Increased secretion of tumor necrosis factor α and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction

Gosset, Philippe; Tsicopoulos, Anne; Wallaert, B.; Vannimenus, Corinne; Joseph, M.; Tonnel, André‐Bernard; Càpron, André

doi:10.1016/0091-6749(91)90149-i

Cited by 258 publications

(135 citation statements)

References 32 publications

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“…Indeed, TNF-a levels are increased in several inflammatory diseases including asthma and chronic obstructive pulmonary diseases [7,11]. It has also previously been demonstrated that Sephadex particles increase TNF-a messenger ribonucleic acid (mRNA) and protein expression in lung epithelial cells, lung granulomas and BAL cells [12].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation

Belvisi¹,

Haddad²,

Battram³

et al. 2000

Eur Respir J

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Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), is a seleno-organic compound which protects tissues against oxidative stress. Furthermore, recent data has suggested that this compound possesses a range of anti-inflammatory properties.In this study the authors have investigated the effects of ebselen on Sephadexinduced lung oedema and bronchoalveolar lavage (BAL) tumour necrosis factor (TNF)-a and endothelin(ET)-1 levels in rats.Sephadex administration induced lung oedema which was accompanied by an increase in BAL TNF-a and ET-1 levels. Ebselen administration (1±30 mg . kg -1 , i.p. at 0, 4 and 12 h post Sephadex) significantly inhibited lung oedema (dose that produced 50% of the maximum inhibition of lung oedema 4.6 mg . kg -1 ) and BAL TNF-a levels in a dose-related manner with no effect on ET-1 levels.These data suggest that ebselen may be a useful therapy in lung pathologies in which bronchiolar inflammation is a feature. The Sephadex model of lung oedema in the rat is a model of acute alveolitis and bronchiolitis leading to inflammatory cell infiltration and interstitial oedema which appears to parallel many of the pathophysiological features associated with human interstitial lung diseases [1]. This model has been used previously to demonstrate the anti-inflammatory properties of compounds such as glucocorticosteroids based upon the modulation of lung oedema [2].Ebselen (2-phenyl-1,2-benzisoselenazol-3 (2H)-one) is a selenium-containing organic compound which has been found to protect tissue against oxidative attack by mimicking glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase [3]. In addition, ebselen possesses a range of anti-inflammatory activities including inhibition of the enzymes 5-lipoxygenase, inducible nitric oxide synthase, reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and inactivation of leukotriene B 4 to its biologically inactive 6-trans isomer [4]. In view of its interesting anti-inflammatory profile in a variety of animal models of inflammation [1,5], the authors investigated its effects in the Sephadex model of lung oedema. In addition, the effect of ebselen was examined on tumour necrosis factor (TNF)-a and endothelin(ET)-1 levels in the bronchoalveolar lavage (BAL) fluid from Sephadex-treated rats since these cytokines have been postulated to have a role in inflammatory lung disease [6±9]. Materials and methods AnimalsMale, Sprague-Dawley rats (350 g) were purchased from Harlan-Olac (Bicester, Oxfordshire, UK) and housed for 1 week before initiating experiments. Food and water were supplied ad libitum. Experiments were performed in accordance with the UK Home Office guidelines for animal welfare based on the Animals (Scientific Procedures) Act 1986 [10] and following approval from the Aventis Pharma Animal Care and Use Committee. MethodsRats were dosed intratracheally (i.t.) with vehicle (saline) or Sephadex beads (5 mg . kg -1 ) in a dose volume of 1 mL . kg -1 under halothane anaesthesia (4% in oxygen for 3 min). Ebselen (1...

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation

Belvisi¹,

Haddad²,

Battram³

et al. 2000

Eur Respir J

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“…In individuals with AEDS and allergic asthma, significantly higher IL-6 levels have been found in the serum than in a control group (21,22). In vivo and in vitro, IL-6 acts as a differentiation factor for B cells and as an activation factor for T cells.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of Gene Induction After FcεRI Ligation of Atopic Monocytes Identified by Suppression Subtractive Hybridization

Bubnoff

Matz

Cazenave

et al. 2002

The Journal of Immunology

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The high-affinity receptor for IgE, FcεRI, on APCs plays an important role in the initiation and chronicity of inflammatory atopic diseases. To understand the molecular regulation of FcεRI-mediated processes, differentially expressed genes are of great interest to be identified. Suppression subtractive cDNA hybridization has been used to identify genes induced after FcεRI stimulation on atopic monocytes. Overexpression of the identified genes was determined by semiquantitative RT-PCR analysis of transcripts from the tester (stimulated) and driver (unstimulated) monocytes. Results were confirmed and kinetics of the transcripts established using blood cells from additional atopics at 4 and 24 h of FcεRI induction. The following sequences were identified: monocyte chemoattractant protein 1, macrophage-inflammatory protein 1β, IL-6, βA subunit of inhibin/activin, IFN-stimulated gene of 54 kDa, IL-1R antagonist, and kynurenine 3-monooxygenase. Chemokines are highly expressed during the early and late phase after FcεRI cross-linking, whereas proinflammatory and differentiation stimuli rapidly decline after an initial overexpression. Kynurenine 3-monooxygenase, an enzyme involved in the degradation of the amino acid tryptophan, is significantly up-regulated during the late phase after 24 h of FcεRI induction. These results demonstrate that the analysis of the profile of gene induction following activation of FcεRI on atopic monocytes may reveal how these cells might participate in the regulation of atopic disorders.

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“…26,27) IL-6 is also produced from mast cells in released allergic inflammatory diseases such as rheumatoid arthritis (RA) and asthma. 28,29) Moreover, its local accumulation is associated with a PCA reaction. 30) IL-8 acts on such inflammatory effector cells as neutrophils, T lymphocytes, B lymphocytes, and eosinophils.…”

Section: Discussionmentioning

confidence: 99%

Lithospermi radixExtract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells

Kim¹,

Kim²,

Moon³

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Increased secretion of tumor necrosis factor α and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction

Cited by 258 publications

References 32 publications

Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation

Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation

Kinetics of Gene Induction After FcεRI Ligation of Atopic Monocytes Identified by Suppression Subtractive Hybridization

Lithospermi radixExtract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells

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