Increasing risk of congenital anomalies associated with seasonal pattern of air pollution: Differences by maternal comorbidities

Zhao, Boyi; Wang, Min; Lü, Changwei; Meng, Haixia; Fan, Qingyun; Guo, Jing; Wang, Wenqing; Wang, Haoji; Zhou, Haijun; He, Jing

doi:10.1016/j.ecoenv.2018.10.037

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…Our study expanded the window of observation, allowing temporal associations to be clari ed. Zhao et al also reported that CO exposure levels were associated with the risks of congenital anomalies in 1st trimester [41]. The above studies are consistent with the results of this study, suggesting that atmospheric CO pollution after pregnancy may increase the risk of BDs.…”

Section: Discussionsupporting

confidence: 91%

The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China

Huang

Chen

Zeng

et al. 2020

Preprint

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Background: Studies suggest that exposure to ambient air pollution during pregnancy may be associated with increased risks of birth defects (BDs), but conclusions have been inconsistent. This study describes the ethnic distribution of major BDs and examines the relationship between air pollution and BDs among different ethnic groups in Liuzhou city, China.Methods: Surveillance data of infants born in 114 registered hospitals in Liuzhou in 2019 were analyzed to determine the epidemiology of BDs across five major ethnic groups. Concentrations of six air pollutants (PM2.5, PM10, SO2, CO, NO2, O3) were obtained from the Liuzhou Environmental Protection Bureau. Logistic regression was used to examine the associations between ambient air exposure and risk of BDs.Results: Among 32,549 infants, 635 infants had BDs, yielding a prevalence of 19.5 per 1000 perinatal infants. Dong ethnic group had the highest prevalence of BDs (2.59%), followed by Yao (2.57%), Miao (2.35%), Zhuang (2.07%), Han (1.75%). Relative to the Han ethnic group, Zhuang, Miao, Yao and Dong groups had lower risks of congenital heart disease, polydactyly, and hypospadias. The Zhuang ethnic group had higher risks of severe thalassemia, cleft lip and/or palate, and syndactyls. Our analysis of the correlation between air pollution and BDs showed that BDs were positively correlated with air pollutants PM10 (aORs =1.14; 95% CI:1.12-2.43 for per 10ug/mg3 increment) and CO (aORs =1.36; 95% CI:1.14-2.48 for every 1mg /m3 increment) in second month of pregnancy, and were associated with PM10 (aORs =1.51; 95% CI:1.13-2.03) and CO (aORs =1.75; 95%CI:1.02-3.61) in the third month of pregnancy. SO2 also had a significant association with BDs in the second month of the pregnancy (aORs =1.31; 95% CI:1.20-3.22) and third month of pregnancy (aORs =1.75; 95% CI:1.02-3.61). However, no signiﬁcant association was found between birth defects and O3, PM2.5 and NO2 (P > 0.05). Conclusion: This study provided a comprehensive description of ethnic differences in BDs in Southwest China, and broadens the evidence of association between air pollution exposure during gestation and BDs.

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Section: Discussionsupporting

confidence: 91%

The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China

Huang

Chen

Zeng

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Our study expanded the window of observation, allowing temporal associations to be clarified. Zhao et al also reported that CO exposure levels were associated with the risks of congenital anomalies in 1st trimester [ 41 ]. The above studies are consistent with the results of this study, suggesting that atmospheric air pollution before and during pregnancy may increase the risk of BDs.…”

Section: Discussionmentioning

confidence: 99%

The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China

et al. 2021

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Background Studies suggest that exposure to ambient air pollution during pregnancy may be associated with increased risks of birth defects (BDs), but conclusions have been inconsistent. This study describes the ethnic distribution of major BDs and examines the relationship between air pollution and BDs among different ethnic groups in Liuzhou city, China. Methods Surveillance data of infants born in 114 registered hospitals in Liuzhou in 2019 were analyzed to determine the epidemiology of BDs across five major ethnic groups. Concentrations of six air pollutants (PM2.5, PM10, SO2, CO, NO2, O3) were obtained from the Liuzhou Environmental Protection Bureau. Logistic regression was used to examine the associations between ambient air pollution exposure and risk of BDs. Results Among 32,549 infants, 635 infants had BDs, yielding a prevalence of 19.5 per 1000 perinatal infants. Dong ethnic group had the highest prevalence of BDs (2.59%), followed by Yao (2.57%), Miao (2.35%), Zhuang (2.07%), and Han (1.75%). Relative to the Han ethnic group, infants from Zhuang, Miao, Yao and Dong groups had lower risks of congenital heart disease, polydactyly, and hypospadias. The Zhuang ethnic group had higher risks of severe thalassemia, cleft lip and/or palate, and syndactyls. Overall BDs were positively correlated with air pollutants PM10 (aOR =1.14, 95% CI:1.12 ~ 2.43; aOR =1.51, 95% CI:1.13 ~ 2.03 for per 10μg/mg3 increment) and CO (aOR =1.36, 95% CI:1.14 ~ 2.48; aOR =1.75, 95% CI:1.02 ~ 3.61 for every 1 mg /m3 increment) in second and third month of pregnancy. SO2 was also significantly associated with BDs in the second month before the pregnancy (aOR = 1.31; 95% CI: 1.20 ~ 3.22) and third month of pregnancy (aOR =1.75; 95% CI:1.02 ~ 3.61). Congenital heart disease, polydactyl, cleft lip and/or palate were also significantly associated with PM10, SO2 and CO exposures. However, no significant association was found between birth defects and O3, PM2.5 and NO2 exposures (P > 0.05). Conclusion This study provides a comprehensive description of ethnic differences in BDs in Southwest China and broadens the evidence of the association between air pollution exposure during gestation and BDs.

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“…Zhao et al reported that the effects of air pollutants on birth defects Open access were obvious the warm season in Hohhot. 44 This disparity could be partly explained by the uneven levels of dwellings' air pollutants. Compared with cities with lower GDP, cities with a higher GDP and a large population might have lower concentrations of indoor particulate matter.…”

Section: Discussionmentioning

confidence: 99%

“…After stratified by season, maternal exposure of PM 2.5 , NO 2 and SO 2 were positively associated with birth defects in the cold season instead of the warm season. Zhao et al reported that the effects of air pollutants on birth defects were more obvious in the warm season in Hohhot 44. This disparity could be partly explained by the uneven levels of dwellings’ air pollutants.…”

Section: Discussionmentioning

confidence: 99%

Ambient air pollutants in the first trimester of pregnancy and birth defects: an observational study

Cheng¹,

Yin

Yang³

et al. 2023

BMJ Open

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ObjectivesAs current studies on the relationships between air pollutants exposure during the first trimester and birth defects were not fully elucidated, this study aimed to assess the association between selected air pollutants and birth defects.DesignAn observational study.ParticipantsWe obtained 70 854 singletons with gestational age <20 weeks who were delivered at a large maternal and child healthcare centre in Wuhan, China.Outcome measuresBirth defects data and daily average concentration of ambient particulate matter ≤10 µm diameter (PM10), PM ≤2.5 µm diameter (PM2.5), sulfur dioxide (SO2) and nitrogen dioxide (NO2) were obtained. Logistic regression analysis was applied to assess the association between maternal air pollutants exposure during first trimester and total birth defects, congenital heart defects (CHDs), limb defects and orofacial clefts with adjustments of potential covariates.ResultsThere were a total of 1352 birth defect cases included in this study, with a prevalence of 19.08‰. Maternal exposed to high concentrations of PM10, PM2.5, NO2and SO2in the first trimester were significantly associated with elevated ORs of birth defects (ORs ranged from 1.13 to 1.23). Additionally, for male fetuses, maternal exposed to high PM2.5concentration was associated with an elevated odd of CHDs (OR 1.27, 95% CI 1.06 to 1.52). In the cold season, the ORs of birth defects were significantly increased among women exposed to PM2.5(OR 1.64, 95% CI 1.41 to 1.91), NO2(OR 1.22, 95% CI 1.08 to 1.38) and SO2(OR 1.26, 95% CI 1.07 to 1.47).ConclusionsThis study showed unfavourable effects of air pollutants exposure during the first trimester on birth defects. Especially, the association between maternal PM2.5exposure and CHDs was only observed among male fetuses, and stronger effects of PM2.5, NO2and SO2exposure on birth defects were observed in the cold season.

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Increasing risk of congenital anomalies associated with seasonal pattern of air pollution: Differences by maternal comorbidities

Cited by 8 publications

References 34 publications

The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China

The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China

The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China

Ambient air pollutants in the first trimester of pregnancy and birth defects: an observational study

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