Brain Edema and Blood Pressure Measurements in Unanesthetized Hypertensive Rats with Cortical Lesions

Hypertension and brain oedema: an experimental study on acute and chronic hypertension in the rat.

“…With an immunoelectrophoretic technique, the amount of endogenous serum albumin [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] minutes after bicuculline administration has been found to be 200-300 ng/mg brain tissue (wet weight) in the diencephalon and mesencephalon and 60-220 ng/mg in the cortex.22 This amount of albumin would per se have a minor influence on the osmotic pressure of the extracellular fluid, and the effect on brain water will largely be determined by concomitant changes in electrolytes. No direct comparison can be made between the larger protein extravasation in acute hypertension and the smaller but supposedly more longlasting leakage in renal hypertension since the clearance rate of albumin from the tissue is not known.…”