Comparison of Lung Tumorigenesis Induced by Urethan in Athymic Nude Mice and Euthymic Littermates

Kobayashi, Shigeru; Otsu, Hiroshi; Noda, Yuko

doi:10.1538/expanim1978.43.3_351

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Surprisingly, previous studies using a primary lung carcinogenesis murine model seem to indicate that the adaptive immune system does not significantly contribute to immunosurveillance for lung cancer. For example, in a urethane-induced model of lung cancer, the latency period, penetrance, and total number of tumors was similar between athymic nude (nu/nu) mice, which lack a thymus and thus thymically-derived T cells (61, 62), and euthymic (nu/+) littermate controls (63). Since the thymus is involved in the development of the majority of T cells (61, 62), these studies suggest that T cells do not significantly contribute to tumor immunosurveillance in the lung.…”

Section: The Role Of Nk Cells In Pulmonary Immunosurveillancementioning

confidence: 99%

The role of natural killer cells in pulmonary immunosurveillance

Hesker

Krupnick²

2013

Front Biosci

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Natural killer (NK) cells were originally identified as lymphocytes capable of killing cancer cells without prior sensitization (1). Further characterization of these cells in both humans and rodent models has expanded their role towards a broad-based immunosurveillance of diseased and healthy peripheral tissues. Among peripheral organs, the lung contains the largest percentage of NK cells. Accordingly, NK cells are implicated in many immunological responses within the lung, including innate effector functions as well as initiation of the adaptive immune response. In this article, we review the characteristics of NK cells, current models of NK maturation and cell activation, migration of NKs to the lung, and effector functions of NKs in cancer and infection in the airways. Specific emphasis is placed on the functional significance of NKs in cancer immunosurveillance. Therapeutic modulation of NK cells appears to be a challenging but promising approach to limit cancer, inflammation, and infection in the lung.

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Section: The Role Of Nk Cells In Pulmonary Immunosurveillancementioning

confidence: 99%

The role of natural killer cells in pulmonary immunosurveillance

Hesker

Krupnick²

2013

Front Biosci

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Comparison of dose-dependent enhancing effects of ?-ray irradiation on urethan-induced lung tumorigenesis in athymic nude (nu/nu) mice and euthymic (nu/+) littermates

Kobayashi¹,

Otsu²,

Noda³

1996

J Cancer Res Clin Oncol

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The role of immunological surveillance in carcinogenesis is still controversial. In our previous experiments, urethan-induced lung tumorigenesis in athymic (nu/nu) mice and euthymic (nu/+) littermates was examined, and it was concluded that immunosurveillance mediated by T cells could not be demonstrated. However, the reported enhancement of development of various tumors following ionizing radiation might be achieved through modulating the host immunological conditions. In the present experiment, nu/nu and littermate nu/+ mice were treated with 1-4 Gy gamma-rays alone at 6 weeks of age or treated with urethan at 0.5 mg/g body weight when aged 14 days followed by 1-4 GY gamma-rays 4 weeks later. Lung tumors were assessed at 6.5 months of age. Ionizing radiation itself caused a very low incidence of these lesions. On the other hand, multiplicities and incidences of lung tumors after urethan treatment at 0.5 mg/g body weight were similar between the two phenotypically different groups of mice (1.66 and 1.84 tumors/mouse, 73% and 80% incidences, for nu/nu and nu/+ cases respectively). This urethan-induced lung tumorigenesis was significantly enhanced by gamma-rays in both nu/nu and nu/+ mice, and the magnitude of tumor enhancement was somewhat higher in nu/+ mice than in nu/nu mice, especially with a 2-Gy dose. In conclusion, it may be said that lung tumorigenicity of gamma-ray irradiation itself and the enhancing effect of radiation on urethan-induced tumorigenesis are scarcely influenced by immunosurveillance mechanisms mediated by T cells.

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Comparison of Lung Tumorigenesis Induced by Urethan in Athymic Nude Mice and Euthymic Littermates

Cited by 2 publications

References 20 publications

The role of natural killer cells in pulmonary immunosurveillance

The role of natural killer cells in pulmonary immunosurveillance

Comparison of dose-dependent enhancing effects of ?-ray irradiation on urethan-induced lung tumorigenesis in athymic nude (nu/nu) mice and euthymic (nu/+) littermates

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