Expansion of decidual CD45RO+ T cells with high expression of CEACAM1 in the early stage of pregnancy

Xie, Qi; Wang, Qingjie; Zhang, Yun; Kong, Beihua; Dong, Bo; Qu, Xun

doi:10.3892/mmr.2013.1552

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…Xie et al. have already hypothesized that the trophoblast cells may be involved in pronounced CEACAM1 expression on the decidual CD45RO+ T cells during the implantation process . The fact that our samples were collected in the “late” first trimester, where the immune tolerance shifts toward Th2 conditions, may be an explanation for the non‐significant difference between CEACAM1 levels in the first and second trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 88%

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Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy

Mach

Gellhaus

Prager

et al. 2017

American J Rep Immunol

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Section: Discussionmentioning

confidence: 88%

“…Moreover, Xie et al. showed that trophoblast cells may be involved in the increase of CEACAM1 expression on the surface of decidual CD45RO+ T cells in the feto–maternal interface . CEACAM6 also plays a role in the regulation of CD8+ T‐cell responses in multiple myeloma patients .…”

Section: Introductionmentioning

confidence: 99%

Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy

Mach

Gellhaus

Prager

et al. 2017

American J Rep Immunol

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show abstract

“…Our results support the hypothesis of immunological maladaptation and increased immune system activity in PE in the first trimester, where T cells play a crucial role. CEACAM1 is overexpressed on the surface of the CD4+CD45+RO T cells in the feto‐maternal border zone in the first trimester 20 . Because CEACAM1 influences T‐cell function, sCEACAM1 could indirectly demonstrate an immunomodulatory effect in the first trimester.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, its role during pregnancy is barely understood. CEACAM1 is expressed in the decidual T cells in first trimester, playing a significant role in trophoblast invasion 19,20 . In our previous study, we showed that soluble CEACAM1 (sCEACAM1) is involved in the regulation of the immune tolerance during a physiological pregnancy, playing a role in the proper development of the fetus and parturition 21 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of carcinoembryonic antigen‐related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsia

Mach

Andrikos

Schmidt

et al. 2020

American J Rep Immunol

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Problem The aim of this study was to evaluate the sCEACAM1 concentrations in serum from patients in the first trimester who have a high risk for developing PE during pregnancy. Method of the study Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) levels were determined with ELISA. The patients (n = 109) were divided into two groups: patients who have a high risk of developing PE early‐onset and a control group. Patients who have a high risk of developing PE were then divided into two subgroups depending on PE development in third trimester of pregnancy: PE in third trimester versus no PE in third trimester. Results sCEACAM1 concentrations in patients who were screened as having a high risk for developing PE were significantly higher than in healthy pregnant women in the first trimester (p = .03). The highest sCEACAM1 concentration was found in the high‐risk group with PE development compared to the control group (p = .004). Conclusion Elevated sCEACAM1 blood serum levels in women with PE suggest that there is immune dysregulation in early pregnancy, which may be helpful in PE prediction and therapy.

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Altered Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1/T-Cell Immunoglobulin Mucin-3 Signaling Causes the Dysregulation of Decidual CD8+T Cells in the Third Trimester during Preeclamptic Pregnancies

Zhang

Chen

Wang

et al. 2021

Reproductive and Developmental Medicine

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Objective: To investigate the frequency and function of Tim-3+CD8+T cells in the third trimester of normal pregnancies (NPs) and preeclamptic (PE) pregnancies. Methods: T-cell immunoglobulin mucin-3 (Tim-3) expression levels of CD8+T cells in the decidua, peripheral blood, and umbilical cord blood obtained from women showing NPs and PE pregnancies were analyzed using flow cytometry. Decidual CD8+T cells were cultured in the presence of recombinant human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) protein and/or Tim-3-specific neutralizing antibodies for analyzing CD107a and intracellular cytokine expression. The placental CEACAM1 protein expression was analyzed using immunohistochemistry. Results: Tim-3+CD8+T cells were more abundant in the decidua than in the peripheral blood. Tim-3 expression in the decidual CD8+T cells was significantly lower in PE patients. Decidual Tim-3+CD8+T cells from PE patients expressed higher levels of CD107a and the Th1-type cytokine IFN-γ, but lower levels of the Th2-type cytokine IL-4. CEACAM1 altered the CD107a, IFN-γ, and IL-4 levels; this was reversed by anti-Tim-3 antibodies. The CEACAM1 protein levels were lower in the placental tissues of women with PE pregnancies than in those of women with NPs. Conclusions: Abnormal CEACAM1/Tim-3 regulation may participate in the development of PE, accompanied by disturbed Th2 cell predominance and higher cytotoxicity of decidual CD8+T cells.

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Expansion of decidual CD45RO+ T cells with high expression of CEACAM1 in the early stage of pregnancy

Cited by 3 publications

References 33 publications

Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy

Soluble CEACAM1 and CEACAM6 are differently expressed in blood serum of pregnant women during normal pregnancy

Evaluation of carcinoembryonic antigen‐related cell adhesion molecule 1 blood serum levels in women at high risk for preeclampsia

Altered Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1/T-Cell Immunoglobulin Mucin-3 Signaling Causes the Dysregulation of Decidual CD8+T Cells in the Third Trimester during Preeclamptic Pregnancies

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