Increased urinary zinc excretion in cancer patients is linked to immune activation and renal tubular cell dysfunction

Melichar, Bohuslav; Malíř, František; Jandı́k, P; Malířová, Eva; Vávrová, Jaroslava; Mergancová, J; Voboril, Z

doi:10.1007/bf00143377

Cited by 12 publications

(7 citation statements)

References 15 publications

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“…[22] Increased urinary zinc excretion in cancer patients may be linked to immune activation and renal-tubular-cell dysfunction and skeletal-muscle catabolism. [23]…”

Section: Discussionmentioning

confidence: 99%

Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma

et al. 2011

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Objectives:The exact cause of benign prostatic hyperplasia (BPH) and prostatic carcinoma is unknown. Changes in the level of the trace element zinc (Zn) are known to be associated with the functioning of different organs (breast, colon, stomach, liver, kidney, prostate, and muscle). This study is aimed at estimating and comparing the zinc levels in the prostate tissue, plasma, and urine obtained from patients diagnosed with BPH or prostatic carcinoma.Materials and Methods:The prostate tissue zinc, plasma zinc, and urine zinc/creatinine ratio in BPH, prostate cancer, and normal subjects were measured by atomic absorption spectrophotometry.Results:In prostate carcinoma, the mean tissue zinc was decreased by 83% as compared to normal tissue and in BPH, there was a 61% decrease in mean tissue zinc as compared to normal tissues. Both these values were statistically significant. The plasma zinc in prostate cancer patients showed a 27% decrease (P < 0.01) as compared to controls and 18% decrease (P < 0.01) as compared to BPH. The urine zinc/creatinine (ratio) was significantly increased to 53% in prostate cancer patients, and a 20% significant increase was observed in BPH as compared to normal subjects.Conclusions:It is evident from this study that BPH or prostate carcinoma may be associated with a reduction in the levels of tissue zinc, plasma zinc, and an increase in urine zinc/creatinine.

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“…[22] Increased urinary zinc excretion in cancer patients may be linked to immune activation and renal-tubular-cell dysfunction and skeletal-muscle catabolism. [23]…”

Section: Discussionmentioning

confidence: 99%

Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma

et al. 2011

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“…25 Recent data suggest that inflammatory diseases may adversely affect renal tubular zinc transport. 26,27 Therefore, reduction in hepatic inflammation after OLT might lead to normalization of renal zinc excretion.…”

Section: Discussionmentioning

confidence: 99%

Correction of hypozincemia following liver transplantation in children is associated with reduced urinary zinc loss

et al. 1999

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Zinc deficiency is a relatively common problem in children with chronic liver disease. We have previously shown inappropriate urinary zinc excretion in children with chronic liver disease and hypozincemia. This study was designed to determine if zinc deficiency and inappropriate urinary zinc losses are corrected in children with liver disease by liver transplantation. Thirty-three patients (age 1-19 years) underwent 35 liver transplants for acute and chronic liver disease. At the time of transplant, 17 patients had low plasma zinc (hypozincemic) (plasma zinc, 45.4 ؎ 1.8 g/dL), whereas 18 had normal plasma zinc (75.7 ؎ 3.8). Before transplant, patients with zinc deficiency had higher urinary zinc to creatinine ratio compared with those with normal zinc status (6.6 ؎ 1.9 vs. 2.2 ؎ 0.6; P ‫؍‬ .03) and lower serum albumin concentrations (low: 2.8 ؎ 0.1 vs. normal: 3.3 ؎ 0.2; P ‫؍‬ .02). After transplant, there was a significant reduction in urinary zinc losses in the hypozincemic group followed by normalization of plasma zinc levels by 7 days posttransplant. These data suggest that the abnormal renal zinc homeostasis that is present in approximately 50% of pediatric patients undergoing liver transplant is rapidly improved and biochemical zinc deficiency is reversed after liver transplantation. (HEPATOLOGY 1999;29:830-833.)

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“…Increased urinary zinc excretion in cancer patients exhibited a strong correlation with urinary activity of N ‐acetyl‐β‐d‐glucosaminidase (128) , an indicator of renal tubular cell dysfunction (129) . Moreover, a correlation was observed between serum neopterin and both urinary zinc and N ‐acetyl‐β‐d‐glucosaminidase in cancer patients (127) .…”

Section: Chronic Immune Stimulation and Immune Deficiencymentioning

confidence: 92%

“…Association between increased neopterin production, trace element metabolism, and immune response in cancer patients Urinary zinc excretion is increased and serum zinc concentrations are decreased in cancer patients (125)(126)(127)(128) . Serum zinc levels are of importance for immune response, and the decrease in serum zinc levels was demonstrated to lead to impaired responsiveness of peripheral blood lymphocytes (125) .…”

Section: Increased Neopterin Production and Alterations In Leukocyte mentioning

confidence: 99%

Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies

Melichar

Solichová

Freedman

2006

Int J Gynecol Cancer

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Malignant tumors may contribute to host response that involves both the adaptive and innate immune systems. Among other biochemical indicators of systemic immune and inflammatory activity, activation of macrophages by interferon-gamma induces a marked increase in the production of neopterin. Neopterin production by activated macrophages is also associated with tryptophan degradation. In addition to tumors of other primary locations, increased urinary and serum neopterin concentrations have been reported in patients with gynecological cancers, including epithelial ovarian carcinoma, cervical carcinoma, endometrial carcinoma, uterine sarcomas, and vulvar carcinoma, but not in women with benign neoplasms or precancerous disorders. Increased neopterin concentrations have been associated with poor prognosis. Elevated levels of neopterin have also been observed in the tumor microenvironment. Systemic (urinary or serum) or local (ascitic fluid) neopterin concentrations increased after therapeutic administration of cytokines. Elevated neopterin concentrations have been associated with anemia of chronic disease and increased urinary zinc loss in patients with gynecological malignancy. Elevated neopterin has also been connected with depressed function of peripheral blood lymphocytes and a decrease in CD4+ T-cell numbers.

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Increased urinary zinc excretion in cancer patients is linked to immune activation and renal tubular cell dysfunction

Cited by 12 publications

References 15 publications

Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma

Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma

Correction of hypozincemia following liver transplantation in children is associated with reduced urinary zinc loss

Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies

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