Increased skeletal muscle expression of VEGF induced by massage and exercise

Andrzejewski, Waldemar; Kassolik, Krzysztof; Kobierzycki, Christopher; Grzegrzółka, Jędrzej; Ratajczak‐Wielgomas, Katarzyna; Jabłońska, Karolina; Halski, Tomasz; Dzięgiel, Piotr; Gworys, Bohdan; Podhorska-Okołów, Marzena

doi:10.5603/fhc.a2015.0013

Cited by 14 publications

(16 citation statements)

References 20 publications

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“…So far, there are only reports suggesting significant importance of NPWT in supporting the treatment of infected wounds; however, there are no data on the effects of NPWT on the process of proangiogenic factors stimulation. Comparable to the results of our previous studies regarding the effect of massage on tendinous and muscle tissue in rats [15,16], Xia et al [19] showed increased expression of VEGF-A, EGF and PDGF at the protein level in the group of patients subjected to NPWT in the third day following the use of this therapy, relative to the patients who were not subjected to NPWT. The authors suggested that NPWT, as one of the forms of physiotherapy, may affect the local expression of angiogenesis-associated growth factors, which is also in line with the tendency observed in our studies.…”

Section: Discussionsupporting

confidence: 60%

“…Our earlier publications showed that massage of tendons and skeletal muscles in rats, applied during long-term, repeated, intensive physical activity, has stimulatory effect on angiogenesis within the massaged tissues [15,16]. Those studies show reliable arguments for the application of massage in order to improve the function of tendons and skeletal muscles, both in prophylactic and therapeutic treatment, as well as an element of biological recovery in sportsmen.…”

Section: Introductionmentioning

confidence: 92%

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Effects of massage on the expression of proangiogenic markers in rat skin

Ratajczak‐Wielgomas

Kassolik

Grzegrzółka

et al. 2018

Folia Histochem Cytobiol.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 92%

Effects of massage on the expression of proangiogenic markers in rat skin

Ratajczak‐Wielgomas

Kassolik

Grzegrzółka

et al. 2018

Folia Histochem Cytobiol.

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“…Antibodies used were Anti-PGC-1α Mouse mAb (4C1.3) (ST1202) and Anti-VEGF (Ab-3) Mouse mAb (14–124) (GF25) (Merck Millipore). Results are presented as ratios of VEGF or PGC-1α expression to a loading control, beta Actin (ab8227) (Abcam), ensuring equal loading on the gel (Ruas et al, 2012; Andrzejewski et al, 2015). Also, gel-to-gel variation was adjusted for using an internal standard.…”

Section: Methodsmentioning

confidence: 99%

No Additional Benefits of Block- Over Evenly-Distributed High-Intensity Interval Training within a Polarized Microcycle

et al. 2017

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Introduction: The current study aimed to investigate the responses to block- versus evenly-distributed high-intensity interval training (HIT) within a polarized microcycle.Methods: Twenty well-trained junior cross-country skiers (10 males, age 17.6 ± 1.5 and 10 females, age 17.3 ± 1.5) completed two, 3-week periods of training (EVEN and BLOCK) in a randomized, crossover-design study. In EVEN, 3 HIT sessions (5 × 4-min of diagonal-stride roller-skiing) were completed at a maximal sustainable intensity each week while low-intensity training (LIT) was distributed evenly around the HIT. In BLOCK, the same 9 HIT sessions were completed in the second week while only LIT was completed in the first and third weeks. Heart rate (HR), session ratings of perceived exertion (sRPE), and perceived recovery (pREC) were recorded for all HIT and LIT sessions, while distance covered was recorded for each HIT interval. The recovery-stress questionnaire for athletes (RESTQ-Sport) was completed weekly. Before and after EVEN and BLOCK, resting saliva and muscle samples were collected and an incremental test and 600-m time-trial (TT) were completed.Results: Pre- to post-testing revealed no significant differences between EVEN and BLOCK for changes in resting salivary cortisol, testosterone, or IgA, or for changes in muscle capillary density, fiber area, fiber composition, enzyme activity (CS, HAD, and PFK) or the protein content of VEGF or PGC-1α. Neither were any differences observed in the changes in skiing economy, trueV˙O2max or 600-m time-trial performance between interventions. These findings were coupled with no significant differences between EVEN and BLOCK for distance covered during HIT, summated HR zone scores, total sRPE training load, overall pREC or overall recovery-stress state. However, 600-m TT performance improved from pre- to post-training, irrespective of intervention (P = 0.003), and a number of hormonal and muscle biopsy markers were also significantly altered post-training (P < 0.05).Discussion: The current study shows that well-trained junior cross-country skiers are able to complete 9 HIT sessions within 1 week without compromising total work done and without experiencing greater stress or reduced recovery over a 3-week polarized microcycle. However, the findings do not support block-distributed HIT as a superior method to a more even distribution of HIT in terms of enhancing physiological or performance adaptions.

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“…Because we do not know which modality was effective, and because clinical manual therapy research is plagued by lack of consensus regarding sham treatments (Chaibi, Saltyte Benth et al 2015), we chose to have a control group that was held only, and not otherwise actively treated. Further research is planned to address these challenging questions, as well as possible changes in angiogenesis and vascular function reported to occur with massage therapy (Andrzejewski, Kassolik et al 2014, Franklin, Ali et al 2014, Andrzejewski, Kassolik et al 2015). …”

Section: Study Limitationsmentioning

confidence: 99%

Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury

Bove

Harris

Zhao

et al. 2016

Journal of the Neurological Sciences

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Key clinical features of carpal tunnel syndrome and other types of cumulative trauma disorders of the hand and wrist include pain and functional disabilities. Mechanistic details remain under investigation but may involve tissue inflammation and/or fibrosis. We examined the effectiveness of modeled manual therapy (MMT) as a treatment for sensorimotor behavior declines and increased fibrogenic processes occurring in forearm tissues of rats performing an high repetition high force (HRHF) reaching and grasping task for 12 weeks. Young adult, female rats were examined: food restricted control rats (FRC, n=12); rats that were trained for 6 weeks before performing the HRHF task for 12 weeks with no treatment (HRHF-CON, n=11); and HRHF task rats received modeled manual therapy (HRHF-MMT, n=5) for 5 days/week for the duration of the 12-week of task. Rats receiving the MMT expressed fewer discomfort-related behaviors, and performed progressively better in the HRHF task. Grip strength, while decreased after training, improved following MMT. Fibrotic nerve and connective tissue changes (increased collagen and TGF-β1 deposition) present in 12-week HRHF-CON rats were significantly decreased in 12-week HRHF-MMT rats. These observations support the investigation of manual therapy as a preventative for repetitive motion disorders.

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Increased skeletal muscle expression of VEGF induced by massage and exercise

Cited by 14 publications

References 20 publications

Effects of massage on the expression of proangiogenic markers in rat skin

Effects of massage on the expression of proangiogenic markers in rat skin

No Additional Benefits of Block- Over Evenly-Distributed High-Intensity Interval Training within a Polarized Microcycle

Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury

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