Increased Serum Levels of TNF-Α and IL-6 are not Related to HLA-Cw6 in Psoriasis Patients Correlation of Cytokine with HLA Cw6

Abstract

Psoriasis is a T cell mediated inflammatory skin disease. Complex network of cytokine induces and maintain the psoriatic lesion. Study was performed to evaluate the correlation between the level of TNF-α and IL-6, in the psoriasis patients with HLA-Cw6. Cytokine levels were assayed by sandwich ELISA and HLA-Cw6 typing was done by microcytoxicity method. Serum TNF-α and IL-6 were significantly (p=<0.001 in both) expressed in psoriasis patients. TNF-α had significant positive correlation with IL-6 (p=0.56, p=<0.001). We can conclude that TNF-α and IL-6 are found elevated in serum in psoriasis patients, compared to the control group. Proinflammatory cytokine such as TNF-α and IL-6 may cause inflammatory changes in microenvironment of psoriasis lesion. Gender of patient and age on onset of disease does not influence the expression of these cytokine in psoriasis cases. Results suggest that HLA-Cw6 did not influence these cytokines secretion.