Increased predisposition to cancer in brothers and offspring of testicular tumor patients

Gundy, Sarolta; Babosa, Mária; Baki, M.; Bodrogi, I.

doi:10.1007/bf03033760

Cited by 31 publications

(25 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conformity with my hypothesis, men destined to suffer this disease reportedly sire a disproportionate number of sons (James, 1990).Testicular cancer also obviously has endocrine determinants : patients reportedly have a low testosterone/gonadotrophin ratio (Petersen et al, 1999), and there are grounds for suspecting that this endocrine profile directly (at least partially) causes this cancer. In conformity with my hypothesis, men who are destined to suffer the disease (and men who already have it) reportedly sire significant excesses of daughters (Moller, 1998;Jacobsen et al, 2000;Gundy et al, 2004). (4) Female endocrine disease (Polycystic ovarian syndrome PCOS): The principal endocrine component of this syndrome is excess androgen secretion.…”

Section: Article In Pressmentioning

confidence: 55%

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

James

2006

Journal of Theoretical Biology

View full text Add to dashboard Cite

Section: Article In Pressmentioning

confidence: 55%

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

James

2006

Journal of Theoretical Biology

View full text Add to dashboard Cite

“…First-degree relatives were observed to have increased risks of female genital organ, hematopoetic, and non-melanoma skin cancer, and a decreased risk of head and neck cancer. Associations for female genital cancer have also been inconsistent, with three studies reporting increased risks,5, 8, 11 and 4 studies reporting no association 3, 9, 15, 19. Risk associated with hematopoetic cancers have been inconsistent, with one study reporting an increased risk in mothers,9 one reporting decreased risk,3 and others finding no association 6, 15, 19.…”

Section: Discussionmentioning

confidence: 99%

“…Associations for female genital cancer have also been inconsistent, with three studies reporting increased risks,5, 8, 11 and 4 studies reporting no association 3, 9, 15, 19. Risk associated with hematopoetic cancers have been inconsistent, with one study reporting an increased risk in mothers,9 one reporting decreased risk,3 and others finding no association 6, 15, 19. No studies have previously observed an association with non-melanoma skin cancer,3, 9 although two studies have reported an increased risk of melanoma 3, 9.…”

Section: Discussionmentioning

confidence: 99%

Risk of cancer in first‐ and second‐degree relatives of testicular germ cell tumor cases and controls

Chia

Goldin

et al. 2008

Intl Journal of Cancer

View full text Add to dashboard Cite

Risk factors for testicular germ cell tumors (TGCT) have not been well identified; however, data suggest that risks of cancer in family members of men with TGCT is elevated. Using family history data from 738 cases and 904 controls enrolled in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) Study from 2002 to 2005, the risk of cancer in first-and second-degree family members of these men was examined. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for reference age of case or control, race/ethnicity of case or control, sex of family member and lineage (maternal vs. paternal). An increased risk of all cancer among first-degree relatives of cases compared to controls was observed (RR 5 1.17, 95% CI: 1.01-1.35). There were suggestions of differences in risk when stratifying all relatives by lineage. For maternal relatives, there was a statistically significant increased risk of all cancer (RR 5 1.16, 95% CI: 1.04-1.30), digestive tract (RR 5 1.52, 95% CI: 1.15-2.00) and male genital organ cancer (RR 5 1.70, 95% CI: 1.15-2.51); there was also a suggestion of increased risks of hematopoetic cancers, cancers in the female genital organs and nonmelanoma skin cancer. For paternal relatives, there was a statistically significant association only with decreased risk of lung cancer (RR 5 0.69, 95% CI: 0.51-0.94). Thus, this study suggests that there may be aggregation of cancer among families of men diagnosed with TGCT. Published 2008 Wiley-Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.Key words: testicular cancer; family; aggregation Testicular germ cell tumors (TGCT) are the most common tumors among men in the U.S. aged 15-35 years, and the incidence of certain subtypes is still rising. 1 However, with the exception of cryptorchidism, which has been shown to increase risk substantially, other risk factors for TGCT have not been well identified, 2 although there is some evidence that a genetic predisposition to TGCT may exist. Several studies have shown that men with TGCT, compared to those without, are more likely to have a family member also affected with TGCT. Brothers of cases have been shown to have a 5-to 14-fold increase in risk of having TGCT, [3][4][5][6] and this elevated risk is particularly evident among twins. 7 Fathers of men with TGCT have also been shown to have elevated risk of having TGCT, although the increase in risk is not as high, ranging from 1.75 to 4.50. 3,4,6,[8][9][10] Other studies have indicated an elevated risk of other cancers among first-and second-degree family members, including a higher risk of breast cancer 8,9,11-14 and cancer in the female genital organs of mothers or sisters of TGCT cases. 9,11 Thus, it is reasonable to posit that there may be an increased risk of hormonally related cancers among family members of men with TGCT.There have been several studies on aggregation of cancer among families ide...

show abstract

“…These studies underscore the fact that epidemiological associations between testicular cancer risk and environmental factors continue to evolve. Clear-cut associations, on the other hand, have been well established for known factors like cryptorchidism, infertility, and family history, with recent studies further confirming this [8]. Interestingly, low activity of the cytochrome P450 enzyme CYP1A2, which can metabolize many procarcinogens, may be associated with enhanced TGCT risk [9].…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 80%

Germ cell tumors

Hussain¹

2005

Current Opinion in Oncology

View full text Add to dashboard Cite

show abstract

Increased predisposition to cancer in brothers and offspring of testicular tumor patients

Cited by 31 publications

References 30 publications

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

Possible constraints on adaptive variation in sex ratio at birth in humans and other primates

Risk of cancer in first‐ and second‐degree relatives of testicular germ cell tumor cases and controls

Germ cell tumors

Contact Info

Product

Resources

About