Increased T‐Cell Activation in Decidua Parietalis Compared to Decidua Basalis in Uncomplicated Human Term Pregnancy

Sindram-Trujillo, Aliana P; Scherjon, Sicco A.; Kanhai, Humphrey H.H.; Roelen, Dave L.; Claas, Frans H.J.

doi:10.1034/j.1600-0897.2003.00041.x

Cited by 67 publications

(67 citation statements)

References 53 publications

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“…These results coincide with previous studies demonstrating that choriodecidual leukocytes express CAMs [16,39,40], cytokines [8,41,42], chemokines [16,34], and their receptors [16,34,43], enzymes [35,44,45], antimicrobial peptides [46], markers of activation [17,39,[47][48][49], and even hormone receptors [50] before and during the process of labor. Together, these findings demonstrate that the choriodecidual leukocytes are a rich source of inflammatory mediators that can participate in the proinflammatory milieu that accompanies the process of labor.…”

Section: Resultssupporting

confidence: 81%

“…This interface includes two areas of contact between the mother and the fetus: the decidua parietalis, which lines the uterine cavity not covered by the placenta and is juxtaposed to the chorion laeve; and the decidua basalis, which lays on the basal plate of the placenta and is invaded by the interstitial trophoblast [16,17]. Decidua parietalis is composed of stroma-type cells, glandular cells, and leukocytes [18][19][20][21], and the portion that is attainable is attached to the chorioamniotic membranes; therefore, this anatomical site is known as the choriodecidua [16].…”

Section: Introductionmentioning

confidence: 99%

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Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term

et al. 2018

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Prior to and during the process of human labor, maternal circulating leukocytes infiltrate the maternal-fetal interface (choriodecidua) and become activated resembling choriodecidual leukocytes. Since, there is no evidence comparing maternal circulating and choriodecidual leukocytes, herein, we characterized their transcriptome and explored the biological processes enriched in choriodecidual leukocytes. From women undergoing spontaneous term labor we isolated circulating and choriodecidual leukocytes, performed microarray analysis (n = 5) and qRT-PCR validation (n = 9) and interaction network analysis with up-regulated genes. We found 270 genes up-regulated and only 17 genes down-regulated in choriodecidual leukocytes compared to maternal circulating leukocytes. The most up-regulated genes were CCL18, GPNMB, SEPP1, FN1, RNASE1, SPP1, C1QC, and PLTP. The biological processes enriched in choriodecidual leukocytes were cell migration and regulation of immune response, chemotaxis, and humoral immune responses. Our results show striking differences between the transcriptome of choriodecidual and maternal circulating leukocytes. Choriodecidual leukocytes are enriched in immune mediators implicated in the spontaneous process of labor at term.

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Section: Resultssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term

et al. 2018

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“…However, the variation in suppression capacity between the samples might be due to a different leukocyte composition of the isolates. Decidual T cells comprise a very heterogeneous subset of T cells containing CD4 ϩ and CD8 ϩ cells with highly activated phenotypes as well as cells with a merely regulatory phenotype (13,16). The activated decidual T cells might be more difficult to suppress in comparison with peripheral blood T cells, resulting in similar suppression indexes.…”

Section: Cd25mentioning

confidence: 99%

“…These data suggest that T cells play a role in specific immune tolerance to fetal alloantigens in murine pregnancy. Recent studies have shown that high percentages of T cells are present in decidual tissue in human term pregnancy and that peripheral blood T cell subsets change during pregnancy (13)(14)(15)(16). In addition, a significantly higher percentage of CD4 ϩ…”

mentioning

confidence: 97%

Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy

Tilburgs

Roelen

Mast

et al. 2008

The Journal of Immunology

324

278

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During pregnancy, the maternal immune system has to tolerate the persistence of fetal alloantigens. Many mechanisms contribute to the prevention of a destructive immune response mediated by maternal alloreactive lymphocytes directed against the allogeneic fetus. Murine studies suggest that CD4+CD25+ T cells provide mechanisms of specific immune tolerance to fetal alloantigens during pregnancy. Previous studies by our group demonstrate that a significantly higher percentage of activated T cells and CD4+CD25bright T cells are present in decidual tissue in comparison with maternal peripheral blood in human pregnancy. In this study, we examined the phenotypic and functional properties of CD4+CD25bright T cells derived from maternal peripheral blood and decidual tissue. Depletion of CD4+CD25bright T cells from maternal peripheral blood demonstrates regulation to third party umbilical cord blood cells comparable to nonpregnant controls, whereas the suppressive capacity to umbilical cord blood cells of her own child is absent. Furthermore, maternal peripheral blood shows a reduced percentage of CD4+CD25brightFOXP3+ and CD4+CD25brightHLA-DR+ cells compared with peripheral blood of nonpregnant controls. In contrast, decidual lymphocyte isolates contain high percentages of CD4+CD25bright T cells with a regulatory phenotype that is able to down-regulate fetus-specific and fetus-nonspecific immune responses. These data suggest a preferential recruitment of fetus-specific regulatory T cells from maternal peripheral blood to the fetal-maternal interface, where they may contribute to the local regulation of fetus-specific responses.

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“…During this process, the decidual environment is infiltrated by a large number of leukocytes, which predominantly include CD56 + CD16 -NK cells (~70%), macrophages (~10%) and T cells (~10%) (2,3). Previous studies have demonstrated that T cells have an important physiological role in early pregnancy (4).…”

Section: Introductionmentioning

confidence: 99%

Expansion of decidual CD45RO+ T cells with high expression of CEACAM1 in the early stage of pregnancy

Xie

Wang

Zhang

et al. 2013

Molecular Medicine Reports

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Increased T‐Cell Activation in Decidua Parietalis Compared to Decidua Basalis in Uncomplicated Human Term Pregnancy

Abstract: These findings suggest that there are more activated T cells in decidua parietalis than in decidua basalis. Further investigation into differences between the two decidual sites may expand our understanding of the immunology of the maternal-fetal interface.

Cited by 67 publications

References 53 publications

Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term

Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term

Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy

Expansion of decidual CD45RO+ T cells with high expression of CEACAM1 in the early stage of pregnancy

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