Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: A 20-year renal biopsy study

Haas, Mark; Spargo, Benjamin H.; Coventry, Susan

doi:10.1016/0272-6386(95)90437-9

Cited by 197 publications

(153 citation statements)

References 11 publications

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“…Even though these studies showed an increasing incidence of FSGS in white as well as black adults, clearly the findings were more impressive for the black population, and collapsing GN (seen most often in black patients) constituted up to 4.7% of all patients with FSGS. Furthermore, they included referral cases from metropolitan areas with different racial backgrounds (3,4,8). This may restrict extension of these observations to the general population of the United States, which is predominantly white.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent studies, mostly from Europe and Australia, have suggested a change in the pattern of glomerular diseases in the community: According to these, focal segmental glomerulosclerosis (FSGS) is increasing in incidence and now accounts for 20 to 25% of all adult NS cases (1)(2)(3). Furthermore, a recent study from the United States has shown FSGS to be the most common idiopathic glomerular disease in adults (4).…”

mentioning

confidence: 99%

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Changing Incidence of Glomerular Disease in Olmsted County, Minnesota

Swaminathan¹,

Leung²,

Lager³

et al. 2006

Clinical Journal of the American Society of Nephrology

226

185

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Changing Incidence of Glomerular Disease in Olmsted County, Minnesota

Swaminathan¹,

Leung²,

Lager³

et al. 2006

Clinical Journal of the American Society of Nephrology

226

185

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“…Focal segmental glomerulosclerosis (FSGS), first described by Rich in 1957 [1], is currently recognized as one of the most common causes of primary glomerular diseases in adults and its incidence has recently been increasing [2]. FSGS causes asymptomatic proteinuria or nephrotic syndrome (NS) with or without any renal insufficiency.…”

Section: Introduction: Overview Of Animal Models For Focal Segmental mentioning

confidence: 99%

Recent advances of animal model of focal segmental glomerulosclerosis

Yang

Dettmar

Kronbichler³

et al. 2018

Clin Exp Nephrol

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In the last decade, great advances have been made in understanding the genetic basis for focal segmental glomerulosclerosis (FSGS). Animal models using specific gene disruption of the slit diaphragm and cytoskeleton of the foot process mirror the etiology of the human disease. Many animal models have been developed to understand the complex pathophysiology of FSGS. Therefore, we need to know the usefulness and exact methodology of creating animal models. Here, we review classic animal models and newly developed genetic animal models. Classic animal models of FSGS involve direct podocyte injury and indirect podocyte injury due to adaptive responses. However, the phenotype depends on the animal background. Renal ablation and direct podocyte toxin (PAN, adriamycin) models are leading animal models for FSGS, which have some limitations depending on mice background. A second group of animal models were developed using combinations of genetic mutation and toxin, such as NEP25, diphtheria toxin, and Thy1.1 models, which specifically injure podocytes. A third group of animal models involves genetic engineering techniques targeting podocyte expression molecules, such as podocin, CD2-associated protein, and TRPC6 channels. More detailed information about podocytopathy and FSGS can be expected in the coming decade. Different animal models should be used to study FSGS depending on the specific aim and sometimes should be used in combination.

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“…According to several authors, the worldwide incidence of FSGS is on the rise annually, including in Brazilian statistics (1,8,9) . Data from the Paulista registry of glomerulopathies shows that FSGS is the most common primary glomerulopathy in 11 centers of São Paulo, accounting for 29.7% of cases, followed by membranous nephropathy (20.7%) and immunoglobulin A (IgA) nephropathy (17.8%) (12) .…”

Section: Introductionmentioning

confidence: 99%