Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

Hung, Shun-Fa; Chung, Shiu-Dong; Kuo, Hann‐Chorng

doi:10.1371/journal.pone.0085588

Cited by 42 publications

(45 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, they did not make any comment in these regards. Hung et al (1) identified this situation in their study, but they could not clarify this issue and could not assert any hypothesis. Only the determination of the situation was made in both articles.…”

Section: Discussionmentioning

confidence: 79%

“…In their study, Hung et al (1) reported that serum CRP levels increase with age in the association of BPH and LUTS; besides, they identified a positive correlation between the filling symptoms and high LUTS values and the CRP. It may be asked though, why does CRP rise in patients with only high filling symptoms?…”

Section: Discussionmentioning

confidence: 91%

“…There are publications about the relationship between LUTS and CRP not being fully understood and this relationship has been found to be, conversely, both significant and insignificant in the studies conducted (1,5) results, this study was intended to be repeated in our hospital for the purpose of detecting the presence of the relationship. However, when our results were evaluated, it was observed that there was no relationship between LUTS positivity and CRP when both the quantitative and cut-off values were taken as 0.5 mg/dL.…”

Section: Discussionmentioning

confidence: 99%

“…When the V/S (Voiding/Storage) ratio is >1, in which chronic inflammation can be associated with LUTS, the interpretation of the presence of inflammation in the prostatic tissues is made (1). Serum CRP levels have been reported to show a positive correlation in patients who have LUTS with weighted symptoms of OAB (15).…”

Section: Discussionmentioning

confidence: 99%

“…C-reactive protein (CRP) is a widely used, inexpensive, and easily found biomarker for inflammation (1). Although the distribution of CRP levels changes at different rates, CRP is seen as a valuable tool in inflammation studies, and high-sensitive (hs) CRP has been applied lately along with the use of more accurate measurements; it provides more accurate and precise measurements (9, 10) but does not exist in every work environment.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Is There a Relationship between Lower Urinary Tract Symptoms and C-reactive Protein Levels in Men? A Cross-Sectional Study

Ayyıldız¹,

Ayyıldız²,

Benli̇³

et al. 2016

JAREM

View full text Add to dashboard Cite

Objective: Lower urinary tract symptoms (LUTSs) increase with benign prostatic hyperplasia and age in men. The mechanism underlying this increase is not well known. In literature, an increase in inflammation is suggested as the reason for LUTSs. C-reactive protein (CRP) is a commonly used and important marker for inflammation. The aim of this study was to question the relationship between LUTS and CRP levels and to determine if inflammation may cause LUTSs.Methods: Our study was retrospective and cross-sectional. One hundred and eighty-three patients who were LUTS (+) and (−) and who were suggested to undergo prostate biopsy because of high PSA were included in this study in a urology polyclinic. For all patients suggested to undergo biopsy, CRP levels were routinely requested by the polyclinic. CRP levels were compared to LUTSs both based on their value in the report and their cut-off value of 0.50 mg/dL. For statistical analyses, p<0.05 was considered significant.Results: While the average age in LUTS (+) patients was 62.71±0.87 years, in LUTS (−) patients, it was 61.67±1.01 years (p=0.625). When the CRP levels of the patients with and without symptoms were compared, a statistically significant difference was not found (p=0.189). Additionally, in the evaluation made, by considering pathological if the cut-off values of CRP were 0.5 mg/dL or more, there was no difference between LUTS (+) and (−) patients (p=0.921). Conclusion:In our study, we could not find a relationship between LUTSs and CRP levels. There are many factors affecting CRP levels. Currently, to determine the relationship between LUTSs and CRP levels, wider, community-based studies where all factors affecting CRP levels are excluded and containing sub-analyses are required. (JAREM 2016; 6: 105-9)

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Is There a Relationship between Lower Urinary Tract Symptoms and C-reactive Protein Levels in Men? A Cross-Sectional Study

Ayyıldız¹,

Ayyıldız²,

Benli̇³

et al. 2016

JAREM

View full text Add to dashboard Cite

show abstract

Serum C‐reactive protein level is not associated with prostatic inflammation but with overactive detrusor in patients with benign prostatic hyperplasia

Inamura

Ito

Shinagawa

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

Aim Chronic prostatic inflammation is a critical factor that exacerbates lower urinary tract symptoms (LUTS). The serum C‐reactive protein (CRP) level is one of the most common markers with which to assess the degree of inflammation, and it has been reported to be related to the severity of LUTS. However, it is not clear whether the CRP level is linked to the magnitude of prostatic inflammation. We evaluated the relationship between the serum CRP level and the magnitude of prostatic inflammation and assessed the influence of CRP on the severity of LUTS. Methods We evaluated the tissue specimens of 121 benign prostatic hyperplasia (BPH) patients who underwent surgery for BPH and preoperative measurement of the serum CRP level. We quantified the magnitude of prostatic inflammation histologically by determining the number of high endothelial venule (HEV)‐like vessels and assessed the relationship between the serum CRP level and the HEV‐like vessels. We divided the patients into two groups based on the median serum CRP level and compared the clinical parameters of the two groups. Results The serum CRP level was correlated with the overactive bladder symptom score, whereas it was not correlated with the number of HEV‐like vessels. In filling cystometry and pressure‐flow study, the proportion of patients with detrusor overactivity in the higher‐CRP group was higher than that in the lower‐CRP group. Conclusions Our present study showed that the serum CRP level was significantly associated with storage dysfunction; in contrast, it was not a surrogate marker of prostatic inflammation.

show abstract

Appearance of High Endothelial Venule‐Like Vessels in Benign Prostatic Hyperplasia is Associated With Lower Urinary tract Symptoms

Inamura

Shinagawa²,

Hoshino

et al. 2017

The Prostate

View full text Add to dashboard Cite

show abstract

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

Cited by 42 publications

References 31 publications

Is There a Relationship between Lower Urinary Tract Symptoms and C-reactive Protein Levels in Men? A Cross-Sectional Study

Is There a Relationship between Lower Urinary Tract Symptoms and C-reactive Protein Levels in Men? A Cross-Sectional Study

Serum C‐reactive protein level is not associated with prostatic inflammation but with overactive detrusor in patients with benign prostatic hyperplasia

Appearance of High Endothelial Venule‐Like Vessels in Benign Prostatic Hyperplasia is Associated With Lower Urinary tract Symptoms

Contact Info

Product

Resources

About