“…Furthermore, some children show a discordant response to HAART characterized by a significant increase in CD4 + T cell counts, despite persistent detectable viraemia [15,16,[19][20][21][22]. Although the mechanisms of this discordant response to HAART have not been elucidated fully, it has been suggested that thymic output [15,16,19,23] and an impaired replicative capacity of drug-resistant viruses [20,24,25] might be involved.…”