnancies complicated by fetal anemia.

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Section: Introductionmentioning

confidence: 99%

Therapeutic management of fetal anemia: review of standard practice and alternative treatment options

Παπαντωνίου

Sifakis

Antsaklis

2012

Journal of Perinatal Medicine

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“…MCA-PSV calculation was the only method to assess fetal anemia as it correlated well with fetal Hb & delta OD 450 findings (Liley curve) [3]. Up to 34 wks sensitivity of detecting fetal anaemia is predicted 100% by MCA-PSV [4]. Fetal surveillance by CTG was performed.…”

Section: Discussionmentioning

confidence: 99%

Rh Isoimmunized Pregnancy—Do Maternal Antibody Titre Always Correlate with the Fetal Affection? A Non-Invasive Management

Shukla¹,

Shukla²,

Valia³

et al. 2018

OJOG

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This case is of Rh −ve 2 nd gravida having antibody titre detected 1:2 at 8 weeks of 2 nd pregnancy. Serial antibody titre carried out along with clinical examination. Fetal monitoring was done by assessing MCA-PSV (Middle cerebral artery peak systolic velocity) and CTG (Cardiotocograph) when required. Pregnancy was terminated when the titre reached 1:512 at 34 wks of pregnancy with abnormal MCA-PSV values. Neonate just had begun to show sign of anaemia & haemolysis at birth.

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“…L'analyse du PSV-ACM est un bon indicateur d'anémie foetale [4]. Cependant, la corrélation entre la gravité de l'anémie et l'accélération du PSV-ACM n'est pas toujours suffisamment précise.…”

Section: Discussionunclassified

“…De façon plus récente, la mesure du PSV-ACM s'est révélée être un bon élément prédictif de l'anémie foetale [4]. Elle est considérée comme augmentée et à risque d'anémie sévère lorsqu'elle est supérieure ou égale à 1,5 fois la médiane pour un terme donné [5].…”

Section: Données Générales Et Anténatalesunclassified

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Prise en charge périnatale et devenir neurologique à moyen terme des nouveau-nés hospitalisés pour maladie hémolytique par immunisation anti-D

Gobalakichenane

Galène-Gromez

Brossard

et al. 2008

Gynécologie Obstétrique & Fertilité

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Increasing the noninvasive management of rhesus isoimmunization

Abstract: Management by MCA-PSV Doppler at weekly intervals is a highly sensitive method for detecting fetal anemia. It reduces the number of fetal blood samples needed and significantly lowers interventional procedures.

Cited by 8 publications

References 17 publications

Therapeutic management of fetal anemia: review of standard practice and alternative treatment options

Therapeutic management of fetal anemia: review of standard practice and alternative treatment options

Rh Isoimmunized Pregnancy—Do Maternal Antibody Titre Always Correlate with the Fetal Affection? A Non-Invasive Management

Prise en charge périnatale et devenir neurologique à moyen terme des nouveau-nés hospitalisés pour maladie hémolytique par immunisation anti-D

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