There are broad effects of vegetation changes on regional climate, carbon budget, the water cycle, and ecosystems’ productivity. Therefore, further knowledge of the drivers of future vegetation changes is critical to mitigate the influences of global warming. The El Niño–Southern Oscillation (ENSO) is a major mode of interannual climate variability and is likely to affect vegetation on the global scale. Nonetheless, little is known about the causal impacts of ENSO on future vegetation cover with changes in land use and a warming environment. Here, we examined the connections between ENSO and vegetation using leaf area index (LAI) data over the period 2015–2100 from Coupled Modeling Intercomparison Project Phase 6. Our findings indicate that, compared with the historical period 1915–2000, the vegetated areas influenced by ENSO are projected to rise by approximately 55.2% and 20.7% during the twenty-first century of the scenarios SSP2-4.5 and SSP5-8.5, respectively. Though uncertainty for the causal link between ENSO and vegetation changes remains in several regions (i.e., parts of North America, southern Australia, and western Asia), ENSO signature on LAI variations is robust over northern Australia, Amazonia, and parts of Southeast Asia. These results indicate that the influences of ENSO on global vegetation may strengthen in the future.