Increasing Incidence of Testicular Cancer Worldwide: A Review

Huyghe, É.; Matsuda, Tomohiro; Thonneau, Patrick

doi:10.1097/01.ju.0000053866.68623.da

Cited by 540 publications

(348 citation statements)

References 34 publications

Supporting

Mentioning

323

Contrasting

Unclassified

Order By: Relevance

“…The incidence of testicular germ cell tumours (TGCTs) has increased markedly during the past decades, and although accounting for only 1 -2% of all cancers in men, TGCTs are now the most common malignancy in the age group of 15 -35 years old men (Adami et al, 1994;Huyghe et al, 2003). Owing to a refined treatment, in particular the introduction of cisplatin in combination chemotherapy, mortality rates have declined rapidly (Einhorn, 1981;Schmoll et al, 2004).…”

mentioning

confidence: 99%

Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours

et al. 2005

View full text Add to dashboard Cite

The carcinoma in situ (CIS) cell is the common precursor of nearly all testicular germ cell tumours (TGCT). In a previous study, we examined the gene expression profile of CIS cells and found many features common to embryonic stem cells indicating that initiation of neoplastic transformation into CIS occurs early during foetal life. Progression into an overt tumour, however, typically first happens after puberty, where CIS cells transform into either a seminoma (SEM) or a nonseminoma (N-SEM). Here, we have compared the genome-wide gene expression of CIS cells to that of testicular SEM and a sample containing a mixture of N-SEM components, and analyse the data together with the previously published data on CIS. Genes showing expression in the SEM or N-SEM were selected, in order to identify gene expression markers associated with the progression of CIS cells. The identified markers were verified by reverse transcriptase -polymerase chain reaction and in situ hybridisation in a range of different TGCT samples. Verification showed some interpatient variation, but combined analysis of a range of the identified markers may discriminate TGCT samples as SEMs or NSEMs. Of particular interest, we found that both DNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) and DNMT3L (DNA (cytosine-5-)-methyltransferase 3 like) were overexpressed in the N-SEMs, indicating the epigenetic differences between N-SEMs and classical SEM.

show abstract

mentioning

confidence: 99%

Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Rather, testicular cancer does seem to be showing a genuine increase in incidence in the last 30 years in most industrialized countries in North America, Europe and Oceania. 17 Notwithstanding significant differences in absolute incidence between countries, this increase is occurring at a rate that would be consistent with an environmental, rather than a genetic, cause. The inflection point for the recent rise in testicular cancer levels coincides with the end of World War II, which, in turn, is linked to a massive expansion in the chemicals industry.…”

Section: Environmental Factorsmentioning

confidence: 95%

Falling sperm counts twenty years on: where are we now?

Aitken¹

2013

Asian J Androl

View full text Add to dashboard Cite

“…Familial clustering of testicular cancer [3][4][5][6][7] and the occurrence of bilateral tumors [8][9][10][11] seem to be good argu- Keywords: testicular cancer; familial cancer risk; childhood tumors ments in favor of an influence of genetic factors. Common environment of family members, 12 endogenous and exogenous sources of exposure, [8][9][10][11][12][13] and increased worldwide incidence of the disease 1,14 suggest the importance of environmental factors. Socio-economic status, which is determined mainly by occupations in this part of Europe, may further modify the life styles, dietary habits, and reproductive practices of testicular tumor patients (TTPs) and their family members.…”

Section: Introductionmentioning

confidence: 99%