The influence of exercise on albumin excretion rate in borderline hypertensives and in offspring of hypertensive parents

Purzycki, Z; Wyrzykowski, Bogdan; Gockowski, K; Winnicki, MM; Kazmirowicz, Mariusz; Krupa-Wojciechowska, B; Sowers, J. R.

doi:10.1038/sj.jhh.1000388

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…11 In nonhypertensive offspring of parents with HTN, urinary albumin excretion has been found to be increased in some 18 but not in other studies. 19 In the present analyses, UACR measured in a spot urine was not related to the parental HTN status. This finding does not exclude the possibility that UACR may be a valuable marker of HTN risk.…”

Section: Crp and Htnmentioning

confidence: 58%

Association of Parental Hypertension With Concentrations of Select Biomarkers in Nonhypertensive Offspring

et al. 2008

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Abstract-Children of parents with hypertension are at increased risk of developing high blood pressure. We hypothesize that circulating concentrations of putative biomarkers (that may play a role in development of high blood pressure) are higher in nonhypertensive offspring of parents with hypertension. We compared concentrations of 4 different biomarkers (urinary albumin:creatinine ratio, circulating C-reactive protein, aldosterone:renin ratio, and plasminogen activator inhibitor-1) in nonhypertensive Framingham offspring study participants with none (nϭ233), 1 (nϭ474), or both (nϭ322) parents with hypertension. Parental hypertension was defined as onset before age 60 years, based on longitudinal observations of the original Framingham cohort. Serum C-reactive protein concentrations were higher in nonhypertensive offspring with 1 (median: 1.7; Q1 to Q3: 0.8 to 3.6 mg/L) or both parents with hypertension (median: 1.8; Q1 to Q3: 0.7 to 3.6 mg/L) compared with offspring without parental hypertension (median: 1.4; Q1 to Q3: 0.7 to 3.2 mg/L). In multivariable analyses, parental hypertension was associated with higher serum C-reactive protein concentration in offspring (15% increase per parent with hypertension; Pϭ0.004). Prospectively, the relation of parental hypertension to longitudinal changes in blood pressure in the nonhypertensive offspring was attenuated on adjustment for C-reactive protein (Pϭ0.04 for attenuation). The levels of the other biomarkers evaluated did not significantly differ in offspring according to parental hypertension status. In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk. Key Words: hypertension Ⅲ offspring Ⅲ biomarkers Ⅲ C-reactive protein E levated blood pressure (BP) is an important vascular risk factor associated with increased cardiovascular morbidity and mortality. 1 Hypertension (HTN) is a condition with an enormous public health burden, affecting almost one third of all adults in the United States and is associated with substantial health care expenditure. 2 Consequently, prevention of HTN is a public health priority.The underlying pathophysiology of elevated BP, however, is incompletely understood. BP is considered a complex trait influenced by several environmental and genetic factors, with Ϸ30% to 60% of the interindividual variation in BP being attributed to additive genetic factors. 3,4 It is well established that HTN clusters in families 5 and that a positive family history represents a major risk factor for future HTN in nonhypertensive offspring. 6 Recent studies have indicated that circulating concentrations of several biomarkers that represent distinct biological pathways are correlated with BP levels cross-sectionally and are associated with a greater incidence of HTN prospectively. 7-11 For instance, a recent investigation from the Framingham Heart Study demonstrated that circulating concentrati...

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Section: Crp and Htnmentioning

confidence: 58%

Association of Parental Hypertension With Concentrations of Select Biomarkers in Nonhypertensive Offspring

et al. 2008

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“…27 Furthermore, borderline hypertension is correlated with an excessive increase in albuminuria. 28 F I G U R E 1 Rest albumin-tocreatinine ratio (ACR) and post-exercise ACR differed significantly between normotensive and hypertensive patients (P < 0.0001 for both and for comparison between the four bars). P < 0.001 for all.…”

Section: Discussionmentioning

confidence: 96%

“…An accelerated change in ACR over time also correlates with hypertension in individuals with normal kidney function and normoalbuminuria . Furthermore, borderline hypertension is correlated with an excessive increase in albuminuria …”

Section: Discussionmentioning

confidence: 97%

Hypertension is associated with increased post‐exercise albuminuria, which may be attenuated by an active lifestyle

Grupper

Ehrenwald

Schwartz

et al. 2019

J of Clinical Hypertension

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Albuminuria is a known marker for endothelial dysfunction and cardiovascular events, even below the threshold of moderately increased albuminuria (MIA). Post‐exercise increased albuminuria may precede the appearance of rest MIA, enabling detection of early injury. Modifying lifestyle for a population at risk for MIA is therefore of interest. Our aim was to evaluate post‐exercise albuminuria in hypertensive compared with normotensive individuals and to analyze the effect of an active lifestyle on rest and post‐exercise albumin excretion. The study cohort consisted of 3931 adults who participated in a health‐screening program. Albuminuria was measured as urine albumin‐to‐creatinine ratio (ACR). Lifestyle was divided into three groups: non‐active, less‐active, and active according to regular sport activity, categorized as follows: none, <2.5 and ≥2.5 hours per week. Mean age was 47.7 years, and 31.2% (n = 1228) were diagnosed with hypertension. Both rest and post‐exercise ACR were higher in hypertensive compared to normotensive participants. Rest ACR was higher in non‐active compared to less‐active and active hypertensive participants. Hypertensive participants with an active lifestyle had significantly lower post‐exercise and delta ACR compared to less‐active and non‐active hypertensive participants. Parameters related to delta ACR in hypertensive participants were increased age, BMI, and diabetes, while active lifestyle and fitness (measured as METS achieved by a stress test) were protective. In conclusion, there is an association between hypertension and increased albumin excretion post‐exercise, which can be attenuated with an active lifestyle.

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“…In addition to age and gender, body mass index, exercise, and a high protein meal can affect MA. Measurement can be further confounded by fever, sepsis, congestive heart failure, and urinary tract infection (9, 10).…”

Section: Ma and Endothelial Dysfunctionmentioning

confidence: 99%

Microalbuminuria in Cerebrovascular Disease: A Modifiable Risk Factor?

Rocco

Heerlein

Diedler

et al. 2010

International Journal of Stroke

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Stroke is potentially preventable through risk factor modification. Over the past decade, there has been considerable interest on microalbuminuria as a risk factor for chronic diseases. The concept of microalbuminuria was originally introduced, about 25 years ago, to clinical practice as a useful marker of nephropathy. Since then various studies reported an association of microalbuminuria with the increased risk of cardiovascular events and all cause of mortality in subjects with or without diabetes. The presence of microalbuminuria was related to left ventricular dysfunction, stroke, and myocardial infarction. Microalbuminuria may be a predictor of stroke but further studies are required. However data on prognostic significance and therapeutic consequence, particularly in haemorrhagic stroke are lacking. This review focuses on the importance of microalbuminuria for cerebrovascular disease, stressing the clinical and therapeutic implications using antihypertensive therapy to control the urinary albumin excretion.

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The influence of exercise on albumin excretion rate in borderline hypertensives and in offspring of hypertensive parents

Abstract: We investigated exercise induced urinary albuminThe three groups did not differ in 24 h UAE. Exercise excretion rate (UAE) (ex-UAE) in patients with borderline induced a significant increase in UAE only in BH. Exerhypertension (

Cited by 8 publications

References 8 publications

Association of Parental Hypertension With Concentrations of Select Biomarkers in Nonhypertensive Offspring

Association of Parental Hypertension With Concentrations of Select Biomarkers in Nonhypertensive Offspring

Hypertension is associated with increased post‐exercise albuminuria, which may be attenuated by an active lifestyle

Microalbuminuria in Cerebrovascular Disease: A Modifiable Risk Factor?

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