Increased sodium appetite and polydipsia induced by partial aortic occlusion in the rat.

Costales, M.; Fitzsimons, J. T.; Vijande, M.

doi:10.1113/jphysiol.1984.sp015303

Cited by 26 publications

(9 citation statements)

References 16 publications

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“…For example, NaCl acceptance in some hypertensive models is increased (1,5,9,10,14,17,20,28), but in the other models it is decreased (14,15) or is unchanged (10,17). Consistent with these earlier studies, our data suggest that fluid acceptance is not a simple function of blood pressure.…”

Section: Discussionsupporting

confidence: 89%

“…In experimental models of arterial hypertension in rats, changes in consumption of water (9,14,16), sodium (1,5,9,10,12,14,15,17,20,28), potassium (1,12,15,20) and calcium (1,11,28) salts are found, but these changes are specific to particular models. For example, NaCl acceptance in some hypertensive models is increased (1,5,9,10,14,17,20,28), but in the other models it is decreased (14,15) or is unchanged (10,17).…”

Section: Discussionmentioning

confidence: 99%

“…Hypertension; Hypotension; Mice; Taste Preference; NaCl; KCl; CaCl 2 ; Bitter ARTERIAL hypertension in various rat models is often accompanied by changes in voluntary consumption of water and electrolytes (1,5,(9)(10)(11)(12)(13)(14)(15)(16)(17)20,28,33). In the mouse, three inbred strains differing in blood pressure have been produced by selective breeding: hypertensive BPH/2 (BPH), normotensive BPN/3 (BPN) and hypotensive BPL/1 (BPL) strains (25).…”

Section: Introductionmentioning

confidence: 99%

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Consumption of electrolytes and quinine by mouse strains with different blood pressures1

Bachmanov

Schlager

Tordoff

et al. 1998

Physiology & Behavior

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Daily fluid intakes were measured using two-bottle tests in female mice of inbred strains with high (BPH/2), normal (BPN/3) or low (BPL/1) blood pressure. The mice were offered a choice between water and different concentrations of NaCl (37.5-600 mM), KCl (1-400 mM), CaCl 2 (1-100 mM) and quinine hydrochloride (0.003-1.0 mM). Compared with the normotensive strain, the hypertensive mice had higher water and total fluid intakes, and lower intakes of NaCl, KCl (only 200 mM) and quinine; the hypotensive mice had higher intakes of KCl (only 10-50 mM) and lower intakes of CaCl 2 and quinine. These data suggest that fluid and salt intake are not linearly related to blood pressure, but are independently determined in these strains. Certain concentrations of the salts were preferred relative to water, which depended on mouse genotype: the BPN/3 and BPL/1 mice strongly preferred 37.5-150 mM NaCl, the BPL/1 mice preferred 10-100 mM KCl, and the BPN/3 mice preferred 1-10 mM CaCl 2 . KeywordsHypertension; Hypotension; Mice; Taste Preference; NaCl; KCl; CaCl 2 ; Bitter ARTERIAL hypertension in various rat models is often accompanied by changes in voluntary consumption of water and electrolytes (1,5,(9)(10)(11)(12)(13)(14)(15)(16)(17)20,28,33). In the mouse, three inbred strains differing in blood pressure have been produced by selective breeding: hypertensive BPH/2 (BPH), normotensive BPN/3 (BPN) and hypotensive BPL/1 (BPL) strains (25). However consumption of water or electrolytes has not been studied in these mice. Here, we compared water intake and acceptance of NaCl, KCl and CaCl 2 by the BPH, BPN and BPL mice. Because KCl and CaCl 2 have a bitter taste to humans and probably other animals (6,22,30), we also tested the mice with quinine hydrochloride in order to probe whether strain differences in bitter taste sensitivity affect KCl and CaCl 2 acceptance. METHOD SubjectsFemale mice of the BPH (n = 18), BPN (n = 20) and BPL (n = 16) strains were bred at the University of Kansas and shipped to the Monell Chemical Senses Center. The mice were 5- Measurement of Fluid IntakeFluid intake was measured using two-bottle preference tests of individually caged mice. Construction of drinking tubes and other experimental details have been previously described (2). The drinking tubes were positioned to the right of the feeder with their tips 15 mm apart, and each extended 25 mm into the cage. Each tube had a stainless steel tip with a 3.175-mm diameter hole from which the mice could lick fluids.Solutions of 37.5, 75, 150, 300, 450 and 600 mM NaCl, 1, 10, 50, 100, 200 and 400 mM KCl, 1, 10, 30 and 100 mM CaCl 2 , and 0.003, 0.01, 0.03, 0.1, 0.3 and 1.0 mM quinine hydrochloride (Sigma Chemical Co.) were prepared in deionized water. The mice were presented with one tube containing a solution and the other tube containing deionized water. The positions of the tubes were switched every 24 h in order to control for side preferences. Daily measurements were made in the middle of the light period by reading fluid volume to the neares...

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Consumption of electrolytes and quinine by mouse strains with different blood pressures1

Bachmanov

Schlager

Tordoff

et al. 1998

Physiology & Behavior

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“…Hyper-reninaemia also occurs in the two-kidney Goldblatt preparation produced by ligating the abdominal aorta between the renal arteries (Rojo-Ortega & Genest, 1968). This causes polydipsia and increased sodium appetite which can be reduced by large doses of captopril (Costales, Fitzsimons & Vijande, 1984).…”

Section: Discussionmentioning

confidence: 99%

The effect of captopril on sodium appetite in adrenalectomized and deoxycorticosterone‐treated rats.

Elfont¹,

Fitzsimons²

1985

The Journal of Physiology

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Captopril caused a renin-dependent increase in water intake in rats with bilateral ureteric ligation. But despite the fluid retention and fall in osmolality caused by the increased water intake, rats with ureteric ligation did not drink the 2.7% NaCl also offered to them. In rats with a pre-existing increase in sodium appetite caused by adrenalectomy, low dosage of captopril augmented intake of both water and 2.7% NaCl whereas high dosage inhibited intake of both fluids after an initial increase in water intake. In contrast, rats with a pre-existing increase in sodium appetite caused by daily injections of deoxycorticosterone showed no changes in intake of water or 2.7% NaCl after either low or high dosage of captopril, though they drank both fluids after intracranial injection of angiotensin II. Increases in water and 2.7% NaCl intake caused by low dosage of captopril in adrenalectomized rats were not secondary to increased urinary fluid and electrolyte losses. Decreases in intake after high dosage were not explained by the rats being too weak to drink. Low and high dosage of captopril caused increases in plasma renin concentration in adrenalectomized rats, but in contrast renin remained undetectable in the plasma of deoxycorticosterone-treated rats after the highest dosage of captopril. Whether or not captopril affected a pre-existing sodium appetite depended on whether or not it increased plasma renin. Since it affected the pre-existing sodium appetite and plasma renin in the adrenalectomized rat but neither of these in the deoxycorticosterone-treated rat, it is likely that the appetite was renin-dependent in the former but not in the latter. Because captopril only affected thirst in the rat with ligated ureters whereas it affected both sodium appetite and thirst in the adrenalectomized rat, increases in renal renin secretion alone may not be enough to stimulate sodium appetite. The additional stimulus provided by adrenalectomy, or the absence of some inhibitory factor that may be present after ureteric ligation, is also needed.

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“…High doses of captopril, on the other hand, decrease the Na intake of hypertensive (Di Nicolantonio et al 1982;Costales et al 1984), Na-deplete (Moe et al 1984) or adrenalectomized rats (Elfont & Fitzsimons 1981.…”

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confidence: 98%

THE EFFECT OF CAPTOPRIL OR ENALAPRILIC ACID ON THE Na APPETITE OF Na‐DEPLETE RATS

Weisinger

Denton

Nicolantonio

1988

Clin Exp Pharma Physio

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1. The converting enzyme inhibitors, captopril (SQ14 225, Squibb) or enalaprilic acid (MK 422, Merck Sharp and Dohme), were used to evaluate the role of angiotensin II in sodium (Na) appetite of Na-deplete rats given a choice of water and 0.5 mol/l NaCl to drink. Also, the effect of these drugs on taste was evaluated in water-deprived Na-replete rats and in Na-deplete rats given a choice of NaCl, sucrose and water. 2. Intraperitoneal (i.p.) injection of furosemide (20 mg/kg) increased urinary Na loss by 1.3-1.4 mmol and subsequent Na intake by 1.5-1.8 mmol. This increase in Na intake was abolished by a high dose of captopril (50 mg/kg, i.p.) or enalaprilic acid (80 mg/kg, i.p.), but was enhanced by a low dose of captopril (50 micrograms/kg, i.p.). 3. There was no clear evidence that either captopril or enalapril affected taste for NaCl, sucrose or water in water-deprived Na-replete rats. However, the high dose of captopril or enalapril decreased the intake of NaCl and sucrose in Na-deplete rats. 4. Thus, while the results are consistent with the possibility that angiotensin II is involved in Na appetite induced by Na depletion and that the difference between the high and low doses of converting enzyme inhibitors on Na appetite may be related to their relative effectiveness in blocking angiotensin I conversion at central sites, the observation that sucrose intake is decreased by high dose converting enzyme inhibitor in Na-deplete rats suggests that other actions of the converting enzyme inhibitors may be involved.

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Increased sodium appetite and polydipsia induced by partial aortic occlusion in the rat.

Cited by 26 publications

References 16 publications

Consumption of electrolytes and quinine by mouse strains with different blood pressures1

Consumption of electrolytes and quinine by mouse strains with different blood pressures1

The effect of captopril on sodium appetite in adrenalectomized and deoxycorticosterone‐treated rats.

THE EFFECT OF CAPTOPRIL OR ENALAPRILIC ACID ON THE Na APPETITE OF Na‐DEPLETE RATS

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