Increased Urinary C-Peptide and Albumin Excretion in Juvenile Borderline Hypertensives

Abstract

The study was designed to evaluate the urinary excretion of C-peptide and albumin, and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in juvenile borderline hypertensives. The second aim was to examine the relationship between these variables and ambulatory blood pressure level and variability. The study group consisted of 21 non-obese males consecutively chosen from patients with borderline hypertension, defined by sphygmanometer readings, examined in our outpatient clinic. All subjects collected separately their day-time and night-time urines during the period of ambulatory blood pressure monitoring. In 16 patients, who were considered to have "sustained" borderline hypertension, both 24-h urinary C-peptide excretion and 24-h UAE were significantly increased in comparison to those of the controls, while NAG activity did not differ significantly between the two groups. UAE was significantly lower at night than during the day in both borderline hypertensives and controls. Twenty-four-hour UAE in borderline hypertensives correlated significantly with the ambulatory blood pressure variability, but not with the average blood pressure level. These results suggest that the 24-h insulin secretion rate estimated by means of urinary C-peptide excretion is significantly increased in "sustained" borderline hypertensives. Elevated UAE in juvenile borderline hypertensives can be explained by a possible direct effect of systemic blood pressure variability on albuminuria.

The influence of exercise on albumin excretion rate in borderline hypertensives and in offspring of hypertensive parents

“…Increased UAE has been reported in people with altered circadian pattern of BP (non-dippers). 34 In studies the correlation was observed only in healthy people 16 or only in hypertensives. 27 The relation this study only a few persons could be classified as non-dippers.…”

“…Similar to index of cardiovascular risk remains to be answered. Reports concerning the possible relationships the results of another study, 16 UAE during the night constituted only a third of 24 h-UAE. Lower UAE between albuminuria and other cardiovascular risk factors are few and inconsistent.…”

“…This notion examined the relations between 24 h-UAE and BP, and a positive correlation between 24 h-UAE and is supported by the fact that in most, 10,[30][31][32] however not in all studies, 14,33 albuminuria correlated with office BP and 24-h ABPM has generally been reported. 10,16,27,31,32,39 However in some of these BP. Increased UAE has been reported in people with altered circadian pattern of BP (non-dippers).…”

“…However, there were no differences between There have been only three studies addressing 24 h-UAE in BH. 11,16,27 Mean 24 h-UAE in these these subgroups in 24 h-ABPM and LVMI. Thus, whether increased ex-UAE may be a very early studies ranged from 5-30 g/min.…”

“…In studies of diabetic individuals MA is derline hypertension. 11,16 A potentially important usually described as an albumin excretion of 30-issue is the influence of physical exercise on albumi-300 mg/24 h. 2 Diabetic individuals with an albumin nuria. In healthy people vigorous exercise can excretion rate exceeding 30 mg/24 h (ie, 20 g/min)…”