Increased Thrombopoietin and Mean Platelet Volume in Patients With Ischemic Stroke

Varol, Ercan

doi:10.1177/1076029612459677

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…The current study also showed that the total platelet count of patients in the AF+TE group was higher than that in patients in the AF group, which may be due to the high turnover rate of platelets or the transient reduction in platelets among patients with AF complicated by TEs. These results are in accordance with those of Varol (16). Alhaji et al (17) calculated the left atrial volume index by measuring LAD, and found that it was an independent risk factor for stroke.…”

supporting

confidence: 89%

The association between mean platelet volume and chronic atrial fibrillation and the presence of thrombotic events

Jiang

et al. 2015

Biomedical Reports

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Abstract. Mean platelet volume (MPV), a marker of platelet activation, is a surrogate marker of platelet function and a potential mediator of the association between inflammation and thrombosis. The present retrospective study sought to investigate the association between MPV and the presence of thrombotic events (TEs) in patients with chronic atrial fibrillation (AF). A total of 114 consecutive patients with chronic AF were enrolled from a Chinese hospital. Individuals were divided into three groups: The AF+TE group (n=57, 33.1%), which comprised patients in AF with concomitant TEs; the AF group (n=57, 33.1%), which comprised patients in AF with no identifiable TEs, as confirmed by brain computed tomography, transesophageal echocardiography, or a combination of the two; and a control group (n=58, 33.7%), which consisted of patients who were in sinus rhythm. MPV, high-sensitivity C-reactive protein (hsCRP), D-dimer and the left atrial diameter (LAD) were analyzed in the 172 participants. The MPV level of patients in the AF+TE group was significantly higher than that of patients in the AF and control groups (P<0.05). In the correlation analysis, MPV levels were found to be positively correlated with LAD, D-dimer concentrations and hsCRP levels in patients with AF (r=0.960, P<0.05; r=0.896, P<0.05; and r=0.924, P<0.01, respectively). In the receiver operating characteristic curve analysis, the value for MPV levels required to detect TEs with a sensitivity of 77.5% and specificity of 78% was 10.5 femtoliter (fl). A high MPV level (>10.5 fl) was significantly associated with the occurrence of TEs (odds ratio, 3:1; 95% confidence interval, 1.6-5.1; P=0.000). The results of the present study suggest that an additional biomarker, MPV, has a predictive value for the presence of TEs in patients with AF. MPV may be a potential mediator between inflammation and thrombosis.

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confidence: 89%

The association between mean platelet volume and chronic atrial fibrillation and the presence of thrombotic events

Jiang

et al. 2015

Biomedical Reports

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“…Abnormal MPV has been correlated with thrombotic and inflammatory conditions, such as myocardial infarction, acute cerebral ischemia, inflammatory bowel disease, rheumatoid arthritis, and familial Mediterranean fever [16][17][18][19][20]; however, the relationship between MPV and AP has not been fully clarified, especially hypertriglyceridemia-induced SAP during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Zeng

Cai

Chen

et al. 2020

BMC Pregnancy Childbirth

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Background Hypertriglyceridemia-induced acute pancreatitis during pregnancy (HTG-APP) is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-APP remains unclear. Methods In the retrospective study, we collected 45 patients with HTG-APP as the HTG-APP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results MPV were significantly higher in the HTG-APP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Logistic regression analyses revealed that MPV was significantly associated with SAP (odds ratio = 2.077, 95% confdence interval, 1.038–4.154; P = 0.039). Conclusions These results may indicate an important role of mean platelet volume in evaluating the severity of HTG-APP.

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“…Abnormal MPV has been correlated with thrombotic and in ammatory conditions, such as myocardial infarction, acute cerebral ischemia, inflammatory bowel disease, rheumatoid arthritis, and familial Mediterranean fever [16][17][18][19][20]; however, the relationship between MPV and AP has not been fully clari ed, especially hypertriglyceridemiainduced SAP during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Since the main purpose of this study was to distinguish SAP in the early stage of the disease, MSAP and MAP were merged with the Non SAP group, while AP with SAP was considered the SAP group. We de ned gestational age as the rst (before 12 weeks), second (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) weeks), and third trimesters (28 weeks until delivery).…”

Section: Patient Enrollmentmentioning

confidence: 99%

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Zeng

Cai

Chen

et al. 2020

Preprint

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Background: Hypertriglyceridemia-induced acute pancreatitis during pregnancy (HTG-APP) is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-APP remains unclear.Methods: In the retrospective study, we collected 45 patients with HTG-APP as the HTG-APP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared. Results: MPV were significantly higher in the HTG-APP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010). Logistic regression analyses revealed that MPV was significantly associated with SAP (odds ratio = 2.077, 95% confdence interval, 1.038-4.154; P = 0.039). Conclusions: These results may indicate an important role of mean platelet volume in evaluating the severity of HTG-APP.

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Increased Thrombopoietin and Mean Platelet Volume in Patients With Ischemic Stroke

Cited by 8 publications

References 7 publications

The association between mean platelet volume and chronic atrial fibrillation and the presence of thrombotic events

The association between mean platelet volume and chronic atrial fibrillation and the presence of thrombotic events

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

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