Increased Type 2 Diabetes Mellitus Risk (Assessed by Findrisc Score) is Associated with Subclinical Atherosclerotic Markers in Asymptomatic Adult Population

Mitu, Ovidiu; Mitu, Florin; Leon, Maria-Magdalena; Roca, Mihai; Gherasim, Andreea; Graur, Mariana

doi:10.1515/rjdnmd-2016-0005

Cited by 2 publications

(2 citation statements)

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“…T2DM is a threat to public health worldwide in view of its epidemic nature and effect on a number of health outcomes [ 16 ]. T2DM increases the risk of developing atherosclerosis [ 17 ], dyslipidemia [ 18 ], and hypertension [ 19 ], all of which are leading causes of death in both developed and developing countries. Owing to a rapidly changing lifestyle, the scale of this epidemic is of similar proportions in Jordan [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan

et al. 2018

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BackgroundDiabetes mellitus is a global public health problem that is caused by the lack of insulin secretion (type 1) or resistance to its action (type 2). A low insulin-to-glucagon ratio predicts an increase in the serum levels of branched chain amino acids, a feature confirmed in several populations. This relationship has not been assessed in Jordan. The objective of this study was to investigate the association between serum branched chain amino acids and type 2 diabetes mellitus in patients in Jordan.MethodsTwo hundred type 2 diabetes mellitus patients and an additional 200 non-diabetic controls were recruited. Age, body mass index, and waist circumference of the subjects were recorded. Branched chain amino acid, total cholesterol, and triglyceride levels were measured from the collected serum samples.ResultsSerum branched chain amino acid levels were significantly higher in type 2 diabetes mellitus patients than in non-diabetes individuals (P<0.0001). In binomial regression analysis, serum branched chain amino acid levels remained significantly associated with diabetes mellitus and increased its risk (odds ratio, 1.004; 95% confidence interval, 1.001–1.006; P=0.003).ConclusionType 2 diabetes mellitus is associated with higher branched chain amino acid levels in Jordan independent of age, sex, body mass index, waist circumference, and total serum cholesterol and serum triglyceride levels.

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Section: Discussionmentioning

confidence: 99%

Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan

et al. 2018

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“…It has however not known to be used in younger population in Africa. Reports from other studies indicated much higher age of 35-75 years of age (14)(15)(16)(17).…”

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confidence: 93%

Utility Of Finnish Diabetes Risk Score In A Young Adult Population In An Urban Setting In Africa

Malindisa¹,

Balandya²,

Mashili³

et al. 2019

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Background The prevalence of type 2 diabetes mellitus (T2D) and other NCDs is on the rise globally, low-income countries like Tanzania are not spared. Affordable and effective screening tools are needed to combat these epidemics. This study aimed to evaluate the utility and applicability of the Finnish Diabetes Risk Score (FINDRISC) as one of the screening tools for T2D and its potential risk factors in population of young adults from an urban setting in Tanzania. Methods A community based cross-sectional study was conducted in urban setting Mwanza-Tanzania. Data was collected using FINDRISC questionnaire (assessing Age, BMI, waist circumference, physical activity participation, vegetable consumption, and history of high blood pressure, history of high blood sugar and family history of diabetes) and physical assessment of, blood pressure, waist circumference and hip circumference. Laboratory measurements for fasting blood glucose, oral glucose tolerance and lipid profile. Data was analyzed using STATA 13. Pearson’s correlation was used to assess the associations between FINDRISC with clinical and biochemical parameters. Linear regression was used to assess the extent at which FINDRISC predicted various clinical and biochemical parameters. P-value was considered significant at p≤0.05. Results Of the 259 participants enrolled, 32.8% were in the FINDRISC categories of “at least slightly elevated risk” to “high risk” of developing T2D in 10 years’ time. FINDRISC correlated with FBG (r=0.12, p=0.05), diastolic blood pressure (r=0.19, p=0.02), mean arterial blood pressure (r=0.13, p=0.036), low density lipoprotein cholesterol (r=0.19, p =0.005), and waist to hip ratio - WHR (r=0.34, p = 0.001). Furthermore, FINDRISC explained 11% of the variation in WHR (Adjusted r2 = 0.11, p=0.001), 3% of diastolic blood pressure (adjusted r2= 0.03, p = 0.02), 3% of low density lipoprotein cholesterol (adjusted r2=0.03, p=0.005), 1% of mean arterial pressure (adjusted r2=0.01, p=0.036) and 1% of FBG (r2=0.01, p=0.05). Conclusion This study provides novel insights on the potential utility of FINDRISC as a simple and non-invasive screening tool for metabolic syndrome-related ailments among young adults in Africa. Longitudinal studies, with context-specific modifications of FINDRISC, are suggested to ascertain its predictive value for future T2D in this population.

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Increased Type 2 Diabetes Mellitus Risk (Assessed by Findrisc Score) is Associated with Subclinical Atherosclerotic Markers in Asymptomatic Adult Population

Abstract: Background and Aims. Risk score questionnaires for the screening of type 2 diabetes mellitus (DM) present high accuracy, especially the Finnish Diabetes Risk Score (FINDRISC IMT (r=0.24, p=0.01), PWV (r=0.26, p=0.008) or LVMI (r=0.23, p=0.01)

Cited by 2 publications

References 25 publications

Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan

Serum Branched Chain Amino Acids Are Associated with Type 2 Diabetes Mellitus in Jordan

Utility Of Finnish Diabetes Risk Score In A Young Adult Population In An Urban Setting In Africa

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