Increased Serum Chemerin Levels in Diabetic Retinopathy of Type 2 Diabetic Patients

Du, Junhui; Li, Rong; Xu, Lin; Ma, Rong; Liu, Jiali; Cheng, Jing; Zhong, Zhang; Sun, Hongzhi

doi:10.3109/02713683.2015.1004718

Cited by 26 publications

(19 citation statements)

References 40 publications

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“…In this study, in vivo functional angiogenesis assays confirmed that chemerin significantly mediates the formation of blood vessels to a similar extent as that of VEGF. These results support the other reports, which show that the serum levels of chemerin and VEGF are significantly increased in the proliferative diabetic retinopathy and nonproliferative retinopathy patients (Du et al 2016). Figure 5.…”

Section: Discussionsupporting

confidence: 93%

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Chemerin promotes angiogenesis in vivo

et al. 2018

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Chemerin acts as a chemotactic factor for leukocyte populations expressing the G protein‐coupled receptor CMKLR1 (ChemR23). It is also an adipocytokine involved in obesity and metabolic syndromes. Previous studies have demonstrated that chemerin promotes angiogenesis in vitro, although the precise mechanism has not been elucidated. In this study, we have investigated whether chemerin regulates angiogenic processes and validated the associated mechanisms. In this study, chemerin stimulated angiogenesis in mice, which was demonstrated using Matrigel plug implantation assay, mouse corneal models of angiogenesis, and ex vivo rat aortic ring assay. To explore the mechanisms by which chemerin induced angiogenesis, we examined the effects of chemerin in human umbilical vein endothelium cells (HUVECs). Chemerin stimulated the differentiation of HUVECs into capillary‐like structures, promoted the proliferation of HUVECs, and functioned as a chemoattractant in migration assays. Chemerin induced the phosphorylation of Akt and p42/44 extracellular signal‐regulated kinase (ERK) in HUVECs and chemerin promotes angiogenesis via Akt and ERK. SiRNA against the chemerin receptor CMKLR1 but not that against another chemerin receptor, CCRL2, completely inhibited the chemerin‐induced migration and angiogenesis of HUVECs, which indicates that chemerin promotes the migration and angiogenic activities of HUVECs mainly through CMKLR1.

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Section: Discussionsupporting

confidence: 93%

“…These results support the other reports, which show that the serum levels of chemerin and VEGF are significantly increased in the proliferative diabetic retinopathy and nonproliferative retinopathy patients (Du et al. ).…”

Section: Discussionsupporting

confidence: 93%

Chemerin promotes angiogenesis in vivo

et al. 2018

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“…; Shin et al (24) ; Yoo et al (25) ; Sledzinski et al (26) ; Bobbert et al (27) and Du et al (28) detected a strong association between chemerin and obesity. These findings indicated that chemerin may play a role in obesity and the development of obesity comorbidities.…”

Section: Discussion:-mentioning

confidence: 94%

Serum levels of Chemerin and Omentin 1 in Obese Type 2 Diabetic Patients.

El-Shafae¹,

Issa²,

Behiry³

et al. 2016

IJAR

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Background:-. Peripheral insulin resistance is present in obese patients primarily due to the marked down regulation of the insulin receptors. Obesity is associated with elevated levels of chemerin that might influence dysregulation of glucose metabolism. Omentin-1 (Intelectin-1) is a newly identified protein that is highly and selectively expressed in visceral adipose tissue. Controversy has arisen concerning the regulatory mechanisms that modulate chemerin and omentin-1 expression and function, namely obesity, chronic inflammation, insulin resistance, or oxidative stress. Objectives:-The aim of this work is to estimate the serum levels of chemerin and omentin 1 in obese patients with type 2 diabetes mellitus and their correlation to disease progress and activity. Subjects and methods:-This prospective study was conducted on 80 individuals where 60 subjects were complaining of type 2 diabetes mellitus and 20 apparently healthy subjects serving as the control group. Individuals were subjected to full history taking, thorough clinical examination, anthropometric measurements, routine and specific laboratory investigations including glycated Hb, fasting insulin level, HOMA-IR, chemerin and omentin-1 serum levels. Results:-We found that there were statistically high significant differences between the studied groups regarding anthropometric measurements, DM duration, fasting blood sugar, glycated hemoglobin, lipid profile, liver function tests and chemerin and omentin, while there was significant differences regarding insulin and HOMA. We found statistically high significant positive correlations between chemerin and fasting blood sugar, glycated hemoglobin, lipid profile , liver enzymes, HOMA -IR and body mass index. There were statistically high significant negative correlations between omentin and fasting blood sugar, glycated hemoglobin, lipid profile, liver enzymes, HOMA -IR and body mass index, significant positive correlations regarding duration and insulin. Conclusion:-Chemerin levels were significantly increased in obese patients and were related to insulin resistance. Omentin-1 levels were decreased in morbid obesity (MO), were inversely associated with chronic inflammation and dyslipidemia and the main modulating factors seemed to be dyslipidemia, hyperglycemia and BMI.

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“…Serum levels of chemerin, a multifunctional peptide involved in lipid and glucose metabolism [45] has also been found to be elevated in patients with NPDR and PDR [46].…”

Section: Discussionmentioning

confidence: 99%

Serum Taurine Level in Relation to Ophthalmoscopic Examination as Early Marker for Diabetic Retinopathy

Saad¹,

Mahfouz²,

Hamdy³

2017

Clin Med Biochemistry

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Aim: Investigate the possibility of using serum taurine level in addition to ophthalmoscopic examination as early marker for diagnosis diabetic retinopathy.Patients and methods: eighty diabetic patients presented with blurring in vision were chosen from the National Institute of Diabetes and Endocrinology after their approval. Twenty healthy volunteers were enrolled as frank control. According to the image of ophthalmoscopic examination, patients were classified into four grades (mild, moderate, sever non-proliferative and proliferative) of retinopathy. Complete clinical examination, investigation and biochemical analysis, measuring FBG, HbA1c, VEGF and taurine were measured for all included subjects.Results: Non-significance change in LDL and triglycerides for all stages with respect to control group. HDL and cholesterol showed significant with frank group. Albumin and creatinine for some stages of retinopathy showed nonsignificance changes with respect to control group. Urea recorded significant in all grades when comparing with control group, all included patients showed either micro or macroalbuminurea. AST and ALT showed highly significant in late stage comparing with frank group. Serum VEGF significant for all stages with frank group. Highly significant elevation in FBG and serum HbA1c was found parallel to the severity of disease. Compared to healthy group, a highly significant decrease in the level of serum taurine was recorded in all patients. Such decrease was correlated the grading of retinopathy ranting from mild non-proliferative to proliferative. Conclusion:We advise measuring serum taurine level and ophthalmoscopic examination regularly for all persons with diabetes as a pre early marker for diabetic retinopathy.

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Increased Serum Chemerin Levels in Diabetic Retinopathy of Type 2 Diabetic Patients

Cited by 26 publications

References 40 publications

Chemerin promotes angiogenesis in vivo

Chemerin promotes angiogenesis in vivo

Serum levels of Chemerin and Omentin 1 in Obese Type 2 Diabetic Patients.

Serum Taurine Level in Relation to Ophthalmoscopic Examination as Early Marker for Diabetic Retinopathy

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