Increasing Incidence of Hepatitis A in Korean Adults

Kim, Yoon Jun; Lee, Hyo‐Suk

doi:10.1159/000252778

Cited by 48 publications

(34 citation statements)

References 59 publications

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“…[14] Previous sero-epidemiological studies in India and in other developing countries such as Bangladesh, Bhutan and Nepal also demonstrated that 85-95% of children have been infected with the HAV infection and are immune to HAV infection by their 10 years of age. [14] However, recent studies have noticed a shift of HAV infection from child to adult[15] and there had a progress of safe water and sanitation comparatively. In the present study, the HAV infection is 24.41% in <19 years; majority of cases 60.85% were in 20-39 years; 11.62% in 40-59 years, 3.1% in 60-79 years and none of the cases has reported in the 80 years and above.…”

Section: Discussionmentioning

confidence: 99%

“…Not only the Indian studies but the studies from all over the world also pointing the fact that along with the socio-economic improvement, infection of HAV cases increasing in the adult compared to childhood. [20] The studies reports from Korea,[15] Indonesia, Thailand, China,[21] Sri Lanka and Malaysia[22] also reports that the infection level increasing as per age increases.…”

Section: Discussionmentioning

confidence: 99%

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A hospital-based retrospective study on frequency and distribution of viral Hepatitis

Antony¹,

Celine²

2014

J Global Infect Dis

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Background:Viral hepatitis is a major public health problem throughout the world. It is the inflammation of the liver due to the infection of any of the five main hepatic viruses A to E and it affects the liver through different modes of transmission. This study mainly aims at the frequency and distribution of viral hepatitis based on age and sex during a time period of 5 years.Materials and Methods:This is a hospital-based retrospective study of 5 years at a tertiary level hospital in Kerala state in India. Medical records department of the hospital follow the guidelines of International Classification of Diseases-10 for coding the diseases. The data on frequency and distribution of viral hepatitis based on age and sex during a period of 5 years from April 2005 to March 2010 were collected and analyzed and ‘z’ test was used for finding out the difference in proportions.Result:Out of 818 cases, 76.03% were males and 23.96% were females. The preponderance of males was apparent in all types of viral hepatitis infection. The high risk groups were the adults in the age group of 20-39 years. The main cause in the present study was hepatitis E virus (HEV) and followed by hepatitis A virus (HAV). Of total viral hepatitis cases, 31.54% were due to HAV, 6.35% hepatitis B virus, 0.85% hepatitis C virus and 61.24% were due to HEV respectively. In the present study, there was no case of hepatitis D virus has reported. The case fatality rate of viral hepatitis in the present study was minor than 1% (0.98%); whereas males were 0.96%; females of 1.02%.Conclusion:Taking the safety measures including vaccination and proper management of waste materials are the only solution to control or eradicate this infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A hospital-based retrospective study on frequency and distribution of viral Hepatitis

Antony¹,

Celine²

2014

J Global Infect Dis

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“…The number of cases of hepatitis A reported to Korea Centers for Disease Control and Prevention increased sharply from 798, 2,081 and 2,233 in 2005, 2006 and 2007, respectively to 7,895 and 15,231 in 2008 and 2009, respectively 2. These are data from surveillance reporting system, while the numbers of claims actually made to National Health Insurance Cooperation are at least 3-4 times higher than them.…”

Section: Introductionmentioning

confidence: 90%

A nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates

Lee¹,

Lee

et al. 2011

Korean J Hepatol

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Background/AimsRecent outbreak of hepatitis A in Korea is clearly related to the epidemiological shift of hepatitis A virus (HAV). However, nationwide seroprevalence data have been limited. This study estimated the nationwide, age- and area-adjusted anti-HAV prevalence from 2005 to 2009.MethodsRetrospective analysis of the results of total anti-HAV test in 25,140 cases which were requested by 1,699 medical institutions throughout the nation to Seoul Clinical Laboratory from Jan. 1 2005 to Dec. 31 2009 was performed. The estimated seroprevalence was adjusted by area and age of the standard population based on the 2005 Census data from Korea National Statistical Office.ResultsThe area-adjusted anti-HAV prevalence in the children younger than 10 years were 33.4% in 2005 and 69.9% in 2009. The most susceptible age groups to HAV infection during the last 5 years were teenagers and the young adults in their age of twenties. The area-adjusted seroprevalence in 2009 were 11.9% in the age group of 20-29 years, 23.4% in the age group of 10-19 years, 48.4% in the age group of 30-39 years. The population in 40-49 years showed geographically different seroprevalence with the lowest rate in Seoul (80%).ConclusionsThe most susceptible age group to HAV infection is 10-29 years, while the young children less than 10 years showed about 70% seropositivity. The changing seroepidemiology should be monitored continuously for the proper vaccination and patient care.

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“…[6][7][8] During the past decades, public hygiene and the environmental conditions have improved in Korea, as a result, an epidemiological shift in HAV seroprevalence has occurred. [9][10][11][12][13] Individuals that had HAV infection generally acquire lifelong immunity to all strains of HAV; the seroprevalence of HAV might reflect subclinical infection with HAV. In this study, we investigated the seroprevalence of HAV and associated socioeconomic factors for HAV seropositivity in young healthy Korean adults.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hepatitis A and Associated Socioeconomic Factors in Young Healthy Korean Adults

Chung¹,

Yim²,

Kim³

et al. 2011

Gut Liver

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Background/Aims: An epidemiologic shift of hepatitis A virus (HAV) seroprevalence is expected due to an improvement in socioeconomic status in young adults in Korea. We investigated the age-specific seroprevalence and socioeconomic factors associated with HAV seropositivity in young, healthy Korean adults. Methods: Between March 2009 and February 2010, a total of 5,051 persons from 20 to 49 years of age presenting for a health check-up were included and responded to a questionaire. The seroprevalence of HAV was investigated by measuring immunoglobulin G (IgG) anti-HAV. A total of 984 pairs of cases and age-and sex-matched controls were analyzed for associated socioeconomic factors. Results: The prevalence of seropositive HAV was 6.2% in the 20 to 29 age range, 33.1% in the 30 to 39 range and 82.4% in the 40 to 49 range (p<0.001). There were no signifi cant differences in any group according to gender. A multivariate analysis for paired cases indicated that HAV seropositivity was signifi cantly higher in the low monthly income (below fi ve million won, approximately 4,300 dollars) group and the Helicobacter pylori (H. pylori)-positive group (odds ratio [OR], 1.65; 95% confi dence interval [CI], p<0.001; OR, 1.45; 95% CI, p<0.001, respectively). Conclusions: HAV seropositivity in young adults presenting for a health checkup appears to be decreasing, and the prevalence was signifi cantly higher in the low monthly income group and the H. pylori-positive group. (Gut Liver 2011;5:88-92)

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Increasing Incidence of Hepatitis A in Korean Adults

Cited by 48 publications

References 59 publications

A hospital-based retrospective study on frequency and distribution of viral Hepatitis

A hospital-based retrospective study on frequency and distribution of viral Hepatitis

A nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates

Seroprevalence of Hepatitis A and Associated Socioeconomic Factors in Young Healthy Korean Adults

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