Increased serum free IgE levels in patients with chronic spontaneous urticaria (CSU)☆

Jang, Jae-Hyuk; Yang, Eun‐Mi; Lee, Youngsoo; Ye, Young-Min; Moon, Ji-Young; Ryu, Min Sook; Park, Hae‐Sim

doi:10.1016/j.waojou.2022.100629

Cited by 8 publications

(7 citation statements)

References 52 publications

(66 reference statements)

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“…The obtained results generally agreed with Góra et al [15]mentioned the parameters (WBC,EO,IgE,IL-6 ) higher in patient with acute and chronic urticarial than control group , as well as agreed with Jang et al [16] the serum IgE higher in the patients IgE modulates mast cell activation and releases histamine, lipid mediators, kinins, and cytokines, which contributes to the development and severity of CSU by interacting with a high-affinity IgE receptor (FcRI) found on cutaneous mast cells and basophils [17].…”

Section: Biomarkers Between Csu Patients and Control Subjectsupporting

confidence: 90%

Evaluation of IL-6 and IgE Levels in Iraqi Patients with Chronic Spontaneous Urticaria (CSU) in Baghdad, Iraq.

Ahmed

Hussein

Brakhas

2023

IHJPAS

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A skin condition known as chronic spontaneous urticaria (CSU), which lacks an obvious triggering factor, is characterized by recurrent transient wheals, angioedema, or both for longer than six weeks. the current study was focused to study compared and diagnosis CSU by using heamatological and immunological parameters as (White blood cell count, eosinophils (EO), IL-6 and Total-IgE, in Chronic Urticaria patients were Clinically diagnosed by dermatologists in Specialized Center of Allergy in Baghdad/Al-Rusafa with age ranged between (11-60), as well as a control group included 40 with age ranged between (11-60). The results of demographic and clinical characteristics displayed the rate of female patients was higher than male which represented by 56.3 and 43.8% respectively. The results showed there was highly significant differences between the patients and the control in WBC , Total-IgE ,IL-6 the results showed EO was higher than control but no significant difference at p ≤ 0.05. The eosinophils percentage was high in age 51-60 and 21-30 year while those with age 41-50 and 51-60 year had highest, Total-IgE level 211.7 ±38.96 IU/ml, 211.69 ±38.71IU/ml respectively but IL-6 level was highest 26.4 ±1.77 pg/ml in patients with age group 21-30 year. WBC count in age 41-50 and 51-60 year showed highest count 9.2 ±1.34 cell/cm³blood, 9.3±1.21 cell/cm³blood respectively. In same time the values of parameters were various between patients without treatment and in patients who undergoes into treatment, Finally The ROC showed the IL-6 and Total-IgE were discriminated as accurate biomarkers for CSU.

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Section: Biomarkers Between Csu Patients and Control Subjectsupporting

confidence: 90%

Evaluation of IL-6 and IgE Levels in Iraqi Patients with Chronic Spontaneous Urticaria (CSU) in Baghdad, Iraq.

Ahmed

Hussein

Brakhas

2023

IHJPAS

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“…11 Typical examples of type-1 hypersensitivity include urticaria, asthma, and allergic rhinitis, in which serum IgE increases could be found. 12–14 In patients with ACDs, both serum total and specific IgE levels were found to be higher than those in healthy subjects. 15,16 However, the invasive nature of these testing methods limits their large-scale use in the diagnosis of ACDs.…”

Section: Discussionmentioning

confidence: 97%

Novel Application of Immunochromatographic Assay for Measurement of Total Tear Immunoglobulin E

Liu

Wang

et al. 2023

Cornea

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Purpose:The aim of this study was to evaluate the efficacy of a new immunochromatographic assay (Aifeice) in the diagnosis of allergic conjunctivitis diseases (ACDs) and to explore the relationship between Aifeice testing results and the severity of ACDs.Methods:A multicenter prospective cross-sectional study (390 patients diagnosed with ACDs and 619 healthy controls) was conducted. Patients with ACDs were scored based on clinical symptoms. All participants received the Aifeice test. The positive testing results were further divided into 3 immunoglobulin E (IgE) grades. Statistical analysis was performed to evaluate the indexes associated with the testing results.Results:The sensitivity, specificity, positive predictive value, negative predictive value, and total coincidence rate of the Aifeice test were 96.15%, 98.87%, 98.17%, 97.61%, and 97.82%, respectively. The total clinical score was significantly correlated with the IgE grade. The factors that affected the IgE score were conjunctival hyperemia, conjunctival swelling, conjunctival papillae, and Horner–Trantas dots.Conclusions:The high sensitivity and specificity of Aifeice in the diagnosis of ACD was confirmed. This new immunochromatographic assay could be used to assess the severity of ACD.

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“…Patients with CSU with atopy had significantly higher serum free IgE levels than those without atopy ( 67 ), while no associations were noted with UAS, urticaria duration, or response to omalizumab. However, patients with elevated levels of Der p-specific IgE and its ratio to the level of serum total free IgE have favorable responses to omalizumab ( 67 ). Therefore, the clinical relationship between serum-free IgE levels and CSU requires further confirmation.…”

Section: High Total Ige and Its Clinical Relevance In Cumentioning

confidence: 91%

“…( 67 ) recently developed a novel assay to measure serum-free IgE levels in patients with CSU. Patients with CSU with atopy had significantly higher serum free IgE levels than those without atopy ( 67 ), while no associations were noted with UAS, urticaria duration, or response to omalizumab. However, patients with elevated levels of Der p-specific IgE and its ratio to the level of serum total free IgE have favorable responses to omalizumab ( 67 ).…”

Section: High Total Ige and Its Clinical Relevance In Cumentioning

confidence: 99%

“…Serum-free IgE levels are more predictive of atopic status than total IgE levels (46). Jang et al (67) recently developed a novel assay to measure serum-free IgE levels in patients with CSU. Patients with CSU with atopy had significantly higher serum free IgE levels than those without atopy (67), while no associations were noted with UAS, urticaria duration, or response to omalizumab.…”

Section: High Total Ige and Its Clinical Relevance In Cumentioning

confidence: 99%

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Atopy in chronic urticaria: an important yet overlooked issue

Chen,

Yang,

et al. 2024

Front. Immunol.

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Chronic urticaria (CU) is one of the most common dermatological diseases and has a significant impact on the quality of life of patients. However, the pathogenesis of this disease remains unclear. Autoimmunity in chronic spontaneous urticaria (CSU) has received considerable attention and has been studied previously. Atopy is an important characteristic of CU; however, it has not been fully recognized. Atopy predisposes individuals to immune responses to allergens, leading to type 2 inflammation and immunoglobulin E (IgE) overproduction. Compared with healthy individuals, patients with CU have a higher proportion of atopy, and an atopic background is correlated with the clinical characteristics of CU. The total IgE levels in patients with CU is significantly higher than those in healthy individuals. Although its level is not higher than that in classic allergic diseases, it is closely related to CU. Exogenous allergens, auto-allergens, and specific IgEs, which are closely related to atopy, have been reported, and their roles in CU pathogenesis are also being studied. Local and systemic atopic inflammation is present in patients with CU. This review summarizes the current knowledge regarding atopy and CU, speculating that there are CU subtypes, such as atopic CSU or atopic chronic inducible urticaria (CIndU) and that atopy may be involved in the pathogenesis of CU. These findings provide a new perspective for a comprehensive understanding of the clinical features of CU and further research regarding its pathogenesis.

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Increased serum free IgE levels in patients with chronic spontaneous urticaria (CSU)☆

Cited by 8 publications

References 52 publications

Evaluation of IL-6 and IgE Levels in Iraqi Patients with Chronic Spontaneous Urticaria (CSU) in Baghdad, Iraq.

Evaluation of IL-6 and IgE Levels in Iraqi Patients with Chronic Spontaneous Urticaria (CSU) in Baghdad, Iraq.

Novel Application of Immunochromatographic Assay for Measurement of Total Tear Immunoglobulin E

Atopy in chronic urticaria: an important yet overlooked issue

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