Increased serum concentrations of procollagen type III peptide in severely injured patients

Waydhas, Christian; Nast-Kolb, D.; Trupka, A.; Lenk, Susann; Duswald, Karl-Heimo; Schweiberer, L.; Jochum, Marianne

doi:10.1097/00003246-199302000-00016

Cited by 26 publications

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“…Higher levels in plasma of patients with ALI/ARDS have also been reported in a few small studies 53,54 . In one study of 57 patients with severe trauma, elevated PCPIII levels were associated with higher mortality, longer duration of mechanical ventilation and poorer oxygenation 55 . The finding of elevated plasma PCPIII levels in trauma patients with ALI/ARDS supports the hypothesis that lung fibrosis is triggered early in the course of ALI/ARDS.…”

Section: Discussionmentioning

confidence: 99%

“…The finding of elevated plasma PCPIII levels in trauma patients with ALI/ARDS supports the hypothesis that lung fibrosis is triggered early in the course of ALI/ARDS. However, it should be noted that increased PCPIII levels in trauma patients may also reflect wound healing, fibrosis in other organs and decreased clearance due to hepatic dysfunction 55 .…”

Section: Discussionmentioning

confidence: 99%

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Acute Lung Injury in Patients With Traumatic Injuries: Utility of a Panel of Biomarkers for Diagnosis and Pathogenesis

Fremont

Koyama

Calfee

et al. 2010

Journal of Trauma: Injury, Infection &Amp; Critical Care

155

141

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Background The diagnosis of acute lung injury (ALI) is based on a consensus clinical definition. Despite the simplicity of this definition, ALI remains underdiagnosed and undertreated. Severe trauma is a well-described cause of ALI that represents a relatively homogeneous subset of ALI patients. The goals of this study were to develop a panel of plasma biomarkers to facilitate diagnosis of trauma-induced ALI and to enhance our understanding of the pathogenesis of human ALI. Methods A retrospective nested case control of 192 patients admitted to the trauma intensive care unit (ICU) at a university hospital between 2002 and 2006. We compared 107 patients with ALI to 85 patients without ALI. Plasma was collected within 72 h of ICU admission. Twenty-one plasma biomarkers were measured in duplicate in each plasma sample. Results Patients with ALI had higher severity of illness scores, more days of mechanical ventilation, longer hospital stays and higher mortality versus controls. Seven biomarkers (RAGE, PCPIII, BNP, ANG2, IL10, TNF-α, and IL8) had a high diagnostic accuracy as reflected by the area under the receiver operating characteristic curve of 0.86 (95% CI 0.82 – 0.92) in differentiating ALI from controls. Conclusions A model utilizing seven plasma biomarkers had a high diagnostic accuracy in differentiating patients with trauma-induced ALI from trauma patients without ALI. In addition, use of a panel of biomarkers provides insight into the likely importance of alveolar epithelial injury in the pathogenesis of early acute lung injury.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute Lung Injury in Patients With Traumatic Injuries: Utility of a Panel of Biomarkers for Diagnosis and Pathogenesis

Fremont

Koyama

Calfee

et al. 2010

Journal of Trauma: Injury, Infection &Amp; Critical Care

155

141

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“…In nonsurvivors, the collagen content of the lung is increased two-to threefold after 2 weeks of ARDS and parallels the development of fibrosis [7]. Patients with ARDS dying after 7 days of respiratory failure have, in contrast to survivors, persistent elevation of extracellular matrix components (procollagen III) in the BAL and serum, indicating ongoing fibrogenesis [77,[128][129][130]. Patients with a procollagen III level greater than 1.75 U·mL -1 in BAL on day 7 had a 72% mortality rate compared with a 20% mortality rate in patients with a procollagen III level less than 1.75 U·mL -1 [131].…”

Section: Fibroproliferationmentioning

confidence: 99%

The role of the host defence response in the progression and outcome of ARDS: pathophysiological correlations and response to glucocorticoid treatment

Gu¹

1996

Eur Respir J

114

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T Th he e r ro ol le e o of f t th he e h ho os st t d de ef fe en nc ce e r re es sp po on ns se e i in n t th he e p pr ro og gr re es ss si io on n a an nd d o ou ut tc co om me e o of f A AR RD DS S: : p pa at th ho op ph hy ys si io ol lo og gi ic ca al l c co or rr re el la at ti io on ns s a an nd d r re es sp po on ns se e t to o g gl lu uc co oc co or rt ti ic co oi id d t tr re ea at tm me en nt t

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“…The combined use of three serum biomarkers of hyaluronic acid (HA) [11], which is a component of the extracellular matrix (ECM) and is primarily cleared from the bloodstream by the hepatic sinusoids, tissue inhibitors of metalloproteinases (TIMP-1) [12]–[16] inhibiting the activities of matrix metalloproteinases (MMPs) and amino-terminal propeptide of procollagen type III (PIIINP) [17]–[20] reflecting collagen synthesis at the site of disease has recently been proposed for the detection of fibrosis. In clinical practice, serum samples were analysed for levels of HA, TIMP-1 and PIIINP.…”

Section: Introductionmentioning

confidence: 99%

The Performance of Enhanced Liver Fibrosis (ELF) Test for the Staging of Liver Fibrosis: A Meta-Analysis

et al. 2014

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BackgroundThe enhanced liver fibrosis test (ELF) has been shown to accurately predict significant liver fibrosis in several liver diseases.AimsTo perform a meta-analysis to assess the performance of the ELF test for the assessment of liver fibrosis.StudyElectronic and manual searches were performed to identify studies of the ELF test. After methodological quality assessment and data extraction, pooled estimates of the sensitivity, specificity, area under the receiver operating characteristic curve (AUROC), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and summary receiver operating characteristics (sROC) were assessed systematically. The extent of heterogeneity and reasons for it were assessed.ResultsNine studies were identified for analysis. The pooled sensitivity, specificity, positive LR, negative LR, and DOR values of ELF test, for assessment of significant liver fibrosis, were 83% (95% CI = 0.80–0.86), 73% (95% CI = 0.69–0.77), 4.00 (95% CI = 2.50–6.39), 0.24 (95% CI = 0.17–0.34), and 16.10 (95% CI = 8.27–31.34), respectively; and, for evaluation of severe liver fibrosis, were 78% (95% CI = 0.74–0.81), 76% (95% CI = 0.73–0.78), 4.39 (95% CI = 2.76–6.97), 0.27 (95% CI = 0.16–0.46), and 16.01 (95% CI: 7.15–35.82), respectively; and, for estimation of cirrhosis, were 80% (95% CI = 0.75–0.85), 71% (95% CI = 0.68–0.74), 3.13 (95% CI = 2.01–4.87), 0.29 (95% CI = 0.19–0.44), and 14.09 (95% CI: 5.43–36.59), respectively.ConclusionsThe ELF test shows good performance and considerable diagnostic value for the prediction of histological fibrosis stage.

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Increased serum concentrations of procollagen type III peptide in severely injured patients

Cited by 26 publications

References 0 publications

Acute Lung Injury in Patients With Traumatic Injuries: Utility of a Panel of Biomarkers for Diagnosis and Pathogenesis

Acute Lung Injury in Patients With Traumatic Injuries: Utility of a Panel of Biomarkers for Diagnosis and Pathogenesis

The role of the host defence response in the progression and outcome of ARDS: pathophysiological correlations and response to glucocorticoid treatment

The Performance of Enhanced Liver Fibrosis (ELF) Test for the Staging of Liver Fibrosis: A Meta-Analysis

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