Increased susceptibility to seizures and decreased catecholamine turnover in spontaneously hypertensive rats

Goldberg, M. E.; Milmore, John E.; Haubrich, Margaret; Haubrich, Dean R.

doi:10.1016/0014-2999(75)90184-3

Cited by 16 publications

(2 citation statements)

References 8 publications

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“…Epilepsy often co-exists with ADHD and autism (Canitano 2007; Deonna and Roulet 2006; Gurrieri and others 1999; Hamoda and others 2009; Hesdorffer and others 2004). SHR rats also have increased susceptibility to seizures (Goldberg and others 1975), but we do not know whether WKY/NCrl rats are susceptible to seizures.…”

Section: Discussionmentioning

confidence: 99%

SLC9A9 mutations, gene expression, and protein–protein interactions in rat models of attention‐deficit/hyperactivity disorder

Zhang-James

DasBanerjee

Sagvolden

et al. 2011

American J of Med Genetics Pt B

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SLC9A9 (solute carrier family 9, member 9, also known as Na+/H+ exchanger member (NHE9)) is a membrane protein that regulates the luminal pH of the recycling endosome, an essential organelle for synaptic transmission and plasticity. SLC9A9 has been implicated in human attention deficit hyperactivity disorder (ADHD) and in rat studies of hyperactivity. We examined the SLC9A9 gene sequence and expression profile in prefrontal cortex, dorsal striatum and hippocampus in two genetic rat models of ADHD. We report two mutations in a rat model of inattentive ADHD, the WKY/NCrl rat, which affect the interaction of SLC9A9 with calcineurin homologous protein (CHP). We observed an age-dependent abnormal expression of SLC9A9 in brains of this inattentive model and in the Spontaneous Hypertensive Rat (SHR) model of ADHD. Our data suggest a novel mechanism whereby SLC9A9 sequence variants and abnormalities in gene expression could contribute to the ADHD-like symptoms of rat models and possibly the pathophysiology of ADHD in humans.

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Section: Discussionmentioning

confidence: 99%

SLC9A9 mutations, gene expression, and protein–protein interactions in rat models of attention‐deficit/hyperactivity disorder

Zhang-James

DasBanerjee

Sagvolden

et al. 2011

American J of Med Genetics Pt B

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“…Experimental data have shown abnormality of the hippocampal structure, neurochemistry and behavior in SHRs [12][13][14] . Preclinical data showing seizure susceptibility of SHRs in animal models are few [15,16] . In chronic models of epilepsy, SHRs are reported to have lower seizure threshold than WKY rats in amygdala and piriform kindling [16] .…”

Section: Expert Hypothesismentioning

confidence: 99%

Finding a model for comorbidity between attention deficit hyperactivity disorder and epilepsy

2014

Mol Cell Epilepsy

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Close relationships between attention deficit hyperactivity disorder (ADHD) and epilepsy has been suggested due to prevalence of ADHD symptoms among patients with epilepsy than in the general population. Like epilepsy-depression connection, bi-directional relationships are suggested to underlie the predisposition of patients with ADHD to epilepsy and vice versa. Spontaneously hypertensive rats (SHRs) are characterized with typical behavioral symptoms such as hyperactivity, an attention deficit and impulsiveness, deficient sustained attention and decreased monoamine functioning. Our experimental findings suggest that SHRs might be used as a relevant model of comorbidity between ADHD and epilepsy. Spontaneously hypertensive rats demonstrate abnormal electrophysiological and behavioral characteristics as well as monoamine deficit in the frontal cortex and the hippocampus, which are also evident in epileptic rats. In addition, SHRs shows higher seizure susceptibility in models of temporal lobe epilepsy and disturbed circadian rhythms. Taken together, experimental findings suggest that SHRs could be used to explore the mechanism underlying bi-directional link of ADHD and epilepsy and as a screening method for mechanism-driven therapeutic approaches.

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Brain Edema and Blood Pressure Measurements in Unanesthetized Hypertensive Rats with Cortical Lesions

Nelson

Dick

Buñag

1976

Dynamics of Brain Edema

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Increased susceptibility to seizures and decreased catecholamine turnover in spontaneously hypertensive rats

Cited by 16 publications

References 8 publications

SLC9A9 mutations, gene expression, and protein–protein interactions in rat models of attention‐deficit/hyperactivity disorder

SLC9A9 mutations, gene expression, and protein–protein interactions in rat models of attention‐deficit/hyperactivity disorder

Finding a model for comorbidity between attention deficit hyperactivity disorder and epilepsy

Brain Edema and Blood Pressure Measurements in Unanesthetized Hypertensive Rats with Cortical Lesions

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