Increasing Burden of Infective Endocarditis in Saskatoon Health Region

Staphylococcus lugdunensis Endocarditis: Lower Mortality in the Contemporary Era?

“…Our clinical review of 8 cases of S. lugdunensis endocarditis demonstrated an in-hospital mortality of 12.5% compared to 21% in our general IE population and published literature. 3,16,17 These 8 cases represented 1.3% of our total number of admitted endocarditis cases over the same time frame. 3 Furthermore, among definite cases, 16.7% (1/6) of patients had infected prosthetic valves.…”

“…3,16,17 These 8 cases represented 1.3% of our total number of admitted endocarditis cases over the same time frame. 3 Furthermore, among definite cases, 16.7% (1/6) of patients had infected prosthetic valves. Both of the surgically managed patients had large vegetations (>20mm) and successful valve replacements.…”

“…1,2 In Saskatchewan, our incidence of IE cases in general and corresponding hospital admissions, has linearly increased over the last 10 years which is outpacing population growth. 3 This is of particular concern as IE is associated with high inhospital mortality and prolonged hospital stays. 3 Moreover, Skinner et al (2018) describe a rise in Hepatitis C and HIV infection in Canada which is disproportionately affecting Saskatchewan due to high levels of injection drug use and marginalized populations with poor access to health care.…”

“…3 This is of particular concern as IE is associated with high inhospital mortality and prolonged hospital stays. 3 Moreover, Skinner et al (2018) describe a rise in Hepatitis C and HIV infection in Canada which is disproportionately affecting Saskatchewan due to high levels of injection drug use and marginalized populations with poor access to health care. 4 This combination of findings, coupled with the known fact that Hepatitis C and HIV coinfection in IE leads to poorer prognosis 5 , led us to question whether our S. lugdunensis IE population had unique clinical characteristics compared to previous reviews.…”

“… 1 , 2 In Saskatchewan, our incidence of IE cases in general, and corresponding hospital admissions, has increased linearly over the past 10 years, outpacing population growth. 3 This trend is of particular concern, as IE is associated with high in-hospital mortality and prolonged hospital stays. 3 Moreover, Skinner et al.…”