2018
DOI: 10.1007/s10157-018-1552-8
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Recent advances of animal model of focal segmental glomerulosclerosis

Abstract: In the last decade, great advances have been made in understanding the genetic basis for focal segmental glomerulosclerosis (FSGS). Animal models using specific gene disruption of the slit diaphragm and cytoskeleton of the foot process mirror the etiology of the human disease. Many animal models have been developed to understand the complex pathophysiology of FSGS. Therefore, we need to know the usefulness and exact methodology of creating animal models. Here, we review classic animal models and newly develope… Show more

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Cited by 29 publications
(27 citation statements)
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References 86 publications
(111 reference statements)
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“…Thy1 nephritis is a useful mechanistic tool for understanding the processes involved in MC injury and proliferative response in vivo, but it is far from analogous to the human diseases that we seek to modify, such as IgA nephropathy. Acute Thy1 nephritis is largely selflimiting with the injury resolving over 3-4 weeks [6]. More relevant is the development of chronic mesangial proliferative disease models using anti-Thy1 antibody injection after rat unilateral nephrectomy [7].…”
Section: Introductionmentioning
confidence: 99%
“…Thy1 nephritis is a useful mechanistic tool for understanding the processes involved in MC injury and proliferative response in vivo, but it is far from analogous to the human diseases that we seek to modify, such as IgA nephropathy. Acute Thy1 nephritis is largely selflimiting with the injury resolving over 3-4 weeks [6]. More relevant is the development of chronic mesangial proliferative disease models using anti-Thy1 antibody injection after rat unilateral nephrectomy [7].…”
Section: Introductionmentioning
confidence: 99%
“…Classical animal models for FSGS rely on either direct or indirect induction of podocyte injury through the use of renal ablation, podocyte-specific toxins (adriamycin, puromycin aminonucleoside), or targeted genetic mutations (NEP25, diphtheria toxin [DT] receptor, or Thy-1.1 transgenic models). 3 As an example, the transgenic mouse strain NEP25 has been engineered to express the human CD25 receptor exclusively on podocytes. LMB2 is an immunotoxin that selectively targets human CD25.…”
Section: Podocyte Injury Is the Initial Target In Fsgsmentioning
confidence: 99%
“…Often, the genes that are manipulated in these models (e.g., ACTN4 , NPHS2, WT1, CD2AP ) have been identified by familial genetic studies as potentially playing a role in FSGS pathophysiology. 3…”
Section: Podocyte Injury Is the Initial Target In Fsgsmentioning
confidence: 99%
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“…In order to induce glomerular injury in animal models, adriamycin (ADR or Doxorubicin) is widely used. ADR is an anthracycline that is commonly utilized to induce FSGS in rodents [11][12][13]. The efficacy of ADR is strongly dependent on the rodent strain it is used on.…”
Section: Introductionmentioning
confidence: 99%