Increasing prevalence of hypospadias in Western Australia, 1980-2000

Nassar, Natasha; Bower, Carol; Barker, Andrew

doi:10.1136/adc.2006.112862

Cited by 91 publications

(70 citation statements)

References 25 publications

(12 reference statements)

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“…The present study found that isolated hypospadias is the main type of hypospadias occurring in China, accounting for 84.55% of overall cases, which is similar to the report from Australia (Nassar et al, 2007). The prevalences of overall and isolated hypospadias in China were 9.03 and 7.64 per 10,000 male births, respectively, and lower than in the data reported by other countries or regions.…”

Section: Discussionsupporting

confidence: 81%

“…Currently, the time trends of hypospadias prevalence in other countries worldwide are not consistent. Australia (Nassar et al, 2007), Denmark (Lund et al, 2009), and the United Kingdom (Abdullah et al, 2007a) have reported increasing trends in hypospadias prevalence, whereas Japan (Kurahashi et al, 2004), Scotland (Ahmed et al, 2004), and the U.S. states of New York (Fisch et al, 2009), Washington (Porter et al, 2005), and California (Carmichael et al, 2003) have reported no significant increases. In addition, regional differences in hypospadias prevalences have been reported; for example, a spatial clustering of hypospadias prevalences was found in northern England (Abdullah et al, 2007a).…”

Section: Introductionmentioning

confidence: 93%

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Time trends and geographic variations in the prevalence of hypospadias in China

Mao

Dai

et al. 2011

Birth Defects Research

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 93%

Time trends and geographic variations in the prevalence of hypospadias in China

Mao

Dai

et al. 2011

Birth Defects Research

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“…Hypospadias is one of the most common congenital malformations in males, affecting 1 in 250-300 individuals at birth (Nassar et al, 1997;Ghirri, et al, 2009). The occurrence of hypospadias has been linked to genetic, endocrine, and several environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Androgen receptor gene CAG repeat polymorphism and risk of isolated hypospadias: results from a meta-analysis

et al. 2015

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ABSTRACT. Studies investigating the association between the CAG repeat polymorphism and the risk of isolated hypospadias have reported conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, CNKI, and Wanfang databases. Weighted mean difference and 95% confidence intervals for the CAG repeat polymorphism and isolated hypospadias were calculated using a random-effects model. Subgroup analyses were performed by race, study design, sample for DNA extraction, and hypospadias classifications. This meta-analysis included 6 case-control studies, including 444 isolated hypospadias cases and 727 controls. The results showed that patients with isolated hypospadias had longer CAG repeats in their androgen receptor gene sequence (weighted mean difference = 1.36, 95% confidence interval = 0.60-2.13; P = 0.0005). Similarly, stratified analyses also detected significant associations in all subgroups, excluding the group with severe hypospadias (weighted mean difference = 0.35, 95% confidence interval = -0.42-1.12; P = 0.38). This meta-analysis indicated that longer CAG repeats were 1581 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 1580-1588 (2015 CAG repeat polymorphism and isolated hypospadias associated with the risk of isolated hypospadias, and that longer CAG polymorphisms may be related to the etiology of isolated hypospadias. Future studies based on Asian and African-American patients should be performed to re-evaluate this association.

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“…In the last 30 years there is an increase in the prevalence of hypospadias. [10][11][12][13][14] The aim of hypospadias surgery is to obtain a functional and cosmetically normal penis. More than 300 different techniques have been explained in the treatment of hypospadias.…”

Section: Discussionmentioning

confidence: 99%

Short term outcomes of snodgrass urethroplasty in distal and mid penile hypospadias

Pramod

Anukethan

2018

Int Surg J

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Background: Hypospadias is common congenital condition. First attempted hypospadias surgery was done during first century A.D. Since then more than 300 techniques have been explained in the surgery for Hypospadias. The goal of surgery is focused on functional and cosmetic outcomes. In 1994 Snodgrass popularized the technique of urethral plate incision, tubularization and secondary dorsal healing for hypospadias repair. Aim of the study was to evaluate the short term outcomes of Snodgrass urethroplasty.Methods: This was a retrospective study conducted by the department of Pediatric Surgery, Kempegowda Institute of medical sciences (KIMS) hospital, Bangalore from 2014 to 2017. Children with mid penile and distal hypospadias who had undergone Snodgrass urethroplasty were enrolled in the study. Children with previous surgery were excluded. The demographic data, duration of surgery, post operative requirement of anticholinergics, duration of catheterization and post operative stay were tabulated. Children were followed up for duration of 6 months to 3 years. Post operative complications were tabulated. Results: 40 children were included in the study. Age ranges of children were between 9 months to 14 years. In most of the children hypospadias was diagnosed at birth. The mean duration of surgery was 97.25 minutes. The mean duration of hospitalization was12.2 day. The overall complications rate was 20%. The most common complication was urethrocutaneous fistula. Out of the 40 children included in the study 4(10%) children required resurgery (urethrocutaneous fistula closure).Conclusions: Snodgrass urethroplasty is a simple and effective technique. It is easy to learn and can be applied as a single stage procedure. The most common complications are urethrocutaneous fistula and meatal stenosis.

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Increasing prevalence of hypospadias in Western Australia, 1980-2000

Abstract: Hypospadias affects one in 231 births and has been reported to have increased significantly over the last 20 years. Future investigation of the aetiology of hypospadias is important to identify potentially modifiable risk factors and ensure optimal male reproductive health in the future.

Cited by 91 publications

References 25 publications

Time trends and geographic variations in the prevalence of hypospadias in China

Time trends and geographic variations in the prevalence of hypospadias in China

Androgen receptor gene CAG repeat polymorphism and risk of isolated hypospadias: results from a meta-analysis

Short term outcomes of snodgrass urethroplasty in distal and mid penile hypospadias

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