Increased Sympathetic and Decreased Parasympathetic Cardiac Innervation in Patients With Alzheimer's Disease

Aharon‐Peretz, Judith; Harel, Tamar; Revach, Moshe; Ben‐Haim, Shlomo A.

doi:10.1001/archneur.1992.00530330041013

Cited by 87 publications

(37 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, MCI is considered a condition of predementia and a number of studies have demonstrated an impaired autonomic function in dementia, whether by clinical autonomic tests [12]–[16] or HRV analysis [17]–[21]. Also, a recent study has shown that, within a group of patients with Alzheimer's disease (AD), there was a positive correlation between cognitive status and parasympathetic HRV indices [22].…”

Section: Introductionmentioning

confidence: 99%

Autonomic Dysfunction in Mild Cognitive Impairment: Evidence from Power Spectral Analysis of Heart Rate Variability in a Cross-Sectional Case-Control Study

et al. 2014

View full text Add to dashboard Cite

BackgroundMild cognitive impairment (MCI) is set to become a major health problem with the exponential ageing of the world's population. The association between MCI and autonomic dysfunction, supported by indirect evidence and rich with clinical implications in terms of progression to dementia and increased risk of mortality and falls, has never been specifically demonstrated.AimTo conduct a comprehensive assessment of autonomic function in subjects with MCI by means of power spectral analysis (PSA) of heart rate variability (HRV) at rest and during provocative manoeuvres.MethodsThis cross-sectional study involved 80 older outpatients (aged ≥65) consecutively referred to a geriatric unit and diagnosed with MCI or normal cognition (controls) based on neuropsychological testing. PSA was performed on 5-minute electrocardiographic recordings under three conditions—supine rest with free breathing (baseline), supine rest with paced breathing at 12 breaths/minute (parasympathetic stimulation), and active standing (orthosympathetic stimulation)—with particular focus on the changes from baseline to stimulation of indices of sympathovagal balance: normalized low frequency (LFn) and high frequency (HFn) powers and the LF/HF ratio. Blood pressure (BP) was measured at baseline and during standing. Given its exploratory nature in a clinical population the study included subjects on medications with a potential to affect HRV.ResultsThere were no significant differences in HRV indices between the two groups at baseline. MCI subjects exhibited smaller physiological changes in all three HRV indices during active standing, consistently with a dysfunction of the orthosympathetic system. Systolic BP after 10 minutes of standing was lower in MCI subjects, suggesting dysautonomia-related orthostatic BP dysregulation.ConclusionsOur study is novel in providing evidence of autonomic dysfunction in MCI. This is associated with orthostatic BP dysregulation and the ongoing follow-up of the study population will determine its prognostic relevance as a predictor of adverse health outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Autonomic Dysfunction in Mild Cognitive Impairment: Evidence from Power Spectral Analysis of Heart Rate Variability in a Cross-Sectional Case-Control Study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The model can reliably fit experimental PLR data to extract individual contributions from parasympathetic and sympathetic activities. Abnormal parasympathetic and/or sympathetic activities have been linked to many disorders, such as panic disorder [32], migraine [33], Parkinson’s disease [34], Alzheimer’s disease [35], and autism spectrum disorders [36]. The capability to extract specific parasympathetic- and sympathetic-related parameters from PLR measurements can provide more accurate diagnostic information on ANS functions.…”

Section: Discussionmentioning

confidence: 99%

Modeling Transient Pupillary Light Reflex Induced by a Short Light Flash

Fan

Yao

2011

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

A pupillary light reflex (PLR) model was proposed in this paper by considering the iris muscle mechanical properties and modulation inputs from both parasympathetic and sympathetic systems. The model can describe very well the experimental PLR responses induced by a short light flash of various intensities. In addition, an inverse method was developed to fit numerically this model to experimental PLR data. The model was tested in experimental human PLR data to extract separately the parasympathetic and sympathetic modulations during PLR. The results indicated a higher parasympathetic and a lower sympathetic activity in females than in males, which was consistent with previous findings in cardiovascular studies. This new model may help improve our understanding of the PLR process and could be applied to analyze autonomic nervous interaction during pupillary responses.

show abstract

“…Note that the heart rates of the BDNF+/-mice were greater than the heart rates of the control mice during both the night and daytime periods autonomic functions were applied to 29 AD patients and 15 control subjects; the results provided evidence for parasympathetic dysfunction in the AD patients (Algotsson et al 1995). Compared with age-matched neurologically normal subjects, AD patients exhibited changes in heart rate variability suggestive of a hypoparasympathetic state (Aharon-Peretz et al 1992). The increased sensitivity of the pupil to dilation induced by tropicamide in AD patients may result from impaired noradrenergic activity as the result of locus coeruleus dysfunction and impaired parasympathetically mediated pupil constriction (Hou et al 2006).…”

Section: Ans Dysfunction In Neurodegenerative and Psychiatric Disordersmentioning

confidence: 92%

Neurotrophic Factors in Autonomic Nervous System Plasticity and Dysfunction

Mattson

Wan

2008

Neuromol Med

View full text Add to dashboard Cite

During development, neurotrophic factors are known to play important roles in regulating the survival of neurons in the autonomic nervous system (ANS) and the formation of their synaptic connectivity with their peripheral targets in the cardiovascular, digestive, and other organ systems. Emerging findings suggest that neurotrophic factors may also affect the functionality of the ANS during adult life and may, in part, mediate the effects of environmental factors such as exercise and dietary energy intake on ANS neurons and target cells. In this article, we describe the evidence that ANS neurons express receptors for multiple neurotrophic factors, and data suggesting that activation of those receptors can modify plasticity in the ANS. Neurotrophic factors that may regulate ANS function include brain-derived neurotrophic factor, nerve growth factor, insulin-like growth factors, and ciliary neurotrophic factor. The possibility that perturbed neurotrophic factor signaling is involved in the pathogenesis of ANS dysfunction in some neurological disorders is considered, together with implications for neurotrophic factor-based therapeutic interventions.

show abstract

Increased Sympathetic and Decreased Parasympathetic Cardiac Innervation in Patients With Alzheimer's Disease

Cited by 87 publications

References 19 publications

Autonomic Dysfunction in Mild Cognitive Impairment: Evidence from Power Spectral Analysis of Heart Rate Variability in a Cross-Sectional Case-Control Study

Autonomic Dysfunction in Mild Cognitive Impairment: Evidence from Power Spectral Analysis of Heart Rate Variability in a Cross-Sectional Case-Control Study

Modeling Transient Pupillary Light Reflex Induced by a Short Light Flash

Neurotrophic Factors in Autonomic Nervous System Plasticity and Dysfunction

Contact Info

Product

Resources

About