Increasing rate of a positive family history of inflammatory bowel disease (IBD) in pediatric IBD patients

Ruban, Maya; Slavick, Adam; Amir, Achiya; Ben‐Tov, Amir; Moran‐Lev, Hadar; Weintraub, Yael; Anafy, Adi; Cohen, Shlomi; Yerushalmy‐Feler, Anat

doi:10.1007/s00431-021-04269-8

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…This likely reflects the increased recognition of the role of diet in IBD by our patients’ families. Together with a family history rate similar to a cohort of pediatric IBD patients in Israel [ 30 ], our findings raise suspicion for an interaction between lifestyle practices on top of an underlying risk background in the development of IBD in Asian children in the U.S.…”

Section: Discussionsupporting

confidence: 69%

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Clinical and lifestyle patterns in Asian children with inflammatory bowel disease in the U.S.

et al. 2023

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Background While there are many epidemiologic studies of Asian immigrants to the West and risk of inflammatory bowel disease (IBD), the phenotype and lifestyle of Asian patients, particularly children, with IBD are not well described. In this study, we describe lifestyle practices, such as dietary pattern, as well as disease phenotype in Asian American children with IBD. Methods We reviewed the records of children with IBD, ages 0 to 21 years old, and race identified as Asian, Indian, or Pacific Islander. Patients who received outpatient IBD care at our center between January 2013 and January 2020 were included. We excluded patients who were international second opinions, who did not have a definitive diagnosis of IBD, and in whom a diagnosis of IBD was made after 18 years of age. A survey, including a food frequency questionnaire adapted from NHANES DSQ with modifications to include culturally appropriate food elements, was designed and conducted within this cohort to assess for dietary patterns. Results Asian patients in our cohort have similar phenotypes as non-Asians with few distinctive differences. There was a Crohn’s disease and male predominance similar with non-Asians. However, there was a high rate of proctitis in ulcerative colitis in Asian patients. Asian patients reported a typical dietary pattern that reflects a Westernized pattern rather than a traditional pattern. Despite a similar dietary pattern, there was a high rate of 25-OH Vitamin D deficiency (44%) and insufficiency (40%). Conclusions This single center study showed that the phenotype of Asian children with IBD in the U.S. is similar with that of non-Asian with a few distinct differences. The Asian children in our cohort reported following a Westernized dietary pattern and lifestyle. However, there was a high rate of Vitamin D deficiency surrounding diagnosis, suggesting a need for vigilant monitoring.

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Section: Discussionsupporting

confidence: 69%

“…cohort of pediatric IBD patients in Israel [30], our findings raise suspicion for an interaction between lifestyle practices on top of an underlying risk background in the development of IBD in Asian children in the U.S.…”

Section: Plos Onementioning

confidence: 69%

Clinical and lifestyle patterns in Asian children with inflammatory bowel disease in the U.S.

et al. 2023

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“…Current researchers confirm that IBD with a positive family history is associated with a younger age of diagnosis and a more unfavorable disease phenotype [ 117 ]. This is supported by research findings and indicates that the prevalence of a positive family history of IBD in the pediatric population is increasing [ 118 , 119 ]. Children diagnosed between 2016 and 2020 had a higher prevalence of positive family history compared to those diagnosed between 2010 and 2015 (31.8% vs. 20.7%, respectively, p = 0.024) [ 120 ].…”

Section: Etiology—genetics Factorssupporting

confidence: 64%

Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update

Jarmakiewicz-Czaja

Zielińska

Sokal

et al. 2022

Genes

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Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and remission of the disease. The etiology of IBD is not fully understood. Many studies point to the presence of genetic, immunological, environmental, and microbiological factors and the interactions between them in the occurrence of IBD. The review looks at genetic factors in the context of both IBD predisposition and pharmacogenetics.

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Antibiotics, passive smoking, high socioeconomic status and sweetened foods contribute to the risk of paediatric inflammatory bowel disease: A systematic review with meta‐analysis

Thacker,

Duncanson,

Eslick

et al. 2024

J. pediatr. gastroenterol. nutr.

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ObjectiveGenetic and environmental factors influence pathogenesis and rising incidence of paediatric inflammatory bowel disease (PIBD). The aim was to meta‐analyse evidence of diet and environmental factors in PIBD.MethodsA systematic search was conducted to identify diet and environmental factors with comparable risk outcome measures and had been reported in two or more PIBD studies for inclusion in meta‐analyses. Those with ≥2 PIBD risk estimates were combined to provide pooled risk estimates.ResultsOf 4763 studies identified, 36 studies were included. PIBD was associated with higher risk with exposure to ≥/=4 antibiotic courses (includes prescriptions/purchases/courses), passive smoking, not being breastfed, sugary drink intake, being a non‐Caucasian child living in a high‐income country and infection history (odds ratio [OR] range: 2–3.8). Paediatric Crohn's disease (CD) was associated with higher risk with exposure to antibiotics during early childhood, ≥/=4 antibiotic courses, high socioeconomic status (SES), maternal smoking, history of atopic conditions and infection history (OR range: 1.6–4.4). A history of infection was also associated with higher risk of paediatric ulcerative colitis (UC) (OR: 3.73). Having a higher number of siblings (≥2) was associated with lower risk of paediatric CD (OR: 0.6) and paediatric UC (OR: 0.7). Pet exposure was associated with lower risk of paediatric UC (OR: 0.5).ConclusionSeveral factors associated with PIBD risk were identified that could potentially be used to develop a disease screening tool. Future research is needed to address risk reduction in PIBD.

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Increasing rate of a positive family history of inflammatory bowel disease (IBD) in pediatric IBD patients

Cited by 9 publications

References 31 publications

Clinical and lifestyle patterns in Asian children with inflammatory bowel disease in the U.S.

Clinical and lifestyle patterns in Asian children with inflammatory bowel disease in the U.S.

Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update

Antibiotics, passive smoking, high socioeconomic status and sweetened foods contribute to the risk of paediatric inflammatory bowel disease: A systematic review with meta‐analysis

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