Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice

Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

“…A role for immune responses has been implicated in the resistance of adult mice to tumor development, since experimental or genetic immunoincompetence partially restores the tumor induction potential (2,183,190,305). Nonimmune factors are also involved, since the replication potential declines significantly with the age of the mouse, regardless of its immune status (334).…”

Mouse Mammary Tumour Virus and Polyoma Virus Information in Mammary Tumours of Athymic Mice Inoculated with Polyoma Virus

“…Initially, it was found necessary to inoculate mice in the early neonatal period to induce tumours, presumably to escape cellular immune resistance. More recently, it has been possible to induce tumours in athymic mice inoculated with polyoma virus as adults (Allison & Taylor, 1967;Allison et al, 1974;Vandeputte et al, 1963Vandeputte et al, , 1974. The relative incidence of the different tumour types varied in these studies.…”

Comparison of Lung Tumorigenesis Induced by Urethan in Athymic Nude Mice and Euthymic Littermates

“…On the other hand, oncogenic virus-induced carcinogenesis [3][4][5][6] and oncogenesis by some carcinogenic chemicals, such as methylnitrosourea, ethylnitrosourea and dimethylbenzanthracene [13,14] , support the concept of the immunosurveillance theory. In those studies, athymic nude mice developed more tumors than euthymic mice.…”

“…However, earlier studies using athymic nude mice showed discrepant results depending on the experimental conditions. This immunosurveillance theory was generally supported in tumors induced by oncogenic viruses [3][4][5][6] and spontaneous lymphoreticular neoplasms [7,8]. However, this was not the case in chemical carcinogenesis ; many investigators reported that the latent period and tumor incidence in nude mice treated with urethan or methylcholanthrene were not significantly different from those in euthymic control mice [8- Animals : Male athymic nude mice (nu/ nu) and their female heterozygous littermates (nu/+) with a BALB/c background were supplied by the animal breeding facility of this institute, and then mated in our laboratory.…”