Staphylococcus lugdunensis Endocarditis: Lower Mortality in the Contemporary Era?

Abstract

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Clinical Disease and Outcomes of Invasive Staphylococcus lugdunensis Infection in a University Hospital in Saudi Arabia

“…In more recent studies, the mortality due to infective endocarditis, regardless of the pathogen involved, was estimated to be 20% to 28% [28,29]. Only one recent study specifically reported S. lugdunensis-related infective endocarditis mortality, which was also low at 12.5% [30]. However, none of our patients had infective endocarditis.…”

Clinical and microbiological characteristics of Staphylococcus lugdunensis

“…Overall mortality for S. lugdunensis IE is approximately 40% [3,15,32] and up to 78% in the subset of patients with prosthetic valve IE, which is considerably higher than the mortality reported for other CoNS (16-19%) [34,35]. A more recent study suggests the mortality rate may be lower in the contemporary era reporting an in-hospital mortality of 12.5%, however this study was limited by its small sample size of just eight patients [36].…”

Infective Endocarditis Caused by <i>Staphylococcus lugdunensis</i>

“…In multivariate analyses, periannular abscess formation and younger age defined as <50 years were found to be independent prognostic factors for the need for surgery in patients with left-sided IE caused by S. lugdunensis (10). Surgery was required in 20.3% of 310 patients with IE caused by S. aureus, in 60.0% of 75 patients with IE caused by S. epidermidis, and in 70.0% of 10 patients with IE caused by S. lugdunensis; the mortality rates were 7.1%, 20.0%, and 50.0%, respectively (10), although lower mortality was reported more recently (13). S. lugdunensis is reported to lack a specific pattern of susceptibility to antibiotics, with most strains showing susceptibility to penicillin and methicillin, although the choice of antibiotics needs to depend on the results of antibiotic susceptibility tests (10).…”