Increased risks between Interleukin-10 gene polymorphisms and haplotype and head and neck cancer: a meta-analysis

Abstract

Molecular epidemiological research suggests that interleukin-10 (IL-10) polymorphisms may be associated with an increased risk of head and neck cancer (HNC), but results remain controversial. To derive a more precise evaluation, we performed a meta-analysis focused on genetic polymorphisms of IL-10. PubMed, Embase, CNKI and Wanfang databases were searched for studies that examined the relationship between IL-10 polymorphisms or haplotypes and HNC risk. The odds ratio (OR) and 95% confidence interval (CI) were applied to assess the relationship strength. Publication bias, sensitivity and cumulative analyses were conducted to measure the robustness of our findings. Overall, nine related studies involving 2,258 patients and 2,887 control samples were analyzed. Significant associations between the IL-10-1082A > G polymorphism and HNC risk were observed (G vs. A: OR = 1.56, 95% CI = 1.27–1.92, P < 0.01, I2 = 69.4%; AG vs. AA: OR = 1.64, 95% CI = 1.32–2.05, P < 0.01, I2 = 55.6%; GG vs. AA: OR = 2.24, 95% CI = 1.69–2.97, P < 0.01, I2 = 38.5%; AG + GG vs. AA: OR = 1.70, 95% CI = 1.36−2.14, P = 0.02, I2 = 61.8%; GG vs. AA + AG: OR = 1.89, 95% CI = 1.23−2.90, P = 0.01, I2 = 46.3%) in the total population, as well as in subgroup analysis. Moreover, increased HNC risks were also associated with the IL-10 −819T > C polymorphism and the GCC haplotype. In conclusion, our meta-analyses suggest that IL-10 polymorphisms, specifically the −1082A > G polymorphism, may be associated with increased risk of HNC development.

Significant association between Let-7-KRAS rs712 G > T polymorphism and cancer risk in the Chinese population: a meta-analysis

“…Quality assessment of included studies was evaluated with modified Newcastle-Ottawa scale (NOS) by two authors, and the scores ranged from 0 points (worst) to 9 points (best) (Table 3) [35]. …”

Associations between dopamine D2 receptor gene polymorphisms and schizophrenia risk: a PRISMA compliant meta-analysis

“…Two authors (HH and HW) independently performed quality assessment using quality scoring criteria20 based on criteria previously applied in observational studies for addressing genetic epidemiological issues, with the scores ranging from 0 points (worst) to 9 points (best) (Table S1). A study was classified as being of low quality when it scored <6 points.…”

Inflammatory breast cancer: High incidence of GCC haplotypes (−1082A/G, −819T/C, and −592A/C) in the interleukin-10 gene promoter correlates with over-expression of interleukin-10 in patients’ carcinoma tissues

“…30 IL-10 −819C/T SNP found to be associated with the risk of lung cancer, 31 urothelial bladder cancer, 32 and head and neck cancer. 23 IL-10 −592A/C was found to be associated with the risk of lung cancer, 31 non-Hodgkin's lymphoma, 33 and cervical cancer. 34 In breast cancer, studies conducted by Smith et al, 35 Kong et al, 36 and AlSuhaibani et al, 37 and meta-analysis 38 showed no association between IL-10 −1082A/G polymorphism and breast cancer incidence.…”

“…22 Polymorphisms in the IL-10 gene are found to play important role in cancer progression. Studies showed that IL-10 −1082A/G SNP was associated with poor prognosis of head and neck cancer, 23 oral cancer, 24 oral squamous cell, 25 cutaneous malignant melanoma, 26 prostate cancer, 27,28 digestive cancer, 29 and cervical carcinoma. 30 IL-10 −819C/T SNP found to be associated with the risk of lung cancer, 31 urothelial bladder cancer, 32 and head and neck cancer.…”