Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Zeng, Longhuan; Cai, X. Y.; Chen, Jiayi; Jin, Guangyong; Zheng, Yongke

doi:10.21203/rs.2.12665/v3

Cited by 1 publication

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rates of local complications and organ failure increase significantly and dose-dependently with the level of triglycerides (8). The trend of HTG-induced AP has been observed to increase with the gestational age and number of pregnancies (9). This disease constitutes a systemic inflammatory process accompanied by thrombosis, and bleeding disorders result in multiple organ dysfunction and disseminated intravascular coagulation (9).…”

Section: Discussionmentioning

confidence: 99%

“…The trend of HTG-induced AP has been observed to increase with the gestational age and number of pregnancies (9). This disease constitutes a systemic inflammatory process accompanied by thrombosis, and bleeding disorders result in multiple organ dysfunction and disseminated intravascular coagulation (9). Yang et al showed that HTGinduced AP along with a delayed diagnosis was related to a 66.7% fetal loss (10).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multidisciplinary diagnosis and treatment of severe acute pancreatitis associated with hypertriglyceridemia in pregnancy: a case report

Li¹,

Wang²,

Li³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background Hypertriglyceridemia (HTG) is an important cause of acute pancreatitis (AP) in pregnant women. Due to the variable clinical features of acute pancreatitis, it is difficult to make a differential diagnosis when abdominal pain occurs in late pregnancy. Severe HTG induced acute pancreatitis during pregnancy is rare, but may be a fatal threat to both mothers and fetuses during the peripartum period, and can increase maternal and fetal mortality. If emotional disorder combined, difficulty of treatment increased. So, multidisciplinary diagnosis combination of psychiatric treatment could improve the diagnosis rate and cure rate of acute pancreatitis during pregnancy. Case Description We present the case of a 27-year-old Chinese woman in her first pregnancy, who was admitted to the hospital in the planned delivery period, but then developed progressive abdominal pain and whose biochemistry parameters were high enough to underwent a cesarean section as a result of AP a few hours after admission. The patient developed organ failure after a successful labor, which rapidly evolved to multi-organ failure, accompanied by depressive symptoms. Afterwards She appeared such as agitated, uneasy, and sad, and did not comply with the treatment, according to the classification of symptoms and course of disease, postpartum depression (PPD) was highly suspected. The patient benefited from multidisciplinary treatments that combined and integrated traditional Chinese medicine (TCM) with Western medicine therapies. The patient was discharged 35 days after her admission. Conclusions This case highlights the importance of monitoring and managing excess dyslipidemia during pregnancy. A proactive strategy should be encouraged in the management of the patients with high risk of pancreatitis to improve the outcomes of patients. Our case report elucidates the possible long-term effects of HTG and reminds us of the need for long-term management of those affected.

show abstract

Section: Discussionmentioning

confidence: 99%